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Mary was born in Cleveland, Ohio, on December 17, 1913, to John Adam Keller and Catherine Josephine Keller.

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the Sisters of Charity of the Blessed Virgin Mary

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the Sisters of Charity of the Blessed Virgin Mary

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She entered the Sisters of Charity of the Blessed Virgin Mary in 1932

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She took her vows with that religious congregation in 1940.

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She received her Bachelor of Science in Mathematics in 1943

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Keller received her Master of Science in Mathematics and Physics in 1953 from DePaul University in Chicago.

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She earned her Doctor of Philosophy from the University of Wisconsin–Madison in 1965.

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Mary began working at the National Science Foundation workshop in 1958 in the computer science center at Dartmouth College.

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After finishing her doctorate in 1965, Keller founded the computer science department at Clarke College.

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At the ACM/SIGUCC User Services Conference in 1975, Keller declared "we have not fully used a computer as the greatest interdisciplinary tool that has been invented to date."

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Keller died on January 10, 1985, at the age of 71.