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The store will not work correctly in the case when cookies are disabled. JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser. The products sold by Blue Sky Peptide are intended for laboratory research purposes only.

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Epithalon peptide is a synthetic peptide that mimics the naturally occurring protein epithalamin. Comprising just four amino acids-alanine, glutamic acid, asparagine, and glycine-Epithalon (also known as epitalon) has a molecular mass of 390 g/mol. This peptide is produced by the pineal gland in the brain and plays a vital role in regulating circadian rhythms and melatonin secretion. ¹
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Research on Epithalon has shown its various functions in animal models, including:

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Known as the AEDG peptide (named after its constituent amino acids), Epithalon has been investigated for its ability to upregulate telomerase, which contributes to anti-aging and anti-tumorigenic effects. ²
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In vitro studies have indicated that Epithalon can extend the lifespan of human fibroblast cell lines by allowing them to surpass the Hayflick limit, the point at which cells enter senescence. One study reported that Epithalon-treated cells could undergo over 44 passages, compared to just 34 passages for control cells. ³ Additionally, in vivo studies on mouse models of aging have shown that Epithalon treatment reduces chromosomal abnormalities in both wild-type and accelerated-aging mice. ⁴

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Product Information
Epithalon is supplied as a lyophilized white powder in 10 mg vials.
Important Notice
This peptide is intended for in vitro laboratory research only. It is not approved for human or veterinary use.
References

1. Khavinson V, Diomede F, Mironova E, Linkova N, et al. AEGD Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020 Feb;25(3):609.

2. Khavinson V. Peptides and Ageing. Neuro Endocrinol Lett. 2022;23 Suppl 3:11-144.

3. Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.

4. Khavinson VK, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cells. Bull Exp Biol Med. 2004 May;137(5):503-6.

5. Rosenfeld SV, Togo EF, Mikheev VS, Popovich IG, et al. Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice. Bull Exp Biol Med. 2002 Mar;133(3):274-6.

6. Kozina LS, Arutjunyan AV, Khavinson VK. Antioxidant properties of geroprotective peptides of the pineal gland. Arch Gerontol Geriatr. 2007;44 Suppl 1:213-6.

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IGF-1 LR3 is a synthetic peptide developed exclusively for in vitro laboratory research. Structurally similar to human insulin-like growth factor 1 (IGF-1), IGF-1 LR3 features specific modifications that enhance its bioavailability and extend its activity for research purposes. This variant has an extended peptide sequence (L) and replaces glutamic acid with arginine at the third position (R3), adding 13 amino acids to the N-terminus for a total of 83 amino acids compared to the 70 amino acids in standard IGF-1. ¹ These adjustments extend its half-life to 20-30 hours and increase potency by approximately threefold, making it an ideal choice for in vitro studies on cellular and metabolic mechanisms. 2,3

The enhanced potency of IGF-1 LR3 results from reduced binding to insulin-like growth factor-binding proteins (IGFBPs), which increases its biological activity in research settings. 1,2 Like insulin, IGF-1 LR3 binds to the IGFR1 receptor, promoting cell growth and muscle fiber differentiation in cultured cell lines and other in vitro models. 4,5 This peptide is widely used in laboratory studies to explore IGF-1 receptor interactions, cellular growth mechanisms, and protein synthesis pathways.

IGF-1 LR3 has shown potential across various in vitro research models, with notable applications including:

Cardiac Growth: In cell cultures and organoid models, IGF-1 LR3 has been used to study cardiomyocyte proliferation and vascular growth, mimicking cellular mechanisms relevant to cardiovascular development.⁶

Cancer Cachexia: Studies in controlled laboratory environments indicate that IGF-1 LR3 can activate the PI3K/AKT pathway to promote protein synthesis and prevent muscle atrophy, offering insights into metabolic support against muscle wasting.⁵

Important Compliance Notice: IGF-1 LR3 is intended strictly for in vitro laboratory research only and is not approved for human, therapeutic, diagnostic, or veterinary use. Any application outside controlled research environments is prohibited. Laboratory safety protocols should be followed when handling this peptide to ensure compliance with research standards.
References

1. Mohan S, Baylink DJ. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J Endocrinol. 2002 Oct;175(1):19-31.

2. Tomas FM, et al. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochem J. 1992 Feb;282(Pt 1):91-97.

3. von der Thusen J, et al. IGF-1 stabilizes plaques in atherosclerosis by altering vascular smooth muscle cell phenotype. Am J Pathol. 2011 Feb;178(2):924-934.

