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How much drug substance in total? Remain the same dosage? 

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How much drug substance in total? Remain the same dosage? 

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What time points would be sampled when dosing SC and orally?

# data[].attributes.subject
What time points would be sampled when dosing SC and orally?

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How many rats for all three treatments?

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How many rats for all three treatments?

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Can you do a cross-over study? Or different animals for each treatment?

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Can you do a cross-over study? Or different animals for each treatment?

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What volume for IV injection if solubility is 10 mg/mL

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What volume for IV injection if solubility is 10 mg/mL

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What is the maximum volume for oral gavage in rats?

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What is the maximum volume for oral gavage in rats?

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What is the maximum injection volume for SC administration in rats?

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What is the maximum injection volume for SC administration in rats?

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Fast clearance

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too much spacing between sample collection 

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too much spacing between sample collection 

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Need more intervals?

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experiment shouldve been let to run longer ?

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experiment shouldve been let to run longer ?

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there is too less data points, graphs looks very spaced out

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Add More Time Points Shortly After Dosing

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0, 2, 5, 10, 15, 30, 45, 60, 90

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0, 4, 8, 16, 24, 48, 72, 144

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0,1,2,3,6,12,24,48,96..

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microsampling to reduce volume of blood taken

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microsampling to reduce volume of blood taken

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replicate sampling

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serial sampling: use larger animals and take multiple samples from the same animal (ethical if blood volume limits are respected)