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Smoking is the act of inhaling and exhaling the fumes of burning plant material. A variety of plant materials are smoked, including marijuana and hashish, but the act is most commonly associated with tobacco as smoked in a cigarette, cigar, or pipe. Tobacco contains nicotine, an alkaloid that is addictive and can have both stimulating and tranquilizing psychoactive effects. The WHO estimated that in the late 1990s there were approximately four million tobacco-caused deaths per year worldwide. This estimate was increased to approximately five million in 2003 and six million in 2011 and was expected to reach eight million per year by 2030. An estimated 80 percent of those deaths were projected to occur in developing countries.