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https://www.ncbi.nlm.nih.gov/m/pubmed/31266030/?i=1&from=tdcs,%20autism

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https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/nyas.13098

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Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here

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Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here

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pnas.org

Cognitive and neural foundations of religious belief

Dimitrios Kapogiannis, Aron K Barbey, Michael Su, Giovanna Zamboni, Frank Krueger, Jordan Grafman

Proceedings of the National Academy of Sciences 106 (12), 4876-4881, 2009

We propose an integrative cognitive neuroscience framework for understanding the cognitive and neural foundations of religious belief. Our analysis reveals 3 psychological dimensions of religious belief (God9s perceived level of involvement, God9s perceived emotion, and doctrinal/experiential religious knowledge), which functional MRI localizes within networks processing Theory of Mind regarding intent and emotion, abstract semantics, and imagery. Our results are unique in demonstrating that specific components of religious belief are mediated by well-known brain networks, and support contemporary psychological theories that ground religious belief within evolutionary adaptive cognitive functions.

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Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here

Evdokia Anagnostou, Margot J Taylor

Molecular autism 2 (1), 4, 2011

Autism spectrum disorder (ASD) refers to a syndrome of social communication deficits and repetitive behaviors or restrictive interests. It remains a behaviorally defined syndrome with no reliable biological markers. The goal of this review is to summarize the available neuroimaging data and examine their implication for our understanding of the neurobiology of ASD.

Although there is variability in the literature on structural magnetic resonance literature (MRI), there is evidence of volume abnormalities in both grey and white matter, with a suggestion of some region-specific differences. Early brain overgrowth is probably the most replicated finding in a subgroup of people with ASD, and new techniques, such as cortical-thickness measurements and surface morphometry have begun to elucidate in more detail the patterns of abnormalities as they evolve with age, and are implicating specific neuroanatomical or neurodevelopmental processes. Functional MRI and diffusion tensor imaging techniques suggest that such volume abnormalities are associated with atypical functional and structural connectivity in the brain, and researchers have begun to use magnetic resonance spectroscopy (MRS) techniques to explore the neurochemical substrate of such abnormalities. The data from multiple imaging methods suggests that ASD is associated with an atypically connected brain. We now need to further clarify such atypicalities, and start interpreting them in the context of what we already know about typical neurodevelopmental processes including migration and organization of the cortex. Such an approach will allow us to relate imaging findings not only to behavior, but also to genes and their expression, which may be related to such processes, and to further our understanding of the nature of neurobiologic abnormalities in ASD.

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2wöchiges treatment des MPFC mit TMS verbessert soziale Defizite 

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2wöchiges treatment des MPFC mit TMS verbessert soziale Defizite 

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https://www.ncbi.nlm.nih.gov/m/pubmed/24280031/?i=10&from=enticott,%20autism%20rtms

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A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders

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A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders

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Recent years have seen a rapid increase in the investigation of autism spectrum disorders (ASD) through the use of functional magnetic resonance imaging (fMRI). We carried out a systematic review and ALE meta-analysis of fMRI studies of ASD. A disturbance to the function of social brain regions is among the most well replicated finding. Differences in social brain activation may relate to a lack of preference for social stimuli as opposed to a primary dysfunction of these regions. Increasing evidence points towards a lack of effective integration of distributed functional brain regions and disruptions in the subtle modulation of brain function in relation to changing task demands in ASD. Limitations of the literature to date include the use of small sample sizes and the restriction of investigation to primarily high functioning males with autism.

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Deep Repetitive Transcranial Magnetic Stimulation Associated With Improved Social Functioning in a Young Woman With an Autism Spectrum Disorder

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Deep Repetitive Transcranial Magnetic Stimulation Associated With Improved Social Functioning in a Young Woman With an Autism Spectrum Disorder

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Functional brain correlates of social and nonsocial processes in autism spectrum disorders: an activation likelihood estimation meta-analysis

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Functional brain correlates of social and nonsocial processes in autism spectrum disorders: an activation likelihood estimation meta-analysis

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Background

Functional neuroimaging studies of autism spectrum disorders (ASD) have examined social and nonsocial paradigms, although rarely in the same study. Here, we provide an objective, unbiased survey of functional brain abnormalities in ASD, related to both social and nonsocial processing.

