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May be useful model for development of personalized anti-depressant therapies for treatment resistant depression 

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May be useful model for development of personalized anti-depressant therapies for treatment resistant depression 

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WKY appears to be resistant in early life manipulations (neonatal handling) that are therapeutic in other strains

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Animal model for treatment-resistant depression 

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Animal model for treatment-resistant depression 

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WKY rat appears to be insensitive to some common antidepressant compounds

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Use to understand the neurobiology underlying anxiety and depression 

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Use to understand the neurobiology underlying anxiety and depression 

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Genetic  model  of  depression,  displays  sex differences  in  response  to  antidepressants

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Used extensively in physiological studies relating to hypertension 

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Used extensively in physiological studies relating to hypertension 

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WKY serve as normotensive control for SHR strain. Both share same genetic background, from Wistar ancestor

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Significantly immobile during proestrus-estrus than diestrus phase

Exhibiting more signs of behavioral depression in FST

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Less active during proestrus-estrus than diestrus phase

More emotional in OFT

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More pronounced during proestrus-estrus phase than diestrus phase

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WKY females rats are more active in OFT, but more immobile in FST compared to WKY male rats

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WKY female rats have progressively decreased in food consumption, whereas feeding WKY male rats returned to control levels after five stress days

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Female WKY rats are more vulnerable to chronic stress and stress induced behavioral depression than male rats

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Depressive-like behaviour of WKY males was observed from early adolescence while female WKY, it appeared only in adulthood.

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Common Tests to Assess Physiological and Behavioral Changes 

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Common Tests to Assess Physiological and Behavioral Changes 

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What Is Wistar Kyoto Rats? Its Origin? Taxonomy?

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What Is Wistar Kyoto Rats? Its Origin? Taxonomy?

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*Other factor affecting vulnerability to stress in WKY female is ESTRUS CYCLE. Steriod hormone milieu in WKY rats may be responsible for these behavioral changes

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Tap this photo to see other details on the sex differences!

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The WISTAR KYOTO (WKY) strain is an inbred strain.

Derived from the same parental Wistar rats stock

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Why is it named as WISTAR KYOTO (WKY)?

In 1960, Okamoto at Kyoto University selected Wistar rats based on expression of spontaneous hypertension Wistar animals with "normal" blood pressure (normotensive) selected to be used as same-genetic background of spontaneous hypertensive rats (SHR)

In short;

1. SHR: Wistar ancestor, hypertensive

2. WKY: Wistar ancestor, normotensive control for SHR

3. Wistar: Outbred albino rats

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Albino rat

Characterized by its wide head, long ears, and having a tail length that is always less than its body length

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A rodent behavioral test to detect antidepressant activity. Depressive-like behavior will exhibit immobility  in inescapable container filled with water

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Scientific classification of Wistar Kyoto rats

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Simple sensorimotor test to determine general activity levels and gross locomotor activity in rodent of CNS disorders.

WKY rats place in a square, white Plexiglas box.

Results:

Hypoactive, highly immobile in OFT

Suggest the presence of depressive behavior