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https://ghr.nlm.nih.gov/condition/cri-du-chat-syndrome

https://rarediseases.info.nih.gov/diseases/6213/cri-du-chat-syndrome

https://www.genome.gov/19517558/learning-about-cri-du-chat/

https://rarediseases.org/rare-diseases/cri-du-chat-syndrome/

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https://fivepminus.org

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Cri du chat awareness day is on May 5th, created by the governor of Massachusetts to bring about a better understanding of the disorder.

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This disorder appears in about 1 out of 20,000-50,000 people born in the US.

This disorder can affect all genders and races.

There are over 1,000 families in the US dealing with Cri du chat syndrome.

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Currently there is no treatment for Cri du chat syndrome, but patients may receive supportive care. The care may include physical therapy, speech therapy, ophthamology, dietary assistance, and occupational therapy.

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Diagnosis for Cri du chat syndrome occurs shortly after birth if the symptoms are shown.

X-rays can also show defects in the shape of the base of the skull (microcephaly) which occurs naturally with this disorder.

Genetic testing is often done to ensure the presence of Cri du chat syndrome.

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Children with Cri du chat syndrome often have small jaws, webbed feet or toes, a line across the palm of their hand, short attention spans, and hyperactivity.

They also have difficulty in language and learning communication skills.

Some will have difficulties walking, scoliosis, and/or organ defects.

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Cri du chat syndrome stems from a missing section from "chromosome 5" in the DNA. It is not received from the parents, but simply occurs when there is an error in fetal development.

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Cri-du-chat is the French term for "cat cry". The name comes from the loud cat-like scream that children with this disability often emit.

It is also known as Chromosome 5p deletion syndrome, 5p minus syndrome, or cat cry syndrome.

It is not an inherited disorder.

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Children with cri du chat syndrome often show symptoms of:
-a high-pitched cat-like scream
-unique facial features like wide-spread eyes
-mental retardation
-little muscle mass
-low birth weight

Cri du chat syndrome also results in a lack of delta catenin (the CTNND2 gene that plays a vital role in Brain Synapses, development of the brain, cell to cell communtication, and guiding nerve cells to their proper position) in the brain.