Methods

We conducted two separate voxel-wise activation likelihood estimation meta-analyses of 39 functional neuroimaging studies consisting of 24 studies examining social processes (e.g., theory of mind, face perception) and 15 studies examining …

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Transcranial direct current stimulation (tDCS) over right temporoparietal junction (rTPJ) for social cognition and social skills in adults with autism spectrum disorder (ASD).

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Transcranial direct current stimulation (tDCS) over right temporoparietal junction (rTPJ) for social cognition and social skills in adults with autism spectrum disorder (ASD).

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The idea that social motivation deficits play a central role in Autism Spectrum Disorders (ASD) has recently gained increased interest. This constitutes a shift in autism research, which has traditionally focused more intensely on cognitive impairments, such as theory-of-mind deficits or executive dysfunction, and has granted comparatively less attention to motivational factors. This review delineates the concept of social motivation and capitalizes on recent findings in several research areas to provide an integrated account of social motivation at the behavioral, biological and evolutionary levels. We conclude that ASD can be construed as an extreme case of diminished social motivation and, as such, provides a powerful model to understand humans’ intrinsic drive to seek acceptance and avoid rejection.

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Meta Analyse

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Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome.

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https://www.pubmed.de/gateway/nlm-pubmed/

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Context Understanding a speaker's communicative intent in everyday interactions is likely to draw on cues such as facial expression and tone of voice. Prior research has shown that individuals with autism spectrum disorders (ASD) show reduced activity in brain regions that respond selectively to the face and voice. However, there is also evidence that activity in key regions can be increased if task demands allow for explicit processing of emotion.

Objectives To examine the neural circuitry underlying impairments in interpreting communicative intentions in ASD using irony comprehension as a test case, and to determine whether explicit instructions to attend to facial expression and tone of voice will elicit more normative patterns of brain activity.

Design, Setting, and Participants Eighteen boys with ASD (aged 7-17 years, full-scale IQ >70) and 18 typically developing (TD) boys underwent functional magnetic resonance imaging at the Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles.

Main Outcome Measures Blood oxygenation level-dependent brain activity during the presentation of short scenarios involving irony. Behavioral performance (accuracy and response time) was also recorded.

Results Reduced activity in the medial prefrontal cortex and right superior temporal gyrus was observed in children with ASD relative to TD children during the perception of potentially ironic vs control scenarios. Importantly, a significant group × condition interaction in the medial prefrontal cortex showed that activity was modulated by explicit instructions to attend to facial expression and tone of voice only in the ASD group. Finally, medial prefrontal cortex activity was inversely related to symptom severity in children with ASD such that children with greater social impairment showed less activity in this region.

Conclusions Explicit instructions to attend to facial expression and tone of voice can elicit increased activity in the medial prefrontal cortex, part of a network important for understanding the intentions of others, in children with ASD. These findings suggest a strategy for future intervention research.

Impairments in social communication are core features of autism spectrum disorders (ASD). Even high-functioning individuals with ASD who have advanced formal language skills (ie, phonology, morphology, and syntax) are impaired in pragmatics (ie, the social use of language in context). Understanding the communicative intentions of others is particularly difficult for individuals with ASD when nonliteral language is used, as in the case of irony.

In everyday social interactions, appreciating irony is likely to require both attending to the speaker's facial expression and tone of voice and integrating the information gleaned from these cues with the context of the situation at hand. Typically developing (TD) children are sensitive to affect conveyed through the human face and voice from very early on. Individuals with ASD, however, do not show the same early preference for faces and voices and often have difficulty extracting the affect expressed through these cues. Accordingly, neuroimaging studies have found that individuals with ASD show reduced activity in brain regions that respond selectively to the face and voice. Specifically, children and adults with ASD typically exhibit hypoactivation of the lateral fusiform gyrus (FG), the so-called fusiform face area, when viewing faces and facial emotions. With regard to voice perception, adults with autism fail to show voice-selective activity in the superior temporal sulcus despite a normal response to nonvocal sounds. Other studies of higher-level abilities that build on face and voice perception, such as language and "theory of mind," have shown reduced activity in prefrontal regions, including the left inferior frontal gyrus and medial prefrontal cortex (MPFC).

