# data[].attributes.body
Diversity is actually really present at the bottom of science's heart. Diversity inside science is found in DNA because DNA is different in every human being. Therefore, the root of diversity can be traced back to our genetics.

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When the male gamete combines with the female gamete

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This table proves us that the chances of a couple having a boy child, or a girl child is 50% vs 50%

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How can I represent that to know the chances of having green or brown eyes?

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How can I represent that to know the chances of having green or brown eyes?

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This Punnet Square shows the chances of you having brown or green eyes. It contains a 4:1 ration, meaning that you have 75% chance of having a brown eyes, and 25% chance of having green eyes.

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If my mom has brown eyes, but my dad has green eyes, what color would my eye be?

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If my mom has brown eyes, but my dad has green eyes, what color would my eye be?

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Brown is always dominant over green, so we can say that brown is dominant, and green is recessive.

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Genes are short pieces of DNA that carry specific genetic information.

Sources:

Dr. Giorgi and Ms. Barbelli

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Feminine people typically have two X chromosomes (XX), while male people typically have one X and one Y chromosome (XY). There are, however, several exceptions to this rule. Women inherit one X chromosome from their father and the other X chromosome from their mother when they are born. Men who are genetically male always receive their mother's X chromosome. Additionally, it is believed that their Y chromosomes develop from X chromosomes through a process of degeneration and gene loss.

Sources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921885/#:~:text=Classically%20Y%20chromosomes%20are%20thought,in%20an%20informative%20phylogenetic%20context.

https://www.genome.gov/about-genomics/fact-sheets/X-Chromosome-facts#:~:text=Typically%2C%20biologically%20female%20individuals%20have,X%20chromosome%20from%20their%20mother.

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Abstract

Classically Y chromosomes are thought to originate from X chromosomes through a process of degeneration and gene loss. Now, the availability of 12 Drosophila genomes provides the opportunity to study the origin and evolution of Y chromosomes in an informative phylogenetic context. Surprisingly, the majority of Drosophila Y-linked genes are recent acquisitions from autosomes, and Y chromosome gene gains are more frequent than gene losses. Moreover, the D. pseudoobscura Y chromosome lacks homology with the Y of most Drosophila species. Thus the Drosophila Y has a different evolutionary history from canonical Y chromosomes (such as the mammalian Y), and it also might have a different origin.

Sex chromosome origins

Sex chromosome evolution provides a particularly coherent and satisfying blend of empirical data and theory. According to canonical theory, X and Y chromosomes (for the sake of simplicity we called the "W" chromosome of birds and butterflies as "Y" [ 1]) originate from an autosomal pair via a three-step process that begins with the acquisition of one or more strong sex-determining genes by one autosome, giving rise to nascent X and Y chromosomes. Natural selection then favors the suppression of recombination between the two chromosomes. The lack of recombination, together with the joint effects of mutation, natural selection, and genetic drift, then leads to progressive degeneration and loss of Y chromosome genes, until only the sex-determining gene(s) and a few relic genes survive [ 1- 5]. As the X chromosome become progressively haploid in males ("hemizygous"), natural selection favors increased transcription of X-linked genes in males, through several dosage compensation mechanisms [ 1, 2]. In the later stages, the Y usually becomes heterochromatic, accumulating large amounts of repetitive DNA. It also frequently acquires male-specific genes from the autosomes [ 6, 7] (or female-specific genes in the case of the W chromosome, where ZW is female and ZZ is male). Empirical data in a variety of organisms including plants and birds support this scenario, the evidence being particularly clear in mammals. The most compelling evidence is provided by the observation that among the 27 different proteins encoded by the human Y, 18 have an ancestral, close counter-part on the X chromosome [ 6]. This generality, coupled with the beautiful fit between theory and data, has led to the widespread assumption that all Y chromosomes arise through this path (or by the related neo-Y pathway; Box 1), invariably being homologous to X chromosomes.

Box 1Neo-Y chromosomes

X0/XX systems are believed to arise from an XY system, by degeneration and loss of the Y [ 1]. A Y chromosome can be "regenerated" in these species when an autosome fuses to the X chromosome, and the new arrangement is fixed within a population ( Fig. 1 , panel B). During male meiosis the free homolog of the fused autosome continues to pair with the newly added portion of the X (termed "neo-X") and move to the opposite pole of the cell, behaving as a Y chromosome (hence its name, "neo-Y"). Neo-Y chromosomes are male-restricted and the same evolutionary factors that cause the degeneration of Y chromosomes are expected to act on them. Empirical data confirm that they accumulate repetitive DNA and that their genes degenerate. Indeed Drosophila neo-Y systems are popular models to study Y-chromosome degeneration [ 12, 48]. There are important differences between canonical Y and neo-Y evolution [ 38]; nonetheless, in both cases the Y originated through degeneration (of the X or the neo-X).

Fusions between the sex chromosomes (either the X or Y) and autosomes also occur in XY/XX species. D. pseudoobscura and its close relatives exemplify the former case: their X chromosomes stem from a fusion between the ancestral X and an autosome [ 1]. Following fixation of the X-autosome fusion the ancestral lineage must have passed through a "X/Y/neo-Y" stage, in which three chromosomes pair during male meiosis (the female meiosis is normal). Not surprisingly, such an event causes meiotic problems, and a similar system in another Drosophila species generates 1-3% of sex-chromosome aneuploidy [ 49]. This intermediate stage usually is short lived, and in a few million years only one Y chromosome remains; it is believed that the neo-Y is lost or fused to the ancestral Y [ 1]. However, the outcome was surprisingly different in the D. pseudoobscura lineage: the ancestral Y was incorporated into an autosome and was replaced by a new Y chromosome, possibly derived from the neo-Y [ 8].

Prior to 2000, an extensive identification of Y-linked genes had been done only in humans [ 7]. The genome sequencing of D. melanogaster in 2000, followed by D. pseudoobscura (2003) and now by 10 additional Drosophila genomes (2007) uncovered several unexpected phenomena, including the lack of X-Y shared genes, a wholesale replacement of the Y chromosome in the D. pseudoobscura lineage, and the preponderance of gene gains (in comparison to gene losses) in the 12 sequenced Drosophila species. Here we review these data and explore their consequences in the broader context of Diptera sex-chromosome evolution. We concentrate on single copy genes on the Drosophila Y, with an emphasis on results [ 8, 9] appearing since the last review on this subject [ 10]. Readers interested on the role of repetitive DNA in the evolution of the Drosophila Y chromosome and on evolutionary models of Y-degeneration should consult references [ 4, 11- 13].

