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Electrical fast- connecting cells (gap junction)

Chemical slow- need to cross synaptic cleft

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Electrical is through gap junctions while chemical is through synapses

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Electrical: fast, uses connexins and gap junctions. Chemical: slow transmission, examples: ionotropic/metabotropic.

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BZD binding site and barbiturates

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Benzodiazepine receptor

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BZD, Flumazenil, and ethanol all have binding sites. Flumazenil will reverse BZD

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GABA is an inhibitory neurotransmitter

benzodiazepine binding site inhibits anxiety and stress

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I need more AMPA receptors :(

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Parkinson’s disease

Degradation of neurons in substantia nigra

Less dopamine receptors

Tremors.

Dementia with Lewy bodies

Buildup of proteins affect dopamine transmission.

Visual hallucinations

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Substantia nigra is the Kim Kardashian of dopamine production

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Substantia nigra is the Kim Kardashian of dopamine production

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Dopamine has to do with PD Dementia (lewy body). Hallucinations are special for dementia. Dopamine is important for movement initiation and termination.

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Alzheimers ACh

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Amyloid plaques

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Alzheimer’s- tau tangles and beta amyloid plaques!

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GBS- rapidly damaged peripheral neurons

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Lambert Eaton and lung cancer

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Inverted Champagne bottle

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2nd decade of life

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Smoking history (exposed to smoke)

usually presents with dry mouth, and may have small cell lung cancer. Parasthesia usually starts in the lower extremities and works it's way up

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CMT has high arch in foot and champagne bottle appearance in the lower leg

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GBS: attack on myelin sheath in the periphery. More likely when exposed to viruses like COVID and ZIKA.

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CMT- X-linked