Evidence is emerging, however, to suggest that individuals with ASD can show more typical levels of neural activity in regions important for processing facial and vocal emotions if task demands allow for more cognitive or explicit processing. In a prior functional magnetic resonance imaging study, we asked children and adolescents with ASD to perform 2 tasks. In the matching task, participants selected 1 of 2 facial expressions to match the emotion shown in a target face. In the labeling task, they picked 1 of 2 words to describe the target expression. The ASD group showed reduced activity in the FG relative to TD controls during the more automatic matching task but not during the more cognitive or explicit labeling task. Similarly, Critchley et al observed hypoactivation of the amygdala when adults with autism labeled the gender of emotional faces (implicit condition) but comparable activity when labeling the emotion in the same faces (explicit condition). In the domain of language, children with ASD activated right frontotemporal regions typically associated with prosodic processing when attention to intonational cues was integral to the task. However, when automatic processing of prosody was required, individuals with ASD showed abnormal electrophysiological responses relative to controls.

Thus, there is some evidence to indicate that individuals with ASD may engage more normative neural networks when task demands require the explicit processing of emotion. However, in previous studies, facial and prosodic cues were presented in isolation. Little is known about the use of these cues in interpreting the communicative intent of others. We recently examined the role of prosody in understanding irony and found that individuals with ASD did activate regions recruited by TD controls when task demands required them to rely on the strong intonational cues provided. However, understanding the mental state of a speaker in a conversational setting typically also involves drawing on the important information conveyed through facial expression. As the number and complexity of available cues increases, children with ASD have been observed to make more errors in social perception, perhaps due to deficits in attention. Indeed, individuals with autism have demonstrated abnormal visual fixation patterns when viewing social scenes.

The goals of this study were thus 2-fold. First, we sought to examine the neural correlates of inferring the communicative intent behind a potentially ironic remark in children with ASD using a naturalistic context where facial, prosodic, and contextual cues were available. Second, and perhaps most importantly, we examined whether explicit instructions to attend to facial expression and tone of voice would elicit more normative activation patterns in children and adolescents with ASD.

Based on the results of a recent study using the same paradigm with TD children and adults, we expected scenarios involving irony detection to elicit greater activity in the MPFC and superior temporal gyrus (STG) than scenarios containing only literal utterances in TD children. Given behavioral research indicating that individuals with ASD are more likely than controls to interpret an ironic utterance literally, we expected less selective activity for potentially ironic scenarios compared with unambiguous scenarios in the ASD group. We further predicted that explicit directions to attend to important social cues would yield increased activity in regions important for processing emotion or intent in the ASD group. In contrast, the TD group should exhibit high levels of activity in these networks regardless of task instructions. Based on previous research described earlier, candidate regions for showing the predicted group × condition interaction include the MPFC, FG, amygdala, and frontotemporal networks.

The ASD group comprised 18 right-handed boys with a mean (SD) chronological age of 12.5 (3.0) years (range, 7-17 years) and a mean (SD) receptive language age of 13.4 (4.9) years (range, 7-22 years) measured by the Peabody Picture Vocabulary Test, third edition. Participants were recruited through the Autism Evaluation Clinic at the University of California, Los Angeles and flyers posted at regional centers throughout Los Angeles. A diagnosis of ASD was established using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised and supported by expert clinical opinion following DSM-IV criteria. We used the Social Responsiveness Scale to evaluate the severity of social impairment, although this information was not obtained for 3 participants. All of the subjects had fluent language skills (based on parental report and direct observation during the Autism Diagnostic Observation Schedule) and a full-scale IQ higher than 70 based on the Wechsler Abbreviated Scale of Intelligence, which has recently been shown to have excellent predictive accuracy for high-functioning individuals with autism, even for those with an atypical subtest profile. Participants had no reported history of neurological disorders (eg, epilepsy), psychiatric disorders other than autism (eg, schizophrenia, attention-deficit/hyperactivity disorder [ADHD]), or structural brain abnormalities.

