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At the final battle between Macbeth and Macdoth when Macbeth learns Macdoth was a C-section baby he gives up and just gives up and says "enough".

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Lady Macbeth on several occasions freaks out and starts crying. toward the end of the play she goes crazy and this leads her to commit suicide later on before the battle.

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A couple times throughout the play Macbeth talks about how he can't sleep at night, and even Lady Macbeth couldn't sleep so you see the mental toll on both of them.

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Before Duncan's murder Macbeth was having second thoughts and had a hard time processing what he was about to do. After the murder he freaked out and was hearing voices.

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The psychoanalytical lens works best for Macbeth because you see the internal struggle he is going through with what he has done.