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Variola Major also known as (smallpox) is the infection of the oropharyngeal(mouth) or respiratory(trachea and lung)mucosa.

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Variola Major is transmitted by human-to-human transmission such as inhalation of a large virus containing airborne droplets of saliva from an infected person. It can be spread through the air in an enclosed setting. Smallpox is contagious but it is not spread as easily as other viruses such as influenza or measles. It takes really close face to face contact or living in a home with someone that has it to catch this virus.

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Variola Major has many symptoms some major and some minor. Symptoms often begin 12-14 days after infection. The symptoms include fever, muscle aches, headache, severe fatigue, severe back pain, and vomiting. The minor symptoms include high fever, fatigue, severe back pain, and sometimes abdominal pain. The major symptoms are producing a large rash with bumps full of clear liquid, which will later fill with pus and will develop a crust that dries and falls off.

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There are ways to prevent catching the Variola Major disease. Vaccinia Virus Vaccine also known as the smallpox vaccine is the number one way of preventing the pathogen. The vaccine is made from the vaccinia virus which is similar to smallpox but not as severe. The vaccine has to be given at least 3 days before exposure to prevent the disease. It may decrease symptoms if given the first week of exposure.

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Pregnant women are at high risk for catching Variola Major. Both vaccinated and unvaccinated women during pregnancy who contract variola virus, the causative agent of smallpox, suffer much higher mortality rates than nonpregnants. Which can lead to spontaneous abortion, premature termination, and early postnatal infant mortality.