D. melanogaster Y chromosome: a lack of X-Y homology

The D. melanogaster Y chromosome is comprised mainly of repetitive DNA, and is heterochromatic. It does not determine sex; instead, in Drosophila sex determination is basically accomplished by a count of the number of X chromosomes [ 14, 15]. However, males devoid of Y chromosomes ("X0 males") are sterile [ 16], and formal genetic studies identified 6 genes that are essential for male fertility in the D. melanogaster Y [ 17- 20]. Now, genome sequencing and the development of proper bioinformatics methods allows a thorough molecular identification of the Y chromosome gene content [ 21- 23]. Despite its large size (~40 Mbp), it contains few single-copy protein-coding genes: 12 are currently known, and indirect evidence suggests an upper bound of ~20 genes [ 21- 24]. These genes are unusually large, due to Mbp-sized introns composed of repetitive DNA [ 25]. D. melanogaster Y-linked genes have two additional important features: many (and probably all) have male-related functions ( e.g., encoding sperm flagella motor proteins), and all arose by duplication from autosomal genes [ 9, 21- 24]. The initial step of their origin must have been a gene duplication that created a mutant Y carrying a copy of an autosomal gene. Then in some cases the mutant Y became fixed in the population, either by genetic drift or because it conferred a selective advantage to males that carried it. Given their redundancy, the autosomal copy could have pseudogenized and disappeared, the new Y-linked copy could have disappeared, or the two copies could have retained functionality, possibly by diverging to perform different functions [ 26]. Different Y-linked genes illustrate each of these steps. The flagrante delicto Y gene ( FDY), which is present only in D. melanogaster (estimated age: ~2 Myr) is the youngest gene we identified. It arose from a genomic duplication of the autosomal gene CG11844 gene to the Y, and the flanking sequences remain clearly recognizable [ 27]. The autosomal and the Y-linked copies are still present and functional. By contrast, the WD40 Y gene ( WDY) and the male fertility factor kl5 gene ( kl-5) arrived to the Y chromosome ~50 Myr ago and in these cases the autosomal copies were lost [ 9, 23]. However, the autosomal copy does not appear to be lost in all old transpositions: the Protein Phosphatase 1 Regulatory Subunit Y gene ( Ppr-Y), for example, arrived on the Y chromosome more than 63 Myr ago, and this gene as well as the putative autosomal parent gene CG13125 have been retained [ 9, 22]. The D. melanogaster Y chromosome does not share any single-copy genes with the X. This unusual feature is made clear when the D. melanogaster and human Y chromosomes are compared ( Fig 1 ): the "X-ancestral" genes, which comprise the majority of Y-linked genes in mammals and are the hallmark of the X-Y shared ancestry, are absent in D. melanogaster Y. As Drosophila Y-linked genes came from the autosomes, one might expect some inter-specific variation, but at what time scale? Years ago we cautiously wrote that "the genic content of the Y chromosome would be fluid and may differ among (...) species [of the Drosophilidae family]" [ 22]. As described in the next section, when the 12 Drosophila genomes became available it was found that Y chromosome gene content differs even among species of the same group [ 8, 9].

The 12 Drosophila Y chromosomes: a prominent role of gene gains

Before examining the results of Koerich et al. [ 9], it is worth mentioning a caveat. Ideally one should have the complete gene set of the Y chromosomes in the 12 species before starting the comparative analysis, as has been done (at least approximately) with the euchromatic portion of the other chromosomes. However, given the notorious difficulties in sequencing and assembling heterochromatic regions and the Y [ 27, 28], Koerich et al. [ 9] investigated Y-linkage in the Drosophila orthologs of the D. melanogaster Y-linked genes. The ensuing ascertainment bias should be corrected when estimating gene gain and loss rates [ 9]. The special case of two species ( D. pseudoobscura and the closely related D. persimilis) will be discussed in the next section, because the changes in their Y-chromosome gene content were caused by a wholesale replacement of the Y, rather than by individual gains and losses of genes [ 8].

In many cases the orthologs of the D. melanogaster Y-linked genes were autosomal in other species. This change in chromosomal location can be explained either by an autosome to Y transposition in the D. melanogaster lineage ( i.e., a gene gain in the Y) or by a Y to autosome transposition in the other lineage ( i.e., a gene loss in the Y). Additional data based on synteny, however, provided unambiguous answers ( Fig 2 ). Among the 12 known D. melanogaster Y-linked genes, 7 were acquired by the Y in the D. melanogaster lineage less than 63 Myr ago [ 9]. This pattern contrasts sharply with the rest of the genome, where ~95% of the genes remained on the same chromosome arm across the 12 species [ 29]. However, the absolute number of gene movements is similar in the Y and in the other chromosomes. So why is the Y-linked gene content so poorly conserved? The most likely explanation is that the other chromosomes had thousands of genes in the ancestor of the 12 sequenced species, whereas the Y chromosome had a very low number of genes (we know of five: male fertility factor kl2 ( kl-2), male fertility factor kl3 ( kl-3), Ppr-Y, Polycystine-Related-Y ( PRY) and Occludin-Related-Y ( ORY); Fig. 2 ). This condition, coupled with a small and similar number of gene movements in the Y and the other chromosomes, would produce the present pattern of low conservation of gene content in the Y chromosome and high conservation in the other chromosomes. This pattern dates back to mosquitoes, which diverged from Drosophila ~260 Myr ago: although there are clear homologies in other chromosomes between these Diptera [ 30, 31], all orthologs of D. melanogaster Y-linked genes are autosomal in mosquitoes. Thus, the gene content of the Drosophila Y is younger than the other chromosomes.

Comparisons between gene gains and losses also yield interesting clues about the evolution of the Drosophila Y: the rate of gene gain is ~11 times higher than the rate of gene loss ( P = 0.003; 95% confidence interval: 2.3-52.5; ref [ 9]). Thus, the Drosophila Y shows another unusual pattern (for a Y-chromosome): gene gains play a prominent role in its evolution, and at least in the last 63 Myr its gene content has indeed increased. This finding also suggests that the Drosophila Y is relatively young, because it is gaining genes and yet has few of them.