For the comparison group, 18 right-handed TD boys (mean [SD] age, 11.8 [1.9] years; range, 9-15 years) were recruited from the community through flyers posted at the university and in the Los Angeles area. None had a history of head trauma or medical, neurological, or psychiatric disorders, including ADHD, according to parental report. The Social Communication Questionnaire was used to screen for the presence of autistic symptoms.

The ASD and TD groups did not differ significantly in chronological age, performance IQ, or full-scale IQ ( Table 1), although the mean verbal IQ (VIQ) was higher in TD children than in children with ASD ( t 1,34 = 2.9, P = .007, Cohen d>0.90; for all other comparisons, P>.10). Seven participants with ASD were receiving psychotropic medications (including selective serotonin reuptake inhibitors, stimulants, and new-generation neuroleptics). We performed all of the analyses without these subjects and found that the pattern of results remained the same. As such, we report the findings with the full sample of 18 subjects in each group. Participants and their parents gave written informed consent to participate in the study according to the guidelines of the institutional review board. Subjects were paid $25 per hour (up to $75) for participating.

Participants viewed cartoon drawings of children in conversational settings while listening to short vignettes ending with a potentially ironic remark ( Figure 1). Each scenario had an ironic version and a sincere version that shared the same neutral setup. The ironic ending contained an undesirable outcome and a final remark uttered in a clearly ironic tone of voice. The sincere ending had a positive outcome with a final comment made in a sincere, complimentary tone of voice. Following the sincere or ironic comment, participants decided whether the speaker really meant what he or she said. Yes or no judgments were indicated on a handheld response pad. Instructions were clear that a yes response should be given for a sincere comment that should be taken literally, whereas a no response should indicate an ironic remark that meant the opposite of what was said. Participants were shown examples of sincere and ironic scenarios not used during the scan and all answered correctly.

To verify that the final comments sounded sincere or ironic as intended, 12 adult volunteers listened to the remarks presented without the surrounding context and rated them on a scale of 1 to 7 (1 was the anchor for ironic and 7 for sincere or complimentary). Mean (SD) ratings were 1.4 (0.7) for ironic remarks and 6.6 (0.7) for sincere comments. Sincere and ironic versions of each scenario were matched in terms of syntactic structure, semantic complexity, and length. To examine the neural circuitry underlying the interpretation of irony per se, we also included a no irony condition comprising scenarios ending in straightforward, unambiguous remarks (eg, "Ashley and Zack are riding their bikes. When it starts to get dark out, Ashley says, 'Let's go home.'") These remarks were not easily interpretable in a nonliteral light and were made in a neutral tone of voice. All of the scenarios were tested previously in 12 normal adults and 12 TD children in a study of developmental change in the neural basis of interpreting communicative intent.

Four activation blocks were interspersed with 5 rest periods. The first 3 blocks each contained 6 different scenarios (3 ironic, 3 sincere) ending in a potentially ironic remark (eg, "Thanks a lot!"). Instructions given before the first block were simply to pay attention (neutral instructions condition). Before the second and third blocks, participants were told to pay attention to the facial expression (attend face condition) or to the tone of voice (attend prosody condition). We chose to put the neutral instructions condition first to be able to examine participants' natural response to potentially ironic scenarios without any carryover effect of instructions to attend to a specific cue. The order of instructions to attend to the face or voice in the second and third blocks was counterbalanced across subjects. The fourth and last activation block comprised 6 no irony control scenarios ending in an unambiguous statement (eg, "Please pass the crayons."). To avoid any specific item effects, scenarios were used equally often in each of the 3 irony conditions across subjects. Furthermore, participants saw only 1 version (sincere or ironic) of each scenario. There were 18 potentially ironic and 6 control scenarios in all; each lasted 15 seconds. Activation blocks were interspersed with 21-second rest periods for a total length of 7 minutes 45 seconds. Response times and accuracy were recorded during scanning.