4. Wrigley S, et al. Insulin-Like Growth Factor 1: At the crossroads of brain development and aging. Front Cell Neurosci. 2017 Feb;11:14.

5. Lovolger S, et al. Inhibition of activin-like kinase ⅘ attenuates cancer cachexia-associated muscle wasting. Sci Rep. 2019;9:9826.

6. Jonker SS, et al. Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep. FASEB J. 2020 Aug;34(8):10041-10055.

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What Makes Hexarelin Different From The Other GHRPs?

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What Makes Hexarelin Different From The Other GHRPs?

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1. What is Hexarelin?

Hexarelin is a research peptide that’s under the classification of growth hormone releasing peptides, also known as GHRPs or GH secretagogues. Other forms of GHRPs include GHRP-6, GHRP-2 and Ipamorelin. Hexarelin is mainly used to provide pituitary gland stimulation, which causes a production of growth hormones. Like its GHRP counterparts, Hexarelin has a 2-step action plan that consists of suppressing Somatostatin actions, while increasing growth hormones (by amplifying the signal transduction pathway of growth hormone releasing hormones, also known as GHRH).

What Makes Hexarelin Different from the Other GHRPs?

When you look at the data, you’ll see that Hexarelin has characteristics that are unique from the other GHRPs mentioned above. In fact, it is the most potent of the growth hormone releasers. It out performs the other GH releasing peptide when you view the numbers on a mcg to mcg basis. There is also evidence (not yet proven) that there is higher rapidity rate of desensitization compared to the other research peptides, but the extent and the rate are still being studied. It’s recommended to researchers that they discontinue using Hexarelin within 2 weeks of starting use on test subjects. Going past this point may cause the GH to have an insignificant spike, due to the enhanced desensitization. However, there is a study that goes against this theory.

Study Done on the Rate of Desensitization of Hexarelin

Scientific research on animal test subjects were used in a study to determine the rate of desensitization of Hexarelin when it’s administered daily. Blood work from the animal test subjects were taken at the end of the week on weeks 1, 2, 4 and 16. The blood was then evaluated and conclusions were met that Hexarelin showed little difference in desensitization after one week and four weeks of administration. The doses included 1mg/kg and 2mg/kg daily. After the 16 week mark, the amount of growth hormone released was blunted.

What is Hexarelin Used for?

When Hexarelin was injected into animal test subjects, it has shown to have effects that include increased size of muscle fibers, neural protection, increased strength, new muscle fiber growth, joint rejuvenation, joint protection and joint healing. It is also believed to reduce the amount of fatty tissue, helping the test subject to lose fat. The growth is only due to the increase in hormones – it doesn’t boost appetite or quicken gastric emptying.

Results of Hexarelin in Test Subjects

The animal test subjects that used Hexarelin saw growth in muscle size due to the new muscle cell creation. Some even witnessed a more youthful appearance. It’s also shown to have quick healing for injuries. In some instances, cardiac benefits were seen. This peptide was used on some animal test subjects that have an inability to naturally produce their own growth hormones or who are seeking to look younger. Hexarelin is known to improve the elasticity of the skin. Overweight and athletic animal test subjects were also used and good results were achieved. Overall, it assists with fat reduction, injury healing and prevention, skin elasticity and muscle building.

Disclaimer: It’s important to note that Hexarelin is a peptide and is only to be used in clinical research studies. This should in no way be used for human consumption. Hexarelin should only be purchased for the sole purpose of vitro research being conducted in a laboratory setting, under strict guidelines. In the event that you or any of the researchers are exposed to this peptide, be sure to cleanse it immediately to prevent harm to the individual.

Hexarelin is a peptide that is still under research for the purposes of scientific studies.

Posted On: October 4 2014

2. What is Pramipexole Used For?

Pramipexole is a research liquid that has been used in studies on animal test subjects that suffer from Parkinson’s disease and other disorders that relate to the nervous system and exhibit difficulties moving, balancing and controlling muscles. Studies on animal test subjects have indicated that It may help to reduce the symptoms of Parkinson’s disease, such as stiffness, inability to balance, shaking body parts and slowed movements. Another study on animal test subjects indicated that Pramipexole showed improvements in restless legs syndrome, which is when the legs have a discomfort and there is a strong urge to move them. This constant leg movement mainly happens during the night, while lying down or sitting. You’ll find this research liquid under the classification of dopamine agonists. Studies have also shown on animal test subjects, it replaces dopamine, which is a natural substance located in the brain, and is needed to help animal test subjects control movement.

