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He was born on August 13, 1755 in Cañete. He was a Peruvian precursor to indenpendence and also, a prominent Criollo doctor.

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In 1777 he moved to Lima and  enter to the university Mayor of San Marcos. In 1807, he was nombrated Protomédico General and the next year he founded the Colegio de Medicina San Fernando.

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He returned to Lima in 1816 to dedicate himself to his professional, teaching and care tasks, but, in search of rest, he moved to Cañete until 1820.

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He was minister of finance in 1821, also minister of government and Foreign Relations in 1825 and president of the government Council.

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On October 10, 1825, he was awarded the civic medal with the bust of Bolívar.

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He was one of the sixty-five deputies elected in 1825 by the Supreme Court and summoned to approve the Vitalicia Constitution of the dictator Simón Bolívar. However, he himself decided not to assume any kind of attributions and did not get to take office.

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In 1829, at the request of the viceroy, the royalist delegation that met in Miraflores with the emissaries of General José de San Martín was integrated as secretary.

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Hipolito Unanue y Pavon died on July 15, 1833 at the age of 78 in San Vicente de Cañete.