Images were acquired on an Allegra 3-T scanner (Siemens Medical Systems, Malvern, Pa). A T2-weighted sagittal scout was used to prescribe the planes of the functional images and rule out structural abnormalities. For each subject, the functional data were 155 whole-brain axial volumes collected parallel to the anterior-posterior commissure line using a gradient-echo, echo-planar imaging sequence (repetition time, 3000 ms; echo time, 25 ms; 3-mm section thickness with 1-mm gap; 64 × 64 matrix size; field of view, 20 cm). A coplanar, high-resolution structural volume was also acquired using echo-planar imaging (repetition time, 5000 ms; echo time, 33 ms; 128 × 128 matrix size; field of view, 20 cm). No between-group differences were observed in mean head motion detected during the functional scan.

Imaging data were analyzed using SPM99 (Wellcome Department of Cognitive Neurology, London, England; http://www.fil.ion.ucl.ac.uk/spm). Functional images were realigned to correct for head motion, spatially transformed into a Talairach-compatible atlas for intersubject averaging, and smoothed (6-mm full-width half-maximum isotropic gaussian kernel) using Automated Image Registration. For each subject, condition effects were estimated according to the general linear model using a 6-second delayed boxcar reference function. Response time and accuracy scores collected during scanning were entered as regressors to ensure that differential activation observed between conditions or groups were not due to differences in task difficulty. The resulting contrast images were entered into group analyses using a random-effects model to allow for population-level inferences. Results were initially explored using liberal thresholds of P<.05 uncorrected for multiple comparisons for both magnitude and spatial extent. However, we consider significant and discuss only those activations that survived a more stringent extent threshold of P<.05 corrected for multiple comparisons at the cluster level (at least 115 contiguous voxels) with peaks of regional activity having a magnitude of t greater than 2.57 at the voxel level. For each group, 1-sample t tests were conducted to identify clusters of significant activity for each condition. Between-group differences were examined using 2-sample t tests within regions where significant activation was detected in either group across all conditions. This was accomplished by creating an image file for each group consisting of significant activity across all activation conditions vs rest and combining these images to create an inclusive mask.

Because verbal ability was higher in the TD group than in the ASD group, we used analyses of covariance to confirm that any between-group differences observed were not driven by differences in VIQ. For children with ASD, a multiple regression was conducted to identify regional activity associated with symptom severity controlling for VIQ. Based on previous research, regions implicated in reasoning about others' intentions (ie, MPFC, superior temporal sulcus, and temporal poles) and processing facial expression (ie, FG, amygdala, and superior temporal sulcus) and tone of voice (frontotemporal networks) were considered regions of interest. Within these regions for which we had a priori hypotheses, we used a small volume correction to test for significance using a sphere with an 8-mm radius centered at the local maxima (corresponding to a minimum of 55 contiguous voxels). To assess the robustness of our findings, effect sizes were computed for all of the significant between-group differences. All of the effect sizes exceeded the traditional benchmark qualifying large effect (ie, Cohen d>0.80).

No significant between-group differences were observed for response time or accuracy, defined as the proportion of correct responses divided by total responses, either overall or in any of the conditions ( Table 2) ( P>.10; data unavailable for 1 participant with ASD). However, across all irony conditions, children with ASD answered significantly fewer questions correctly than children in the TD group (ASD group: mean [SD] number of correct answers, 16.1 [1.0]; median, 16; TD group: mean [SD] number of correct answers, 17.1 [1.4]; median, 18; F 1,33 = 6.95, P = .01). This reflects the fact that children with ASD had a significantly greater number of no responses than TD children ( t ₃₃ = 2.71, P = .01). Although participants in the ASD group did not differ from controls in the accuracy of their judgments when they responded, the greater number of no responses may reflect more difficulty inferring the communicative intent of the speaker.

Accuracy was positively correlated with VIQ in both the ASD ( r ₁₅ = 0.51, P = .04) and TD ( r ₁₆ = 0.48, P = .04) groups. Because the number of correct responses differed significantly between the groups, we used regression analyses to probe for a relationship between this variable and brain activity and found no significant correlations in any of our regions of interest.

Functional magnetic resonance imaging results

To examine the networks specific to processing irony, we compared the activity summed across the 3 irony conditions (neutral instructions, attend to face, attend to prosody) with the no irony condition within each group. As expected, TD children showed significant activity bilaterally in the STG and in the dorsal and ventral MPFC. In contrast, despite showing similar activity in primary auditory and visual cortices during the no irony condition compared with TD children, participants with ASD did not recruit any brain regions during the irony conditions beyond those engaged during the no irony condition, where the speaker's intent was unambiguous.