Side Effects of Pramipexole

Although Pramipexole is still being studied, there are side effects that have shown to be prevalent in some animal test subjects. One particular side effect is falling asleep during normal daily activities after being fully alert, such as while eating, moving around, or getting clean. Studies on animal test subjects have concluded It is not recommended that any type of strenuous activity come after exposure to this research liquid.

Studies indicate that intense urges may also arise, such as increased desire to have sex, eat odd things, or any other urges that aren’t normally present. The animal test subjects who shown to have restless leg syndrome sometimes have symptoms that grow worse or begin to witness restless symptoms in their arms and hands. In some instances, it may even cause hallucinations, but this is mainly amongst the elderly animal test subjects.

Here is a list of the other side effects that have been associated with Pramipexole studies:

Nausea, weakness, sweating, fainting or light-headedness

Muscle tenderness, pain or weakness, along with a fever or flu-like symptoms and urine that is dark-colored

Pain in the chest, coughing up mucus that is pink or white, and wheezing

Shortness of breath, rapid weight gain, swelling

Tremors in the eyes, tongue, lips, legs, face, or arms

Feeling weak or tired, appetite loss, or rapid weight loss

Blurred vision

Impotence, loss desire to have sex

Amnesia, problems thinking, insomnia, unusual dreams

Other Uses of Pramipexole

Other than being used for restless leg syndrome and Parkinson’s disease, there have also been studies conducted on animal test subjects who suffer from bipolar depression and unipolar depression. In the study for bipolar depression, twenty-one animal test subjects were given Pramipexole and it showed to be highly effective as treatment. The dosage was three times daily at 0.125 mg, and then was increased by 0.125 mg three times daily until 4.5 mg daily doses were reached. This is when the animal test subjects showed satisfactory responses to the research liquid or weren’t able to abide the side effects. The unipolar depression study also carried a controlled study and the results were efficacious in treating the condition.

More research studies are being done with Pramipexole for other health problems, like cluster headaches, which is a reoccurring severe headache that appears on one side of the head, usually near the eye. It has also been used on animal test subjects who have sexual dysfunction due to taking selective serotonin reuptake inhibitor antidepressants, also known as SSRIs. Currently, this research liquid is being studied to determine if it can successfully treat clinical depression and fibromyalgia.

Disclaimer: Pramipexole is a research liquid that should not be consumed by people. It should only be purchased for the purpose of conducting studies. Research projects should be performed in a lab setting using protective gear. Strict laboratory guidelines should be adhered to while testing this research liquid on subjects. It is also recommended that you immediately rinse the research liquid off of your skin if exposed to it.

Posted On: October 2 2014

3. What is AICAR Ribonuccleotide?

In scientific terms, AICAR Ribonuccleotide, or AICAR, is an analog of AMP. Studies have indicated it is able to stimulate AMP-dependent proteins kinase activity in animal test subjects. Because of this, it is being researched on animal test subjects in scientific studies to determine whether it can help treat and protect against cardiac ischemic injury. This is a condition that can lead to myocardial infarction. What causes this health problem is a lack of oxygen and flow of blood to the myocardium. It wasn’t until the 1980s, when the peptide was first researched on animal test subjects as a way to assist the heart with getting blood while having surgery. Research also shows that it could potentially treat other illnesses like diabetes, since it can boost the metabolic activity of tissues by changing the muscles’ physical composition in animal test subject studies.

Medical Use of AICAR Ribonuccleotide

AICAR Ribonuccleotide has shown it regulates various intracellular systems in animal test subjects, such as cellular glucose uptake, biogenesis of mitochondria, glucose transport 4 and B-Oxidation of fatty acids. When researched with animal test subjects, it has also shown to promote the storage of nutrients on a cellular level. In return, this enhances energy production.

