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Zmapp is designed to target the surface protein of the Ebola virus.

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REGN3470 targets Glycan Cap
REGN3471 targets Receptor Binding Site
REGN3479 targets Fusion Loop

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Mab114 recognise an epitope spanning & binds to the region of both the glycan cap and the GP1 core. mAb114 binds to the GP1 head on an epitope at the physical intersection of the glycoprotein subunits.

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ZMapp inhibits Ebola virus replication by binding to RNA in sequence-specific manner to VP24 gene.

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ZMapp inhibits Ebola virus replication by binding to RNA in sequence-specific manner to VP24 gene.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621129/