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Source of Details- Article published in ACS Applied Bio Materials

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Source of Details- Article published in ACS Applied Bio Materials

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“Flexible Microneedle Array Patch for Chronic Wound Oxygenation and Biofilm Eradication” by Ian Woodhouse, Sina Nejati, Vidhya Selvamani, Hongjie Jiang, Shirisha Chittiboyina, Jesse Grant, Zeynep Mutlu, Jose Waimin, Nader S. Abutaleb, Mohamed N. Seleem, and Rahim Rahimi

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15 June 2021

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Chronic or non-healing wounds is a profound issue individuals encounter worldwide. Annually throughout the United States, statistics show that over 6 million people suffer from delayed wound healing (Woodhouse et al 2021). Patients experience pain and discomfort that can debilitate their normal functioning. These healthcare cases leave a significant burden on family and caregivers as well. Delayed wound healing can often result in an infection that can lead to sepsis or amputation. Scientists at Purdue University created a microneedle patch that can deliver oxygen and bactericidal agents to chronic wounds to facilitate healing. This noninvasive technology is designed to deliver oxygen by releasing calcium peroxide into the wound. This technology has been tested and has been proven to be beneficial in promoting tissue oxygenation.

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Video of Microneedle Oxygenation Process 

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Video of Microneedle Oxygenation Process 

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Flexible microneedles for treatment of wound biofilm infections

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This illustration shows an infected wound that has a bacterial biofilm layer. It also shows the oxygenation process of the microneedle patch.

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* Noninvasive technology- Painless
* Flexible device
* Kills bacteria by delivering oxygen to infected wounds
* Bactericidal properties
* High levels of cytocompatibility
* Treat antibiotic resistant biofilms

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* Minimal testing- only in porcine tissue samples
* Safety concerns surrounding cell death

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My most dominate five strengths from Clifton Strength Finders include: relator, learner, achiever, belief, and input. As a leader for the evaluation team, I plan to utilize all five of my strengths to inspire and motivate our team to accomplish our goal in cohesiveness. I chose 5 participants of whom I believe encompass characteristics and abilities that will be beneficial to our team as a whole.

Team:

Angelica- Her skills are essential to my team because she possess analytical (strategic thinking) as her most dominate strength. She has the ability to be proactive in challenging circumstances, and analyze information for proper implementation.

Carter- His most dominate strength is communication. Carter is great for my team because he posses the skill to communicate thoughts, plans, and goals precisely. He would also excel in presenting our groups overall proposal.

Fernando- His most dominate strength is Focus. Fernando skills are essential because he will help facilitate execution of our goals. His skills are also necessary in order to meet critical deadlines and complete critical task.

Mathew- Mathew’s most dominate strength is maximize. His skills can facilitate each group members attributes and potential for the team’s well-being. This will allow for optimal results for our team.

Rachel- Her most dominate strength is restorative. Her skills are essential because she is a problem solver. She has the ability to adapt or resolve challenging issues.

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As a geriatric nurse, I have observed delayed wound healing on numerous occasions. Whether from preexisting medical conditions such as diabetes or vascular disease these wounds are challenging to heal and treat. I believe that further research and testing needs to be conducted regarding this innovation; however, it does offer beneficial affects. This technology is dire due to the rise of antibiotic resistant infections. The microneedle patch is essential research that can advance medicine by promoting improvements in wound care.

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Woodhouse, I., Nejati, S., Selvamani, V., Jiang, H., Chittiboyina, S., Grant, J., Mutlu, Z., Waimin, J., Abutaleb, N. S., Seleem, M. N., & Rahimi, R. (2021) Flexible Microneedle Array Patch for Chronic Wound Oxygenation and Biofilm Eradication. ACS Publications, 4, 7, 5405–5415. https://doi.org/10.1021/acsabm.1c00087