The D. pseudoobscura case: wholesale replacement of the Y chromosome

Given the phylogenetic proximity between D. melanogaster and D. pseudoobscura (they belong to the sister groups melanogaster and obscura) we expected their Y chromosomes to be very similar. Instead, they have nothing in common! The ancestral Drosophila Y chromosome became part of an autosome in the D. pseudoobscura lineage and was replaced by a new Y chromosome, possibly derived from a neo-Y [ 8]. This new Y chromosome is essential for male fertility [ 32], so it presumably acquired one or more fertility genes from other chromosomes, by the process outlined above for D. melanogaster (alternatively, some mechanical problem in meiosis might cause sterility in X0 males). We identified 15 genes and pseudogenes in the D. pseudoobscura Y chromosome, and none are shared with the D. melanogaster Y [ 8]. Hence, despite their functional and cytogenetic similarities (both are required for male fertility, pair with the X, and are heterochromatic), these Y chromosomes are not homologous. This unexpected finding has obvious implications for the origin and evolution of Y chromosomes, and raises the question of why it happened. A possible explanation follows. The incorporation of the ancestral Y into an autosome occurred only in species such as D. pseudoobscura and D. affinis which also have a known X-autosome fusion, whereas the more distantly related D. bifasciata and D. guanche (which do not have the X-autosome fusion) still carry the ancestral Y [ 8]. As detailed in Box 1, this association provides a clue: X-autosome fusions cause meiotic problems because three chromosomes (the ancestral Y, the X and the neo-Y) have to pair. Hence, the incorporation of the ancestral Y into an autosome may have been advantageous because it solved the meiotic problems caused by the X-autosome fusion.

For a long time, it was thought that the D. pseudoobscura Y chromosome was the ancestral Y, and that the neo-Y was lost or was incorporated into the ancestral Y [ 1]. Instead, the genomic data showed that the Y became part of an autosome. The data also suggest a possible origin for the current Y: it might be a degenerated neo-Y. The finding that 10 of the 15 known genes and pseudogenes have homologs on the neo-X (the autosome that became fused to the ancestral X) seems at first sight to confirm this hypothesis; but actually the evidence is at best weak, for two reasons. First, the 15 genes do not represent independent events because most of them are adjacent to each other in their original locations. They came from five different locations, and among these five, only two are homologous to the neo-X [ 8]. Hence the proper evidence in favor of a neo-Y origin of the D. pseudoobscura Y is not 10 out 15, but rather two out five. Second, and more importantly, if these 15 Y-linked genes are part of the neo-Y chromosome originated by the X-autosome fusion, at least some should be present in the Y chromosome of other species that share the same X-autosome fusion. However, in preliminary experiments done in two labs (we and Carlos Machado's), the presence of none of the 15 genes could be confirmed by PCR-amplification even in the closely related D. persimilis. This failure, coupled with the high nucleotide identity (typically above 97%) between these 15 Y-linked genes and their autosomal paralogs, strongly suggest that they are recent acquisitions that occurred after the X-autosome fusion. The bottom line is that the neo-Y hypothesis provides a simple explanation for the origin of the current Y, but the question remains unsolved. Identification of more Y-linked genes, as well as identification of the pairing regions between the X and Y in D. pseudoobscura may provide an answer. But the data in hand already show that Drosophila Y chromosomes can be very labile; indeed, chromosomes that appear to be identical ( e.g., those of D. melanogaster and D. pseudoobscura) can be non-homologous. These new results also hint that X-chromosome pairing and a determining role in male-fertility, characteristics that define a Drosophila Y chromosome, can evolve rapidly (the current D. pseudoobscura Y originated between 2 to 18 Myr ago; [ 8]) and provide little information about the origin of the chromosome itself.

How frequent is the phenomenon of wholesale replacement of the Y? Does it occur in every case of X-autosome fusion? Is it restricted to species with X-autosome fusion, as required by the "neo-Y origin" hypothesis? These three questions are amenable to direct experimental investigation, and already the results described in the previous section answered one of them. In particular, D. willistoni, which has undergone an independent X-autosome fusion, carries the ancestral Y chromosome [ 9]; therefore Y-autosome fusions do not necessarily follow X-autosome fusions. The remaining two questions are being addressed by an ongoing study of a large number Drosophila species. Preliminary data suggest that among the 310 tested species, 42 had their Y chromosomes replaced, owing to four independent events (the D. pseudoobscura lineage case, and three additional lineages). None of the three additional events (amounting to 34 species) has a X-autosome fusion, so the current Y of these species cannot be a degenerated neo-Y. Instead, they must have a different origin.

An alternative hypothesis for the origin of the Drosophila Y

Given the many similarities between the Drosophila Y and other Y chromosomes (X-Y pairing, low gene density, heterochromatic state), and the seemingly universal validity of sex-chromosome evolution theory, it is easy to understand why the Drosophila Y is generally thought to have originated through the same canonical path. However, researchers have repeatedly uncovered contradictory evidence while studying this chromosome in detail. The Drosophila Y lacks a sex-determining gene [ 16], which, according to the canonical model, should be present. Furthermore Brosseau [ 17] (see also [ 33]) commented that "the Y has no genetic regions homologous to most of the X (...). This view is diametrically opposed to the notion that the Y is a degenerate X." Finally, the recent genomic data [ 8, 9, 21- 23] reviewed in the previous sections also do not fit well with the canonical model. Each of these discrepancies can be accommodated by an ad hoc assumption: the lack of X-Y shared genes can be explained by the assumption that all signs of X-Y homology were erased. The lack of a male sex-determining gene can be explained by the assumption that the degeneration erased even this gene (or by the Drosophila Y being a neo-Y; but see below). The odd D. pseudoobscura data could be rationalized by the assumption that its current Y is a neo-Y (although this explanation ignores the unexpected wholesale replacement of the Y). To explain the prominent role of gene gains across the 12 species, one could assume that the Drosophila Y arose from the degeneration of the X chromosome, and hence only more recently have gene gains become important. Although these arguments cannot be completely excluded as a possibility, it might be time to consider alternative hypotheses that generate new experimental questions rather than ad hoc explanations. In fact, these discrepancies can be explained parsimoniously by the hypothesis that the Drosophila Y chromosome is not a degenerated X, but rather that it originated from the addition of an extra chromosome (that evolved the ability to pair with the X) to an XX/X0 sex-chromosome system ( Fig 1 , panel B; [ 10, 34]). Although this path might seem strange, it happened independently in two Homoptera species [ 35, 36], whose Y chromosomes originated from "B chromosomes" that evolved accurate pairing with the X-chromosome ( Box 2). B chromosomes are supernumerary dispensable chromosomes that are present in many species [ 1, 37].

