# data[].attributes.body
Cryptococcus neoformans  leads to meningitis or disseminated disease, especially in persons with defective cell-mediated immunity.

Cryptococcosis represents a major life-threatening fungal infection in patients with severe HIV infection.

Meningitis and meningoencephalitis, the most common manifestations of CNS cryptococcosis, are usually subacute or chronic in nature. HIV-infected patients may have minimal or nonspecific symptoms. Common symptoms are as follows:

Headache

Confusion

Lethargy

Obtundation

Coma

Normal or mildly elevated temperature

Nausea and vomiting (with increased intracranial pressure)

Fever and stiff neck (with an aggressive inflammatory response; less common)

Blurred vision, photophobia, and diplopia

Hearing defects, seizures, ataxia, aphasia, and choreoathetoid movements

https://emedicine.medscape.com/article/215354-overview#a1

# data[].attributes.body
use carbon dioxide to build up organic food materials. They are, thus heterotrophic for carbon (organic) food compounds which they in their natural habitats obtain by living as saprophytes or parasites from dead or living plants, animals or micro-organisms or their wastes.

# data[].attributes.body
Higher order taxa

Eukaryota (Kingdom); Fungi (Domain); Basidiomycota (Phylum); Tremellomycetes (Class); Tremellales (Order); Tremellaceae (Family); Cryptococcus (Genus)

https://microbewiki.kenyon.edu/index.php/Cryptococcus_neoformans

# data[].attributes.body
*Has a well-defined bipolar mating system with two opposite mating types.
*MATa and MATα can also undergo homothallic unisexual reproduction from one single cell or between two cells of the same mating type.
*Asexual reproduction takes place either by budding or, in case of MATα cells, by haploid fruitting *Sexual reproduction occurs when cells of opposite mating types come together to form a heterokaryon that ultimately leads to production of basidia and basidiospores.

# data[].attributes.body
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698900/

# data[].attributes.body
Spherical, encapsulated, non-myceliated, non-fermenting fungal cell.

Grows as a yeast and replicates by budding

Surrounded by mucopolysaccharide capsule (mucinous capsule)

Produce phenol oxidase

Form pseudo- or true hyphae

Vacuoles were present in C. neoformans and are
limited by a single unit membrane of the type
frequently described for fungi, as, for example, in
Saccharomyces cerevisia