A less selective neural response to ironic scenarios relative to nonironic scenarios in the ASD group was confirmed using a 2-sample t test. Activity in bilateral temporal regions and the MPFC was indeed greater in TD children than in children with ASD for the irony vs no irony comparison. An analysis of covariance confirmed that the TD group showed a stronger differential response to ironic scenarios in the MPFC and right STG, although between-group differences in the left temporal regions were no longer significant after controlling for VIQ ( Table 3).

Effect of Attentional Modulation

In the neutral instructions condition, interpreting a speaker's communicative intent was associated with activity in temporal and occipital cortices bilaterally in both groups. However, TD children also recruited prefrontal regions, including the MPFC and inferior frontal gyrus bilaterally. In contrast, participants with ASD did not show any frontal activity when instructions were neutral ( Table 4 and Figure 2A), even when the spatial extent threshold was lowered to P<.05 uncorrected for multiple comparisons.

As predicted, when explicitly instructed to attend to the facial expression or tone of voice, children with ASD did show significant activity in regions recruited by TD children when instructions were neutral, specifically in the MPFC and inferior frontal gyrus. Increases in activity in the inferior frontal gyrus were bilateral in the attend to face condition and restricted to the right hemisphere in the attend to prosody condition. Because instructions to attend to facial expression and tone of voice yielded very similar effects overall (both within and between groups), we present the data averaged across the 2 attend conditions compared with rest ( Table 4 and Figure 2 B).

Direct comparisons between groups confirmed that TD children did recruit the MPFC and STG more strongly than children with ASD during the neutral instructions condition. Greater cerebellar activity was also observed in the TD group relative to the ASD group. No regions were more strongly activated in children with ASD than in controls. For the attend conditions, TD children engaged the STG, cerebellum, and visual cortices more strongly than children with ASD. However, MPFC activity was no longer significantly different between the groups once specific instructions were provided. A group × condition interaction in the MPFC revealed that activity in this region differed significantly between the groups when specific vs neutral instructions were given. That is, whereas children with ASD showed significantly greater activity in the MPFC when told explicitly to attend to the facial expression or tone of voice than when instructions were neutral, children with TD showed the same amount of activity in this region regardless of instructions ( Table 5).

Analyses of covariance confirmed that the group × condition interaction in the MPFC was not due to between-group differences in verbal abilities. Likewise, the significant main effect of group (TD>ASD) in the STG was confirmed both when instructions were neutral and when they were specific to attend to the face or voice (relative to rest). However, after accounting for VIQ, between-group differences were no longer significant in the MPFC or cerebellum during the neutral instructions vs rest comparison or in the cerebellum or visual cortex during the attend to face or prosody vs rest comparison.

Correlations With Social Responsiveness

To relate brain activity to autistic symptoms, we conducted a multiple regression analysis in the ASD group. Controlling for VIQ, a significant negative correlation was found across all irony conditions between activity in the MPFC and social impairment as assessed by the Social Responsiveness Scale. That is, participants with a higher level of social functioning showed greater MPFC activity when attempting to infer a speaker's communicative intent ( Figure 3). Activity in the posterior middle temporal gyrus (Brodmann area 37) was also negatively correlated with the degree of social impairment.

We found significant differences in brain activity in children and adolescents with ASD compared with TD controls during the interpretation of a speaker's communicative intent. First, as compared with TD children, children with ASD exhibited a less selective response to potentially ironic scenarios relative to unambiguous scenarios as indicated by reduced activity in the MPFC and right STG. Second, a significant group × condition interaction in the MPFC showed that regional activity was modulated by explicit instructions to attend to facial expression and tone of voice only in children with ASD. However, regardless of instructions, less activity was observed in the STG bilaterally in children with ASD relative to TD children during the irony conditions compared with rest. Finally, MPFC activity was inversely related to symptom severity in the ASD group such that greater social competence was associated with greater activity in the MPFC across all irony conditions. Importantly, these differences were significant after controlling for VIQ.