Box 2Y chromosomes that originated from B chromosomes

Nokkala and co-workers showed that the Y chromosomes of two Homoptera species ( Rhinocola aceris and Cacopsylla peregrina) originated from "B chromosomes" [ 35, 36], supernumerary dispensable chromosomes that are present in many species [ 1, 37]. B chromosomes frequently have detrimental fitness effects, but, as in other cases of selfish genetic elements, their elimination from populations is prevented by meiotic drive. In some cases they evolve another mechanism that ensures their maintenance in populations: the ability to pair with X chromosomes in X0/XX species [ 37]. B chromosomes typically are heterochromatic and occur in variable numbers, both within and among populations; in the same population, individuals might carry 0, 1, 2, 3 or more copies. This characteristic provides the strongest evidence that the R. aceris Y originated from a B chromosome: in one population males and females carry a variable number of heterochromatic chromosomes which pair imperfectly with the X in males (making it clear that they are typical B chromosomes), whereas in other populations, a similar chromosome is present only in males, in a single copy, and nearly perfectly pairs with the X (like a bona fide Y chromosome). The foreknowledge that the basic sex chromosome system is X0/XX in the family Psylloidea [ 50], together with the maintenance of the number of autosomes in R. aceris, ruled out the possibility of a neo-Y origin. The lack of chiasmata between the X and Y of the two species (which are present in other Psylloidea species with neo-Y) provided additional evidence that their Y chromosomes originated from B chromosomes [ 35, 36].

As B chromosomes are rare, (although not absent) in Drosophila [ 51], perhaps a more likely source of a non-canonical Y chromosome is the small "dot" chromosome ( D. melanogaster chromosome 4; ref [ 34]). Indeed, trisomy for the dot chromosome is well tolerated [ 52], and it pairs with the X [ 53, 54]. Of course the suggestion of a non-canonical origin of the Drosophila Y does not imply that the canonical evolutionary mechanism could not operate in Drosophila: neo-Y chromosomes are known to degenerate in these species too ( e.g., [ 12, 48]). Therefore, the important question is whether or not the canonical model provides the most likely explanation, given the available evidence.

How common are these non-canonical Y chromosomes? It is common practice to term as Y any chromosome which pairs with the X and is present only in males; moreover, it is implicitly assumed to be a degenerated X, even if it does not play a role in sex-determination ( e.g., Drosophila). Thus, almost by definition non-canonical Y chromosomes will be overlooked. The unconventional origin of the Y chromosome of the Homoptera Rhinocola aceris was identified owing to the combination of incomplete fixation and high confidence of the ancestral state [ 35], which most likely reflects the fortuitous observation of a recent event. After the R. aceris study, a careful investigation of Cacopsylla peregrina revealed the same phenomenon [ 36]. It is likely that additional cases will be found, as researchers become aware of the possibility of non-canonical origin of Y-chromosomes, and tsetse flies, whose Y-chromosome has clear similarities with B chromosomes, may be an example ( Box 3). As the XX/X0 sex-chromosome system is widespread among insects, and is almost certainly the ancestral system in several orders [ 38], there might be many additional cases of Y chromosomes arising from B chromosomes. Furthermore, although it is easier to envisage the origin of non-canonical Y chromosomes in species with X0/XX sex-chromosomes, B chromosomes are also able to pair with the sex-chromosomes in XY/XX species [ 39].

Box 3The Y chromosome of tsetse flies

Tsetse flies (genus Glossina) are considered to have XY/XX sex-chromosome system, yet their Y chromosome is not involved in sex-determination and shows irregular segregation with the X [ 55]. Indeed, aneuploidy is common in natural populations ( e.g., X0, XY and XYY males co-exist [ 55]).

Furthermore, the Y seems to cause meiotic-drive in XXY females, as they produce twice as many XY as X eggs (Table 14.1 in [ 56]). Variable numbers and meiotic-drive are hallmarks of B chromosomes [ 1, 37], and if not for the sterility of X0 males [ 56], the Glossina Y would perfectly fit the definition of a B chromosome. Indeed Glossina is known to have B chromosomes [ 57], and the close similarity between their B and Y chromosomes in meiotic behavior and C-band pattern led Amos and Dover [ 58] to propose that their B chromosomes originated from the Y (but note that the opposite relationship - Y originated from B - additionally explains the irregular X-Y segregation). The Glossina genome currently is being sequenced. The genomic data, together with studies aimed at uncovering the ancestral state of sex-chromosomes in related families, might show whether or not the Glossina Y chromosome actually is a specialized B-chromosome that acquired male-fertility genes.

Will direct testing of the "non-canonical origin" hypothesis be possible in Drosophila? The Homoptera examples described above might provide some guidance. These cases were uncovered using cytogenetics (optical microscopy of chromosomes), and analogous work in the Drosophilidae sister families ( e.g., Ephydridae) is badly needed ( Box 4). Interestingly, the only Ephydridae species investigated so far has X0/XX sex-chromosomes [ 40]. As seen in R. aceris, uncovering recent events is critical as the mechanisms of Y origination have not yet been blurred by additional chromosomal changes. This forms part of the rationale for studying Y-linked gene content in ~300 Drosophila species; confirmation of the suspected cases of non-canonical Y origin in several Drosophila lineages would support a similar origin for the ancestral Drosophila Y. Finally, as the cost of genome sequencing continues to fall, it is certain that many Diptera genome sequences will become available during the next decade, shedding light on the origin and evolution of their sex chromosomes. For example, species in which the Y chromosome originated from a neo-Y should have a large block of additional genes (derived from the fused autosome) on the X chromosome, when compared to proper outgroups, even if the fusion is ancient. Some glimpses of this approach are already possible.

Box 4Cytogenetics and the origin of the Drosophila Y

Chromosome studies have provided important evidence for the origin of Y chromosomes in many species, and they are especially effective when the ancestral state, i.e. before the origin of the Y, is known [ 1, 35, 36]. The majority of Drosophila species have an XY/XX sex-chromosome system [ 59], so we must infer the ancestral state by looking outside the genus. The best outgroups for this purpose are the Steganinae subfamily (which belongs to the same Drosophilidae family) and sister families such as Ephydridae and Curtonotidae. Little is known about their chromosomes, and the limited data from more distant Acalyptrata families are contradictory, with one study suggesting that the Drosophilidae karyotype is highly derived [ 60], and another suggesting that it is ancestral [ 61]. An investigation of the karyotype of outgroups such as Ephydridae is clearly needed. This investigation should at least eliminate one mechanism from the list of possible origins of the Drosophila Y (X-degeneration, neo-Y, and non-canonical). For example, a X0/XX ancestral state would rule out the X-degeneration hypothesis. Neo-Y formation by X-autosome fusions can be detected by the reduction in the number of autosomes and (in many cases) by the transformation of a single-armed into a two-armed X [ 1]. The application of these ideas to the study of the origin of the Drosophila Y is hampered by the lack of data from the outgroups. The proposed cytogenetic approach also has some caveats. Neo-Y detection is straightforward in evolutionarily recent events with known ancestral state [ 1, 50, 62], but the Drosophila Y originated more than 63 Myr ago [ 9]; pending on the rate of chromosomal evolution, further changes that alter chromosome number and structure (such as chromosome fusions, fissions, and inversions) might have blurred the signs of the origin of the Y. Another limitation is that Y chromosomes that are non-homologous ( e.g., D. melanogaster and D. pseudoobscura; ref [ 8]) can look nearly identical when using simple cytogenetics methods ( e.g., orcein staining). However, the use of more elaborate cytogenetic methods, such as fluorescence in-situ hybridization (FISH) and chromosome painting ( e.g., [ 63]), can alleviate these concerns.

