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Rhinits:Inflammation of nose
Allergic rhenetis:irrititaion of the mucus membrane
Two types of allergic rhenitis
Seasonal Allergic rhenitis
Periphennal Allergic Rhenetis
India 15to 30% population Suffer from allergic rhenetis
IGE:immuno globulins E
Bilastine has dual action h1 receptor antagonist and il4 secretion
Bilastine and montelukast has triple action by antihistamine, Antiinflamtory,Bronchodilator
WAO:world Allergic
organisation
MDS:matrix tablet directly compressed stable product
Usp of bilastine:
Onset of action
Long duration of action 26hrs
5 times better than fexofenadine
3 times better then cetrizine

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Bilazap m contains bilastine 20 mg + Montelukast 10 mg
Bilastine provides higher selectivity to H1 receptor then levo and fexo. 3 times higher then levo and 5 time more potent then fexo .. score 10/10 in ARIA guideline, safest antihistamine till date safe for renal hepatic cardio patient also... Safe for comvorbit patient also you can give without any dose adjustment. Drug to drug interactions also less. Done not metabolise in liver . In our Bilazap m we have MDS technology for better absorption of molequle and provide dosages accuracy.. quick symptomatic relief around 30 minutes. Fast on set of action. Low sedation done not penetrate BBB. Safest antihistamine for drivers and pilots also .. dose OD 1 hr before or 2 hr after food.. you can use like ppi also before breakfast.

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What is Allergic Rhinitis
allergic rhinitis symtoms
allergic rhinitis Classification
seasonal and Perennial Allergic Rhinitis
classification of allergic rhinitis as per ARIA guidelines
Treatment Of AR as per ARIA

the phase of Allergic Rhinitis
Early and Late

What are the Available Medication for Allergic Rhinitis

Different Generations of Antihistamines
first-generation and second
Levocetirizine
montelukast
cetirizine

How Bilastine better than Fexofenadine and Cetrizine

bilastine with superior Efficacy and Safety Profile

Rapid on-set action
truly Non-sedative
Higher Selectivity
Bilastine 26 hrs of Action

how Bilastine and Montelukast combination better for AR

How Montelukast is Working.

BILAZAP - M USP's
triple Action Of anti Histamins, Anti Inflammatory, Bronchodilator

Mode of action - it offers dual action, it is an H1 receptor antagonist and inhibits IL 4 secretion also

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Allergic Rhinitis -Disorder of the nose

-It's the inflammation of the lining of the nose & is characterized by nasal symptoms like rhinorrhea, sneezing, nasal blockage &/or itching nose.

Note-Uncontrolled AR can lead to Asthma. Therefore treatment of it is vital.

Treatment as per ARIA guidelines-
Mild intermittent-H1 blocker
Mod to severe-Oral H1 or LTRA
Mild persistent-oral H1 or LTRA
Mod severe-LTRA

Class of drugs used-oral H1 blockers-1st-Cetrizine,2nd-Fexofenidine & 3rd-Bilastine

Bilastine controls early-phase rhinitis-1.Affinity-3x more than cetirizine,5x more than fexofenadine
2.Persistence-5 to 10 times greater than cetirizine
3.Potency-4 to 11 times greater than fexo & cetirizine

Bilastine USPs-doesn't cross BBB, short persistence to brain H1 receptors can be used for patients with contraindications

Bilastine-Inhibit IL-4,blocks histamine & WBC release

Dosage-20mg OD one hour before or two hours after

Bilastine M- 3-way action of anti-inflammatory,anti-histamine & bronchodilatory.