A less selective neural response to ironic scenarios relative to straightforward scenarios in children with ASD coheres with behavioral evidence that these individuals often mistakenly attribute a literal meaning to ironic utterances. Previous research suggests that the MPFC is important for understanding others' mental states and that right-hemisphere temporal regions are engaged when coherence seeking is required. Selective activity in these regions in TD children for ironic scenarios likely reflects a greater need to integrate facial, prosodic, and contextual cues to infer the speaker's intent when the literal meaning of a remark conflicts with other available information. Reduced differential activity in this network in children with ASD may indicate less integrative reasoning about intent. Several other studies have also observed abnormalities in MPFC activity in individuals with ASD using a variety of tasks, including theory of mind and semantic processing. The one region where the ASD group showed greater selective activity than the TD group for ironic vs control scenarios was the angular gyrus, known to play an important role in semantic processing. Greater activity in the right angular gyrus in children with ASD than in controls could reflect more reliance on semantic processing at the word or sentence level, perhaps at the expense of integrative processing. However, once VIQ was taken into account, between-group differences in this region were no longer significant. This suggests that increased activity in the ASD group may reflect impaired verbal abilities rather than a true difference in semantic representation.

Perhaps most interesting is the finding that for children with ASD, explicit instructions to attend to facial expression or tone of voice elicited significantly greater activity in the MPFC than neutral instructions simply to pay attention. In contrast, TD children showed significant MPFC activity irrespective of instructions, consistent with evidence that this region is normally recruited automatically when processing communicative intentions. Our findings extend previous work suggesting that attention to crucial aspects of social stimuli can yield increased activity in regions that typically respond preferentially to such stimuli. Hadjikhani et al observed comparable levels of FG activity in individuals with ASD and controls when faces were presented with a red fixation cross at approximately eye level. Similarly, Dalton et al found that in individuals with ASD, FG activity increased with time spent looking at the eyes. With respect to understanding others' intentions, we recently found that children with ASD engaged neurocircuitry similar to that of TD controls when task demands implicitly required attention to prosodic or contextual cues to detect ironic intent. However, in a natural communicative setting, relevant cues are not experimentally highlighted. Interpreting irony correctly is likely to involve selectively attending to crucial cues (eg, facial expression and tone of voice) in a dynamic environment and integrating this information to reason about mental states. Here, increased MPFC activity in the ASD group following explicit instructions to attend to facial expression and tone of voice may reflect more reasoning about a speaker's communicative intent afforded by increased attention to these important cues. The significant association between MPFC activity during irony conditions and social competence in the ASD group suggests that recruitment of this region when inferring communicative intent is indicative of greater success in real-world social situations.

Regardless of task instructions, reduced activity was observed in the STG bilaterally in the ASD group relative to controls. Previous research has demonstrated that the superior temporal sulcus or STG plays a role in polymodal sensory integration and shows a greater response to congruent audiovisual stimuli than to either auditory or visual stimuli alone. Reduced STG activity during irony conditions in children with ASD could reflect difficulty detecting the correspondence between facial expression and tone of voice. This notion is consistent with behavioral studies suggesting that children with autism are impaired in matching facial and vocal affect.

To our knowledge, this study is the first to demonstrate that explicit instructions to attend to important social stimuli can elicit greater activity in the MPFC, a region normally recruited automatically while attempting to infer the communicative intent of another person. Along with other work, our results suggest that previous reports of hypoactivation in regions supporting the processing of socially relevant information may result from a primary impairment in social interest rather than a fundamental deficit in neural functioning. A lack of attention to faces, voices, and other social stimuli may impair the development of expertise in perceiving and using social cues as well as the automatic engagement of relevant neural circuitry.

The finding that specific instructions to attend to important social cues resulted in a normalization of MPFC activity in children and adolescents with ASD suggests a strategy for intervention. Adolphs et al recently showed that explicitly instructing a patient with bilateral amygdala damage to look at the eyes enabled normal recognition of fearful expressions. Similarly, our findings suggest that instructing individuals with ASD to attend to faces and voices may facilitate the extraction of information necessary for interpreting others' communicative intentions. An approach that combines instruction to use top-down cognitive strategies with perceptual training and reinforcement to facilitate bottom-up attentional processes could capitalize on cognitive strengths while addressing weaknesses in automatic mechanisms. Attentional training in different contexts should result in greater recruitment of the MPFC, perhaps enabling more efficient integration of socially relevant cues. In turn, this may lead to greater success in understanding others' intentions in everyday interactions. Attention to faces and voices may then become more rewarding and more automatic for individuals with ASD, ultimately leading to higher levels of social responsiveness.