AICAR has been used in animal test trials, which had results that indicate the research peptide's ability to regulate the functions of the heart. Scientifically put, the peptide is able to go into cardiac cells to inhibit enzyme production (i.e. adenosine kinase and adenosine deaminase). With the ability to block the enzymes, an increase in glucose (on a cellular level) and p38 mitogen-activated protein kinases A and B occurs in the skeletal muscle’s tissues. It also stops programmed cellular death (or apoptosis) from taking place.

When this peptide was studied on test subjects, the increase in the production of glucose and oxygen allowed the subject’s metabolism to reach a homeostasis level more efficiently.

Potential Benefits of AICAR

Due to the amount of testing that has been done, scientists have come up with theoretical benefits that can be linked to peptide. As mentioned above, one of the benefits happens to be AICAR’s ability to assist with cardiac ischemic injuries. Ischemic conditions can exist in many different areas of the animals test subject's body and in different forms, such as an embolism or thrombosis. In the case of cardiac ischemic injuries, it is directly related to the myocardium. Some cardiac ischemic episodes are asymptomatic, but can be linked to insufficient blood flow to the brain. This is called angina pectoris.

Research studies have shown that heart attacks too are caused by restriction of blood flow to the heart. Studies have also shown that AICAR Ribonuccleotide can help to treat animal test subjects heart muscle after a heart attack has occurred due to ischemic injury.

Side Effects Associated with AICAR

Through the tests that were performed on animal test subjects using AICAR, it has been proven that there are a couple of side effects associated with it. Since peptides deal mainly with the heart, it’s not surprising that the side effects lie here as well. Some of the side effects on animal test subjects include heart valve development defects and abnormal heart tissue growth.

Disclaimer: AICAR Ribonuccleotide should not be used or consumed by humans. The research conducted with this peptide was for experimentation and research purposes only. It should not be purchased for any other use. If purchased, AICAR should only be used under experimental circumstances that are under strict laboratory guidelines. Safety equipment should be worn and used when conducting experiments with AICAR. In the event that exposure occurs, immediate cleansing should take place to avoid harm to the individual.

It’s likely that studies for AIRCAR will continue over the next couple of decades. Doing so may one day bring about more ideas for treating and preventing ischemic injuries in animal test subjects.

Posted On: September 24 2014

4. How Does Letrozole Work?

Letrozole is the generic name of a currently tested research liquid called Femara. Scientific studies have been conducted on animal test subjects to determine whether this research liquid can be used to treat ovulation issues and unexplained infertility in different test subjects. Letrozole is a research liquid that is classified as an aromatase inhibitor. This research liquid has also been used in animal test subject studies for the treatment of cancer in breast tissue.

How Letrozole is used for Fertility

When animal test subjects are exposed to this research liquid, it has shown to inhibit the enzyme aromatase, which then causes estrogen levels to be suppressed. Studies on animal test subjects have shown to causes the brain and pituitary gland to release larger amounts of follicle stimulating hormones, or FSH. Animal test subjects that had polycystic ovary syndrome or anovulation (issues with ovulating), the FSH increase causes a mature follicle to develop within the ovary and cause egg ovulation. In the medical world, this is known as “induction of ovulation”.

Letrozole is also being studied on animal test subjects that are already able to ovulate, but are still having problems getting pregnant. When researched, Letrozole has shown to causes the development of multiple follicles, which results in multiple eggs being released. Scientific studies on animal test subjects indicate this may help to increase chances of animal test subjects from becoming pregnant during a natural menstrual cycle. The scientific term for the process of multiple eggs and follicles being produced is controlled ovarian hyper stimulation or superovulation.

Clomid Vs. Letrozole

Clomid, also known as clomiphene citrate, is another research liquid that is being studied with animal test subjects to help stimulate ovulation when it can’t be done naturally on their own. Some of the animal test subject concluded that Clomid didn’t work for researched Letrozole and received favorable results. The following results were determined:

Some of the test results who didn’t respond to Clomid had their ovulation induced when Letrozole was used.

Some of the animal test subjects that used Clomid and never got pregnant used Famara and conceived.

Unpleasant side effects results in some of the test subjects that used Clomid, making Famara more favorable for them.

Success Rate of Famara-Letrozole

The chances of test subjects becoming pregnant with Famara are pretty much the same as if they used Clomid. This all comes down to the age of the test subject, sperm quality and status of the fallopian tubes.

A higher success rate was found in test subjects that weren’t able to ovulate on their own. The following conditions improve the success rate of test subjects by 15% per month:

No other problems with fertility are found in the animal test subjects

The test subject is younger than half of their natural life cycle.

