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March 3, 1820
Congress passed a bill granting Missouri statehood as a slave state under the condition that slavery was to be forever prohibited in the rest of the Louisiana Purchase north of the 36th parallel, which runs approximately along the southern border of Missouri.

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January 1, 1831
The Liberator, weekly newspaper of abolitionist crusader William Lloyd Garrison for 35 years was the most influential antislavery periodical in the pre-Civil War period of U.S. history.

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Aug 21- 23, 1831
Nat Turner's Rebellion was a rebellion of black slaves that took place in Southampton County, Virginia, led by Nat Turner. The rebels killed between 55 and 65 people, at least 51 of whom were white

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Apr 25, 1846
The Mexican–American War, also known in the United States as the Mexican War and in Mexico as the Intervención Estadounidense en México, was an armed conflict between the United States and Mexico

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January 29, 1850
An attempt to seek a compromise and avert a crisis between North and South. As part of the Compromise of 1850, the Fugitive Slave Act was amended and the slave trade in Washington, D.C., was abolished.

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March 20, 1852
An abolitionist novel, it achieved wide popularity, particularly among white readers in the North, by vividly dramatizing the experience of slavery.

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March 20, 1854
Republican Party, Grand Old Party (GOP), in the United States, one of the two major political parties, the other being the Democratic Party. During the 19th century the Republican Party stood against the extension of slavery to the country’s new territories and, for slavery’s complete abolition.

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May 30, 1854
During the antebellum period of U.S. history, critical national policy change concerning the expansion of slavery into the territories, affirming the concept of popular sovereignty over congressional orders.

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May 22, 1856
Representative Preston Brooks, a pro-slavery Democrat from South Carolina, used a walking cane to attack Senator Charles Sumner, an abolitionist republican from Massachusetts, in retaliation for a speech given by Sumner two days earlier in which he fiercely criticized slaveholders, including a relative of Brooks.

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March 6, 1857
Ib the Dred Scott decision the U.S. Supreme Court ruled (7–2) that a slave (Dred Scott) who had resided in a free state and territory (where slavery was prohibited) was not thereby entitled to his freedom

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October 16-18, 1859
Abolitionist John Brown leads a small group on a raid against a federal armory in Harpers Ferry, Virginia (now West Virginia), in an attempt to start an armed revolt of enslaved people and destroy the institution of slavery

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November 6, 1860
voters in the United States went to the polls in an election that ended with Abraham Lincoln as President

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December 20, 1860
South Carolina became the first slave state in the South to declare that it had seceded from the United States. James Buchanan, the United States president, declared the ordinance illegal but did not act to stop it.