Mosquito ( Anopheles and Aedes) and Drosophila X chromosomes are homologous [ 30, 31]; therefore the genesis of the X (as well as presumably of a canonical Y) occurred more than 260 Myr ago, and X chromosome identity is conserved across very distant Diptera families. This ancestral X is the sole major contributor to the Drosophila X [ 30, 31], with no evidence of X-autosome fusions, which strongly suggests that the ancestral Drosophila Y is not a neo-Y. By contrast, half of the Aedes X chromosome is homologous to the Drosophila and Anopheles X, but the other half is homologous to a single autosome in each of these species [ 30], presumably due to a X-autosome fusion in the Aedes lineage. However, the Aedes Y is not a neo-Y: it is nearly identical to the X (except for the presence of the male-determining gene [ 41]), so additional changes happened. In contrast with mosquitoes, the X-chromosomes of the much more closely related families Tephritidae ( Ceratitis capitata) and Muscidae ( Musca domestica) are not homologous to the Drosophila X: they are completely heterochromatic, carry very few genes, and the genes orthologous to Drosophila X-linked genes that have been mapped are autosomal in these species [ 42, 43]. Thus, in some Diptera families the X chromosome likely was replaced; such a possibility creates an interesting problem with the pre-existing dosage compensation mechanism. Namely, the former X chromosome (now an autosome) is present in equal dose in males and females in these Diptera families and hence its hyper-transcription in males should had been turned off [ 44]. Besides Muscidae and Tephritidae, this prediction may be tested in Aedes, which seems to have evolved to a system with very little differentiation between the X and the Y [ 41].

Concluding remarks

What is a Y chromosome? A good definition is that it is a chromosome that regularly segregates from the X chromosomes, irrespective of its origin. Many Y chromosomes will be degenerated Xs or neo-Ys, and a currently unknown number (particularly among insects) will be traced to a non-canonical origin. The canonical theory of sex-chromosome evolution, with its emphasis on X-Y homology, slow degeneration and gene loss, provides an incomplete conceptual framework to study the Drosophila Y chromosome, in which there is no sign of X-Y homology, several cases of wholesale replacement appear to have occurred, and gene gains play a prominent role. By considering the possibility of a non-canonical origin, the focus shifts to questions such as the origin of the Drosophila Y, its evolutionary lability, the sex-chromosomes of Ephydridae and other Diptera families, and to the close relationship between Y and B chromosomes in some species. Throughout this review we have emphasized that these questions are amenable to experimental investigation, and therefore will be answered eventually. As the Glossina case suggests, such a shift in focus might illuminate Y chromosome evolution far beyond Drosophila.

On the experimental side, we cannot emphasize enough the importance of an exhaustive identification of Y-linked genes. This is the main obstacle to the study of the Y chromosome because its richness of repetitive DNA precludes sequence assembly into large and easily studied scaffolds. Instead short Y-linked scaffolds (usually between 1 kb and 100 kb) must be individually identified among thousands of unmapped scaffolds that came from other heterochromatic regions, using computational methods followed by experimental verification of Y-linkage [ 8, 21- 23]. The experimental verification is necessary due to the rather high rate of false-positives and false-negatives of the current computational methods; this step is labor intensive (when applied to hundreds of scaffolds), and in practice is done only in the scaffolds that seem to encode genes [ 8, 21- 23]. Two recent developments will make this individual experimental verification unnecessary, and hence are likely to have a deep impact on the knowledge of Y chromosomes. We developed a method based on short-read sequences that allows massive identification of Y-linked sequences [ 45]. This method is suited for genomes that have already been sequenced using male-female mixed libraries ( e.g., [ 46]). However, as proposed by Krzywinski et al. [ 47], the simple separation of male and female libraries before sequencing provides the most straightforward and powerful method to identify Y-linked sequences, at nearly zero additional cost. Currently several Anopheles genomes and the hemipteran Rhodnius prolixus are being sequenced in this way. We hope that this will become standard practice for future genome projects.

Acknowledgments

We thank B. Lemos, S. Nokkala, J. Lucchesi, Y. Tao, R. Arguello, and two anonymous reviewers for many valuable comments in the manuscript. This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq, Coordenação de Aperfeiçoamento do Pessoal de Ensino Superior-CAPES, FAPERJ, FIC-NIH grant TW007604-02 (A.B.C.) and NIH grant GM64590 (A.G.C. and A.B.C.).

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27. Carvalho AB, Clark AG. Birth of a new gene on the [ Drosophila Y chromosome. Abstracts of the 44th Annual Drosophila Research Conference; 2003. p. 113. Google Scholar]

31. Zdobnov EM, et al. Comparative genome and proteome analysis of [ Anopheles gambiae and Drosophila melanogaster. Science. 2002;298:149-159. [ PubMed] Google Scholar]

45. Carvalho AB, Clark AG. Efficient identification of [ Drosophila Y-chromosome sequences by short read sequencing. 49th Annual Drosophila Research Conference; 2008. p. 124. Google Scholar]

46. [ Drosophila 12 Genomes Consortium. Evolution of genes and genomes on the Drosophila phylogeny. Nature. 2007;450:203-218. [ PubMed] Google Scholar]

60. Boves JW, et al. Chromosomes of [ Richardiidae, Otitidae and Platystomatidae (Diptera: Acalyptratae) Genetica. 1973;44:553-571. Google Scholar]

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Origin and Evolution of Y chromosomes: Drosophila tales

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Classically Y chromosomes are thought to originate from X chromosomes through a process of degeneration and gene loss. Now, the availability of 12 Drosophila genomes provides the opportunity to study the origin and evolution of Y chromosomes in an informative ...

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How does Melanin connects to DNA and mRNA?

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How does Melanin connects to DNA and mRNA?

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Melanin is actually a protein!! Due to this fact, in order for to melanin be created, it must pass through the whole transcription and amino acid processes.

Source:

Dr. Giorgi and Ms. Barbelli

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Melanin is what protects us from the sun. In other words, it is a natural sun protector.

Source:

Dr. Giorgi and Ms. Barbelli

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Genotype is the set of characteristics that an individual carries. In comparison, the phenotype is the observable characteristic.

