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Fever from injected drugs.Another noteworthy example concerns the development of the polio vaccine. Researchers spent decades infecting non-human primates with the disease, and conducting other animal experiments, but failed to produce a vaccine.

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A pyrogen test explanation rabbits are restrained and injected with a test substance while their body temperature is monitored for changes that suggest the substance might be contaminated with pyrogens.

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Rabbit pyrogen test becomes standard. If a pyrogen is present in the test substance, it will cause an elevation of the animal's body temperature from normal. Rabbits have similar temperature response to endotoxins as humans. For this reason, they are ideal for use in pyrogen detection.

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Horse shoe crab test invented. If a pyrogen is present in the test substance, it will cause an elevation of the animal's body temperature from normal. Rabbits have similar temperature response to endotoxins as humans. For this reason, they are ideal for use in pyrogen detection.

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Fever horseshoe crab. Bang was studying the circulation of blood using horseshoe crabs when he found that one of his crabs died as a result of a Vibrio bacterial infection. The infection caused a strange disease in which almost the entire blood volume of the crab clotted into a semi-solid mass.

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Horseshoe crab test became standard. By the 1990s, LAL was the FDA-approved method for testing medicines for endotoxin, largely replacing rabbits. Producing LAL requires harvesting horseshoe crabs from oceans and beaches, draining up to 30% of their blood in a laboratory and returning the live crabs to the ocean.

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Monocyte activation test (MAT) invented. The Monocyte Activation Test (MAT) is a cutting-edge in-vitro assay that employs human blood to replicate the early stages of the human immune system. This innovative test is designed to detect all types of pyrogens in parenteral drugs, biologics, and medical devices.

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90% testing with horseshoe crab, but still 300,000+rabbits per year.

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OECD(organization for economic cooperation and development) approves another non-animal alternative test for dermal corrosivity(Dermal Corrosion is the production of irreversible damage of the skin).

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Completion of human Genome project. The Human Genome Project, completed in 2003, covered about 92% of the total human genome sequence. The technologies to decipher the gaps that remained didn't exist at the time. But scientists knew that the last 8% likely contained information important for fundamental biological processes.

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80% less rabbits tested in EU. Though the number of animals used for cosmetic testing has been greatly reduced, there are still some products like sunscreens, antidandruff shampoos, fluoride-containing toothpastes, and anti-acne creams that cannot be proven safe without the use of animal testing because they contain ingredients that cause a chemical.

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(PREDICTION) No more rabbits tested in EU