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- Antiplatelet agent
- Selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, thereby inhibiting platelet aggregation

Image from: https://prospecte.ro/en/pacient/plavix-medicine-leaflet-75mg-x30-tablets-sanofi-w61520013

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Percutaneous coronary intervention (PCI) or angioplasty with stent

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Indicated for prevention of stenosis of coronary stents or for secondary prevention of myocardial infarction (MI), ischemic stroke, or other vascular events.

Image from: http://www.vhlab.umn.edu/atlas/device-tutorial/stents/index.shtml

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- Obtain CBC periodically
- Assess bleeding risk
- Educate patient about reporting s/s of bleeding (including  GI bleeding)
- PO daily, regardless of meals
- Interactions between drugs that promote bleeding and PPI

Image from: https://www.istockphoto.com/es/search/2/image?phrase=nurse&irgwc=1&cid=IS&utm_medium=affiliate_SP&utm_source=FreeImages&clickid=VXsSjuVpGxyIUeyyXrx9pzZKUkD0akwQE02SVU0&utm_term=site_search_bar&utm_campaign=&utm_content=270498&irpid=246195

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- Oral administration daily, with or without food
- Rapid absorption through the GI tract
- Extensively protein bound
- Metabolized in the liver
- Effects are irreversible to the platelets affected

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- Well tolerated
- Bleeding (i.e. cuts, nosebleeds)
- Bruising
- Upset stomach
- Fatigue
- Risk of thrombotic thrombocytopenia purpura (TTP)

Image from: http://globalindiannurses.org/thrombotic-thrombocytopenic-purpura/

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Lexicomp. (2022, May 17). Clopidogrel. Retrieved from https://online-lexi-com.proxygw.wrlc.org/lco/action/doc/retrieve/docid/patch_f/6645?cesid=2scTwHM5yrZ&searchUrl=%2Flco%2Faction%2Fsearch%3Fq%3Dclopidogrel%26t%3Dname%26acs%3Dtrue%26acq%3DClopidogre

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A patient began taking clopidogrel (Plavix) after experiencing a transient ischemic attack. What is the desired therapeutic effect of this drug?

A. Anti-inflammatory and antipyretic effects
B. To reduce the risk of stroke from a blood clot
C. Analgesic as well as clot-dissolving effects
D. To stop clots from becoming emboli