Source:

Dr. Giorgi and Ms. Barbelli

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Heterozygous - when there are two different alleles.
Homozygous - when there are two of the same allele.

Source:

Dr. Giorgi and Ms. Barbelli

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Dominant are "stronger" alleles, that show their effect even if there is only one copy. In turn, recessive genes are "weaker" and can only be observed if there are two copies (no dominant alleles).

Source:

Dr. Giorgi and Ms. Barbelli

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Alleles are two or more forms of a gene that arise from mutation and are found at the same place in a chromosome.

Source:
https://www.genome.gov/genetics-glossary/Allele

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Definition

An allele is one of two or more versions of DNA sequence (a single base or a segment of bases) at a given genomic location. An individual inherits two alleles, one from each parent, for any given genomic location where such variation exists. If the two alleles are the same, the individual is homozygous for that allele. If the alleles are different, the individual is heterozygous.

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An allele is one of two or more versions of a gene.

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In 1866, Gregor Mendel discovered the rules of hereditary in his garden in a monastery. He planted over 30,000 peas (during the course of eight years) and discovered that offspring inherit traits from their parents, and that certain genes appear more than others.

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When the mRNA leaves the cell nucleus and meets with tRNA, a protein is formed. That process is called translation because there is a translation between "DNA languages" to "Protein languages"

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In an era of scientific enthusiasm in the summer of 1961, the announcements of the discovery of messenger RNA (mRNA) and the decoding of the genetic code occurred weeks later. Although mRNA is crucial to our comprehension of how genes function, no Nobel Prize has been given for its discovery. Simple claims of priority may not accurately reflect how science functions, as seen by the enormous number of people involved, the complexity of the findings, and the difficult process that was followed more than 50 years ago.

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What types of mutation cause a bigger impact?

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What types of mutation cause a bigger impact?

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The insertion mutation and the deletion mutation causes a bigger impact in the amino-acid.

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What are the types of mutation that can happen?

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What are the types of mutation that can happen?

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When one nucleotide is replaced with another, it is called a substitution mutation.
For example, changing ATCG to ATAG.

When a nucleotide is added into the sequence, it is called an insertion mutation.
For example, changing ATCG to ATGCG.

When a nucleotide is lost from the DNA sequence, it is called a deletion mutation.
For example, changing ATCG to ACG.

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Mutation is when a nucleotide is changed, directly affecting the 3-3 amino acid path in order to create a protein.

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The genetic information required to produce proteins is carried by mRNA molecules. They transport the data from the DNA in the cell's nucleus to the cytoplasm, where proteins are produced. Likewise known as messenger RNA.

This whole process is called "transcription"

Sources:

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/mrna

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The instructions required to build proteins are stored in DNA. A gene's instructions are translated into messenger RNA (mRNA), which leaves the nucleus and travels to the cytoplasm. After then, a protein is produced using the information from the mRNA.

Sources:

https://learn.concord.org/

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STEM Resource Finder | Concord Consortium

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The STEM Resource Finder is a collection of the Concord Consortium's best resources for science, math, and engineering education. Our curated collections offer lesson plans and units for your class based on these resources. All for free!"

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Inside this Twisting Ladder, which actually is the DNA itself, there are 2 pairs of bonded molecules, Adenine, Guanine, Thymine, and Cytosine.

In fact, the pairs of connected molecules are:

Adenine with Thymine
Guanine with Cytosine

The 2 pairs of molecules does not connect with each other.

Source:

Dr. Giorgi and Ms. Barbelli

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The information required to create a living being is stored in the incredibly unique molecule known as DNA. The DNA in the organism's cells determines whether it has brown hair, leaves, wings, or gills. Every living thing has the ability to convert DNA information into proteins, which are collections of amino acids. This exercise will center on how the cell decodes the information stored in DNA and uses it to create the proteins the cell need. If you look closer to a DNA, you will see that it looks like a twisting ladder.

Sources:

https://kidshealth.org/en/kids/word-dna.html?scrlybrkr=1a737040#:~:text=DNA%20is%20the%20genetic%20information,looks%20like%20a%20twisting%20ladder.

https://learn.concord.org/

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The largest known star in the universe is UY Scuti. It has an estimated radius of 1.188 billion kilometers. This star is approximately 2100 times bigger than the sun.

How bizarre, right?

https://www.usatoday.com/story/tech/science/2023/02/16/largest-star-universe-red-hypergiant/11075755002/

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There are billions and trillions of stars in our universe. To put it into perspective, there are around 200 sextillion stars in the universe.

Within this expansive number are stars of all shapes and sizes. This includes the smallest star ever recorded, "EBLM J0555-57Ab," which is about the size of Saturn. But what about the biggest star in the universe?

You're going to need more than just a telescope to get a glimpse of this hypergiant star. Here is what you need to know about the biggest star in the universe and how it compares to our Sun.
In space: Almost the same size as Earth: James Webb Space Telescope confirms its first exoplanet Webb telescope reveals icy space cloud containing the 'building blocks of life'
What is the biggest star in the universe?

The largest known star in the universe is UY Scuti. It has an estimated radius of 1.188 billion kilometers. If UY Scuti were the center of our solar system, its photosphere, or outer shell, would reach just past the orbit of Jupiter.

It is a red hypergiant, meaning it has an enormous mass and luminosity. These types of stars are harder to find, however, because of their short life spans. Unlike other stars which last for billions of years, hypergiants only exist for a few million years.

UY Scuti was discovered in 1860 by German astronomers; at the time, it was named "BD-12 5055." This star can be found near the center of the Milky Way, around 9,500 lightyears away from Earth. It is a part of the constellation Scutum.

Space photos: Stunning images you have to see

Just Curious: We're here to help with life's everyday questions

Is the Sun the biggest star?

The Sun may be the center of our solar system, but it is not the biggest star in the universe. The Sun has a mean radius of around 696,000 kilometers, or 432,450 miles.
What is the coldest place in the universe: It's only *slightly* warmer than absolute zero.
In comparison to UY Scuti, the Sun's radius is 1,700 times smaller. About 5 billion Suns could fit inside UY Scuti.

Revealed: 10 satellite images tell 2022's stories from space

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What is the biggest known star in the universe? Its radius is 1700 times larger than the Sun's.

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There are billions and trillions of stars in our universe. To put it into perspective, there are around 200 sextillion stars in the universe. Within this expansive number are stars of all shapes and sizes. This includes the smallest star ever recorded, "EBLM J0555-57Ab," which is about the size of Saturn.

