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When Lady Macbeth said this in her speech, Macbeth is taken aback by her evil plans.

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Macbeth was shocked when the first part of the witches prophecy came true.

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Once Macbeth realized he could become king if the king was killed, he began his plots

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After the witches told him that he will be king he wanted that power and his ambition will drive him until he does become royalty

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Macbeth is covering up how he is the real murder of King Duncan.

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This shows that Macbeth is not content with being the Thane of Cawdor.

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Macbeth says he feels guilty about killing the king, but later on he kills both of his servants. His guilt doesn't affect him and he keeps doing bad things.

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This is Macbeth's reaction when Lady Macbeth says she wishes she could be a man to become king

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Macbeth kills his king and acts like life now has no meaning to him to avoid suspicion.

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Duncan died before he could see the results of the war.