Montelukast-LTRA, anti-inflammatory

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Allergy is a hypersensitivity to allergens which trigger allergic response is called allergy.
Allergic rhinitis is an inflammation or irritation of the mucous membrane.
This is body's immune response over infectious particles .(allergens)
Classification
Intermittent
Persistent
Mild
Moderate
Mast cell-->outer membrane brekdown-->phispholipids--> Arachidonic Acid--> Leukotriene release--> IL5 release-->Inflammation.
As per aria guidelines
Intermittent
Persistent
Bilastine(H1 receptor)
Affinity 3 times over cetrizine
5 times vs Fexofenadine
Dose Bilazep M
1hr before meal or 2 hr after meal
Bilastine have 0% occupancy in brain due to that no sedation is there and not disturbed daily life.
Bilastine recommend by WAO
beacuse have
Superior efficacy and safety
Recommend for allergic or high risk rhinitis
Higher selectivity to H1
Longer duration of action.
Cardio safe.

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Allergy- Hypersensitivity to allergens which triggers allergic response is called Allergy.
Rhinitis- Inflammation of Nose.
Allergic Rhinitis- Disorders of Nose.
Cause of AR - 1.sneezing,2. Rhinorrhea,
3. Nasal Congestion etc.
Pathology of AR- 1. Early Allergic Response- within 3 min.
2. Late Allergic Response- within 30 to 60 min.
Types of AR - 1. Seasonal AR - it may occurs seasonal allergens.
2. Perennial AR- it may occurs more than 9 month.
Bilastin - H1 receptor antagonist and inhibits IL- 4 Secretion.
Bilazap - Bilazap contains Bilastin 20 mg tablet.
Dosage- 1 tablet OD
Usp-1. onset of action within 30 mint,
2. 3 times greater affinity for H1 receptor vs Certrizine
3. 5 times greater affinity for H1 receptor Vs Fexofenadine
4. Bilastin recommented by ARIA and WAO

Montelukast - potent and selective leukotriene receptor antagonist
Bilazap- M - Contains Bilastin 20 mg and Montelukast 10 mg tablet.
Dosage- One hour before two hour after food (OD)
Usp- safest combination of Diabetic, renal, hapatic patient.
Triple action anti- Histamine, anti- inflammatory and bronchodilatory.

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1. Alergy Rhinitis - Allergen in nose mucous membrane which causes inflammation and Which further develops to Asthma in future.
2. 40% of the population stuffers perennial AR and 40% both seasonal and perennial AR
3. Early Allergy response within 3 min and Histamine release from mast cell and thus release IL 4 and leukotrienes,  where Ig E gets attached with H1 receptor and cause inflammation, sneezing, rhinoria
4   Late Allergy response within 30 min and Histamine release from mast cell and release cytokines that attack leukotrienes and WBC which causes nasal mucosa, congestion inflammation.
5    Seasonal AR - Seasonal Allergen , tree pollens
6  Perennial AR - Cronic causes throughout the year
60ARIA GUIDELINES
Intermittent 4days -4 weeks mild symptoms
Persistent - more than 4weeks moderate sever symptoms
7 Drug used in AR - bilastine , fexofenadine, levocetrizine , cetrizine
Bilastine
8 Approved by EMEA ,DCGI , ARIA , WAO ,
9 Bilastin
Mode of action - it offers dual action , it is H1 receptor antagonist and inhibits IL 4 secreation also
10 montelucast
Mode of action H 1 receptor antagonist and IL 4 secreation

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Alergic Rhinits:-
Inflammation in the nose

Type Of AR:-
1.Seasonal AR:-occur during seasonal allergens
2.Perennial AR:-more than 9 months in a year

Symptom Of AR:-
-snezzing
-rhinorreha
-nasal congestion
-snorting
-throat clearing

Path of AR:-
Early Allergic response:-within 3 minute
late Allergic response:-30to60 minute

Bilastine:-
highly selective h1 receptor

3time more affinity vs cetrizine
5time more affinity vs fexofenadine

duration of action upto 26 hrs

4 to 11 time higher potency vs cetrizine and fexo

MOA:-
h1 receptor antagonist and inhibits IL-4 secretion

bilastine does not cross BBB due to less sedation

faster on set action within 30 minute

dose:-1 tab od 1 hrs before meal and 2 hrs after meal

no dose adjustment require in renal impairement

Bilazap M:-

Montelukast:-

potent and selective leukotriene receptor antagonist

triple action anti histamine,anti inflammatory,bronchodilator