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Two or more atoms are securely connected to form molecules. What a molecule produces depends on the number, types, and arrangement of the atoms within it. For instance, colored carbon dioxide is created when two oxygen atoms are linked to one carbon atom to form a molecule.

Sources:

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/molecule

https://www.youtube.com/watch?v=DkAXO--BYEw

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About 4.5 billion years ago, a dense cloud of interstellar gas and dust gave rise to our solar system. The supernova shockwave from a nearby exploding star, or supernova, may have caused the cloud to collapse. This dust cloud burst into a spinning disk of material known as a solar nebula when it disintegrated.

Sources:

https://kids.britannica.com/kids/article/solar-system/353789#:~:text=The%20solar%20system%20was%20formed%20about%204.7%20billion%20years%20ago,that%20it%20got%20very%20hot.

https://www.amnh.org/exhibitions/permanent/the-universe/planets/formation-of-our-solar-system

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- Expancion started (?)
- Mass was created
- Few Minutes
- Hot
- Dense
1- 4 billion years ago
- Elements were made in less than a second
I- t will stop to expand
- It will explode one day very far away

Sources:

https://www.youtube.com/watch?v=TzhIfN4UQv8

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The record suggests that all life on Earth emerged from primitive cellular colonies which first appeared roughly three and a half billion years ago.

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This idea is based on many observations, one of which is that when living things reproduce, children are often born with random new traits. Those with negative new traits are less likely to survive and reproduce, those with positive new traits are more likely to survive and pass those traits on to their children. Over multiple generations, positive traits build up allowing relatively simple life forms to evolve into complex life forms and even split into multiple different species. A careful look at the fossil record overwhelmingly confirms Darwin's theory. Life forms get simpler and simpler as we go back in time.

Source:

https://www.youtube.com/watch?v=fgQLyqWaCbA

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0:00 / 7:10•Watch full video

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What does Darwin's theory of Biological evolution tell us?

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What does Darwin's theory of Biological evolution tell us?

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Darwin's theory of Evolution tells us that all living things evolved from a single and simple reproducing creature that lived in the distant past.

Source:

https://www.youtube.com/watch?v=fgQLyqWaCbA

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Sorry, we've retired the page you were looking for | Science Museum of Minnesota

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Sorry, we've retired the page you were looking for

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The Stellar Nebula was created when hydrogen atoms gathered together. This Stellar Nebula is capable of producing stars of various sizes. When common stars run out of fuel, Red Giants are formed. As a result of enormous stars running out of fuel, Red Super Giants can develop. Planetary nebulas are created when Red Giants become unstable and erupt. All of the material from these nebulas is compressed together to form White Dwarfs, a compact star. The atom’sselectrons were removed as a result of gravity drawing them together closer. The mass is comparable to that of the Sun, and the volume is comparable to that of the Earth for ease of imagining.

Source:

Dr. Giorgi and Ms. Barbelli's slides.

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Whenever the Atom has the same number of Protons, Neutrons, and Electrons, the atom is at the neutral stage.

Sources:

The Elements Game.

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Because they establish the structure of all the matter in our environment, atoms are crucial. The essential building components of any material or matter are molecules, which are created when atoms join to form them. It is impossible for molecules, elements, and stuff to exist without atoms.

Sources:

https://homework.study.com/explanation/what-are-atoms-and-why-are-they-important.html#:~:text=Atoms%20are%20important%20because%20they,and%20matter%20is%20not%20possible.

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An element is an atom determined by the number of protons. For example, the "cobalt" element is composed of 27 protons. In fact, if you add 2 protons to the "cobalt" element, you will create copper.

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The tiniest piece of something that cannot be destroyed chemically. The center of every atom is called the nucleus, and it is made up of protons and neutrons (particles with no charge). The nucleus is filled with electrons, which are negative particles.

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An atom is simply made of Protons, Neutrons, and Electrons.

Where each particle is located in the atom?

Protons and Neutrons are located inside the nucleus of the atom. However, the Electrum particle is located at the cloud of an atom.

SOURCE:

Thaís Boccia.

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Here is the link of the TimeLine about the important events after the Big Bang.

https://padlet.com/joaoportilho26/big-bang-timeline-r1gdszlhsy4r625f

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A neutron is a neutral atomic particle that, with the exception of the hydrogen nucleus, is found in all known atomic nuclei and has a mass that is almost identical to the proton.

Fun Fact about Neutrons, there is a star fully made of neutrons! When a big star runs out of fuel and collapses, neutron stars are created. The core of the star, which is its most central portion, collapses, fusing every proton and electron into a neutron.

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A tiny, negatively charged particle that exists in every atom. Radiation therapy can make use of electron streams produced by specialized equipment.

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Atomic mass is simply the quantity of matter contained in an atom of an element. For example, the atomic mass of the Titanium element is 47.867. This means that this element accommodates approximately 48 u.

What is a fun fact about atomic mass?

One fun fact about atomic masses of elements is that the atomic mass is always extremely near to the mass number since each proton or neutron weighs approximately 1 amu (total number of protons and neutrons in the nucleus).

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HOW DO QUARKS CREATE PROTONS AND NEUTRONS? | HOW PROTONS AND NEUTRONS ARE CREATED?

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HOW DO QUARKS CREATE PROTONS AND NEUTRONS? | HOW PROTONS AND NEUTRONS ARE CREATED?

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In order to create a proton, you must combine two up quarks and one down quark. Alternatively, to create a neutron, you should combine one up quark, and two down quarks.

Why does that happen?

The value of an up quark is 2/3,  and the value of a down quark is -1/3. We know that neutrons are neutral (so they are not negative nor positive) and that protons are only positive (=1). Due to this fact, those are the equations to prove why we need these exact types of quarks to calculate hadrons:

Protons = 2/3 + 2/3 + (-1/3)
Neutrons = 2/3 + (-1/3) + (-1/3)

SOURCES:

https://www.energy.gov/science/doe-explainsquarks-and-gluons#:~:text=In%20this%20plasma%2C%20the%20density,froze%20into%20protons%20and%20neutrons.

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A proton is a tiny particle that is found in the nucleus of an atom. Everything that you can touch, hold or feel is made of atoms, these are the smallest building blocks of solids, liquids and gases. There are many different types of atoms, and each type forms a different element.

Download FREE teacher-made resources covering 'proton'

The number of protons in an atom determines what type of element the atom is. The periodic table groups atoms according to how many protons they have. The number of protons in the nucleus of an atom is referred to as the atomic number. Atoms are made up of protons and neutrons in the nucleus, which is orbited by electrons.

Protons are similar in weight to neutrons, which are also part of the structure of an atom. Unlike neutrons which have a neutral charge, protons are positively charged. Most of the mass of an atom is in the proton, in fact protons are almost two thousand times heavier than electrons.