This study has some limitations. First, instructions to attend to the face and voice did not result in enhanced behavioral performance in the ASD group. This is likely due to the simplicity of the scenarios, which had a visual depiction of the event outcome. Performance was excellent even when no attentional guidance was provided. Although prompting the ASD group to attend to facial and prosodic cues may lead to the recruitment of more normative neurocircuitry, behaviorally, more time and practice may be needed before a performance benefit is derived. Compensatory mechanisms developed over time by individuals with ASD are likely to be effective for simple scenarios similar to those used here but are unlikely to be adequate for inferring intent in more dynamic social situations. A second limitation is that the TD and ASD groups differed significantly in VIQ. This leaves open the possibility that our results could be influenced by differences in verbal abilities because task performance increased significantly with VIQ in both groups. However, across all irony conditions, neither VIQ nor accuracy was significantly related to activity in the MPFC, the main site of differences, in either group. A third limitation concerns the possible comorbidity of ASD and ADHD. Although we excluded individuals with a concurrent ADHD diagnosis, some participants were receiving medication, including stimulants. Given that excluding individuals receiving medication did not significantly alter the results and that impairment in theory of mind has not been associated with ADHD, we feel it is unlikely that comorbid ADHD significantly impacted our findings. A fourth limitation is that the length of the scenarios in our activation paradigm precluded the use of an event-related design, which would have allowed us to tease apart the neural response to ironic vs sincere scenarios. This compromise was made in the framework of examining the neural processes involved in interpreting communicative intent as a whole rather than assuming that inferring irony and inferring sincerity are independent functional processes. Finally, the age of our participants varied considerably. Although chronological age was not significantly associated with activity in regions where between-group differences were observed, future research should explore developmental changes in the neural networks supporting the interpretation of communicative intent in ASD.

Correspondence: A. Ting Wang, PhD, Seaver and New York Autism Center of Excellence, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, New York, NY 10029-6574 ( ting.wang@mssm.edu).

Submitted for Publication: May 18, 2006; final revision received September 21, 2006; accepted October 12, 2006.

Financial Disclosure: None reported.

Funding/Support: This study was supported in part by grant P01 HD035470 from the National Institute of Child Health and Human Development, grant R03 DC005159 from the National Institute on Deafness and Other Communication Disorders, and grants from the National Alliance for Autism Research, the Cure Autism Now Foundation, and the University of California, Davis MIND Institute.

Role of the Sponsor: The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the sponsors.

Previous Presentation: This work was presented in part at the International Meeting for Autism Research; May 6, 2005; Boston, Mass.

Acknowledgment: We thank the Brain Mapping Medical Research Organization, Brain Mapping Support Foundation, Pierson-Lovelace Foundation, Ahmanson Foundation, William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation, Tamkin Foundation, Jennifer Jones-Simon Foundation, Capital Group Companies Charitable Foundation, Robson Family, and Northstar Fund for their generous support. The project described was supported in part by grants RR12169, RR13642, and RR00865 from the National Center for Research Resources, a component of the National Institutes of Health; its contents are solely the responsibility of the authors and do not necessarily represent the official views of National Center for Research Resources or the National Institutes of Health.

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Context Understanding a speaker's communicative intent in everyday interactions is likely to draw on cues such as facial expression and tone of voice. Prior research has shown that individuals with autism spectrum disorders (ASD) show reduced activity in brain regions that respond selectively...

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Literaturrecherche bei PubMed zu Stimulationsstudien, die die Ergebnisse des diskutierten Artikels quasi anwenden. Wird die soziale Kognition besser, wenn man den medialen präfrontalen Kortex stimuliert?
--> Weitere Areale, die in der Studie von Bedeutung waren: inferiorer frontaler Gyrus, superiorer temporaler Gyrus, Cerebellum, visueller Kortex