What are Protons made of?

Protons are made of quarks. There are two types of quarks that can be found naturally inside normal matter. These are called up quarks and down quarks. Protons are believed to be made of 3 quarks, two up quarks and one down quark.

Who discovered Protons?

Protons were discovered by a physicist called Ernest Rutherford in 1920. Rutherford is known today as the father of nuclear physics, as he not only discovered that protons exist, but he was also the one who first proved that atoms have a nucleus. He also proved that atoms were mostly made up of empty space.

History of Protons

As early as 1815, a scientist called William Prout proposed the idea that all atoms are made of hydrogen atoms, which he called 'protyles'. In 1886, another scientist called Eugen Goldstein proved that there were positively-charged particles being produced from certain gases. Then, in 1897, yet another scientist called Joseph John Thompson discovered electrons, the negatively charged particles that make up an atom.

Ernest Rutherford did many experiments related to atoms between 1919 and 1925, and he was able to discover that hydrogen was the simplest and lightest element. As he was influenced by Prout's 'protyles' idea, Rutherford originally suggested that hydrogen, as the simplest and lightest element, contained only one of these particles. He named this particle the 'proton' after the Greek word for ' first'.

Over time, research conducted by Rutherford and other scientists slowly improved our knowledge of the structure of atoms. In 1927, a scientist called James Chadwick proved the existence of neutrons, or particles with neutral charge that also make up the nucleus of an atom alongside protons.

How big are Protons?

Because atoms are tiny, and protons make up just a small part of an atom, protons are extremely small. In fact, if an atom was scaled up to be the size of a basketball stadium, a proton would only be the size of a small marble. Despite the fact that atoms make up every solid thing we can see and touch, Rutherford proved that atoms are actually mostly empty space. Protons are a very important aspect of the structure of an atom's nucleus, and the number of protons indicates what element the atom is. However, protons only make up a very small amount of the atom itself.

Interesting Facts About Protons

Thunderstorms can produce protons that are filled with energy

Protons are used for experiments, such as the research related to the Large Hadron Collider

The three quarks that make up a proton are always moving, so a proton isn't a solid object, it is an area in which the quarks move

In any atoms of the same element, the number of protons is always the same

The protons and neutrons in the nucleus of an atom are held together by a strong nuclear force

Proton Resources Are Available to Download

If you are teaching a lesson about protons, there is a diverse variety of resources that you can choose from to download and include in your lesson plan. For example, this KS3 Atoms, Elements, Compounds and Mixtures Revision Pack is a fantastic resource to use for teaching about protons.

You can also download this set of History of the Atom Information Posters. These display resources contain lovely hand-drawn illustrations and diagrams to make them as eye-catching and engaging as possible. If you are covering the topic of protons in your lesson, these display posters make a wonderful educational resource that you can use to decorate your classroom.

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What are Protons? Find out everything children need to know about protons

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A proton is a tiny particle that is found in the nucleus of an atom. Everything that you can touch, hold or feel is made of atoms, these are the smallest building blocks of solids, liquids and gases. There are many different types of atoms, and each type forms a different element.

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The tiniest component of an atom's nucleus is known as a proton. Atoms are the tiniest units of solids, liquids, and gases that make up everything you can touch, grasp, and feel. A separate element is formed by each of the several sorts of atoms.

However, what happens to an element when you add a proton to it?

Let's use the example of Iridium. If you collect two protons and add them to the Iridium element, you will create gold. Iridium contains 77 protons. In fact, gold is made of 79 protons, so if you attach 2 protons to the Iridium, it will become gold.

SOURCES:

https://www.twinkl.com.br/teaching-wiki/proton#:~:text=is%20a%20proton%3F-,Proton,type%20forms%20a%20different%20element.

https://www.britannica.com/science/proton-subatomic-particle

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The temperature decreased below 1 billion degrees Celsius after 3 minutes of the explosion itself. The temperature had dropped enough for the hydrogen and helium nuclei to form as the protons and neutrons were combined.

The universe had cooled to around 3000 degrees after 300,000 years. Finally, atomic nuclei could pull in electrons to create atoms. Hydrogen and helium gas clouds were everywhere in the universe.

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Energy transformed into matter and antimatter particles as the universe cooled and expanded. These two completely opposite particle kinds largely eliminated one another. But some material did escape. When the Universe was just one second old, protons and neutrons (more stable particles) began to form.

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The fundamental particle connected to the Higgs field—a field that supplies mass to other fundamental particles like quarks and electrons, is the Higgs boson. The amount that a particle resists changing its speed or position in response to a force depends on its mass. Not all fundamental particles have mass, like photons and gluons.

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Quark is what comes before everything, even before protons and neutrons. Actually, a quark is what forms protons and neutrons. To form those hadrons, you must combine quarks themselves, usually 3 of them. However, is it just combining 3 of them?

There are SIX types of quarks, which are popularly known as flavors. Those are up, down, strange, charm, bottom, and top.

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Another one is microwave background radiation. When the universe was created, radiation also started going everywhere in space that they had (expansion was already happening). Due to this fact, there is a type of telescope that allows us to see the waves that are running into space. Using this telescope, we can calculate to have an approximately estimative of how old the wave is.

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According to ESA, most astronomers believe the Universe began in a Big Bang about 14 billion years ago. At that time, the entire Universe was inside a bubble that was thousands of times smaller than a pinhead. It was hotter and denser than anything we can imagine. Then it suddenly exploded.

The known universe was created. The Big Bang marked the beginning of time, space, and matter. The Universe grew from being less than a single atom to being larger than a galaxy in a few seconds. And it continued to expand at an amazing rate. Even now, it is still growing.

Sources: https://www.esa.int/kids/en/learn/Our_Universe/Story_of_the_Universe/The_Big_Banghttps://www.esa.int/kids/en/learn/Our_Universe/Story_of_the_Universe/The_Big_Bang

https://www.space.com/big-bang-first-few-seconds

https://home.cern/science/physics/early-universe#:~:text=In%20the%20first%20moments%20after,which%20we%20are%20all%20made.

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- The Big Bang started 14 billion years ago?

- Were elements made in less than a second?

- Did Big Band set motion?

- When did expansion start?

- What is a light year?

- Galaxies were formed right after the explosion of the Big Bang?

- Math

- Were planets formed right after a few minutes from the Big Bang?

- What was the process of the explosion of the Big Bang?

- How old is the sun?

- What about neutrons?

- What about protons?

- What about electrons?

- What are quarks?

- What is one piece of evidence of the Big Bang?

- When is the Earth stopping to expand?

- Did colors already exist?