The lowest success rate was in animal test subjects that had unexplained infertility problems, but still ovulate on their own.

Other Uses for Letrozole

This research liquid has also been used on postmenopausal animal test subjects who have had surgery for hormone receptor-positive early breast cancer and advanced breast cancer. It has also been tested on subjects that have received five years of tamoxifen therapy. Research has been done on animal test subjects that are in menopause (natural or artificially induced) who have cancer that’s spread from their breast to other areas of the body, and have already had anti-estrogen therapy.

Letrozole is being tested in breast cancer animal test subjects because it inactivates an enzyme called aromatase, which prevents estrogen production. Estrogen is a known source for cancer cell growth.

Disclaimer: Letrozole is a research liquid that has been used for scientific research on animal test subjects for breast cancer and infertility. It is advised that you only purchase this product with the intention of vitro laboratory research and experimentation only. It is not intended for human use or consumption.

Posted On: September 22 2014

5. What is Selank Peptide

The heptapeptide Selank is one of the newer peptides undergoing extensive research of late. Researchers are trying to understand what the peptide does, how it interacts with different systems within the body of the different test subjects, and what the effects of this peptide are under different experimental circumstances. So far, researchers are learning quite a bit about how this peptide is nearly a synthetic reproduction of tuftsin, which most bodies create naturally within the spleen.

The Origins of Selank

Selank was originally developed out of the Institute of Molecular Genetics, at the Academy of Sciences in Russia. The current peptide sequence has been found to be Thr-Lys-Pro-Arg-Pro-Gly-Pro. This is showing researchers that it can inhibit the enzymes that are involved in the degradation of endogenous peptides as well as enkephalins. That is where the basis of the research began with selank.

The initial results were very promising when researchers began looking at the anxiolytic and nootropic effects of the peptide on the test subjects. This peptide began modulating Interleukin-6 expressions, and the brain-derived neurotropic factors in the test subjects of choice, in this case, rats.

What Researchers Are Discovering About Selank

So far, the most important discovery that researchers have made about selank is that it is showing great promise in reducing anxiety within the test subjects it has been tested on. There are no sedation effects being exhibited by the test subjects, but the anxiety and fear the animals were showing prior to exposure to selank is greatly reduced, or even gone in some cases. To make matters even better, this peptide has not shown any type of withdrawal symptoms after exposure to the peptide has stopped, and there are no signs of addictive tendencies being shown by any of the test subjects after repeated exposure to the peptide.

Another benefit that researchers have found is that the risk toxicity associated with exposure to selank is incredibly low. In fact, in numerous experiments, researchers exposed test subjects to much higher than normal doses, up to 500 times the standard dose, and found no ill effects. This makes the risk of any type of overdose with this peptide nearly negligible, allowing for researchers to be able to continuously perform experiments without having to worry about giving any of the test subjects a dose that is slightly too high, harming the animal.

This is helping researchers understand the importance in the regulation of both enkephalins and the endogenous peptides within the body when it comes to controlling anxiety. The more test subjects are exposed to this peptide, the more researchers are learning about the right levels each body needs to have in order to control anxiety. Through this discovery, researchers have also found that the more each test subject is exposed to selank, the stronger their immune system becomes, and the better their body is able to fight off illnesses.

DISCLAIMER: This peptide was solely created for research and experimental purposes, and should not be used for any purpose outside of experiments and research. Ingestion of selank is dangerous, and should not be attempted under any circumstances. Researchers using this peptide should wear all types of protective gear when using it for experiments, and should incidental contact occur, all attire should be thoroughly cleaned immediately.

Selank has the capability of teaching researchers a lot when it comes to how to boost an immune system and how to avoid anxiety. The more researchers can learn through test subject experimentation with selank, the more they will be able to learn about how the body works, and the better they will be able to set up future experiments to continue learning even more.

Posted On: September 6 2014

6. What is Sermorelin Used For

Sermorelin is one of the most commonly used peptides in growth research around. It is the smallest chain of workable amino acids with 29 acids in a row, which allows research to take place on how growth occurs in different types of exposure. The potential educational experiences that could come from sermorelin are quite lengthy due to the fact that this peptide can be synthesized so easily. The potential uses of this peptide are only now being discovered as research is just starting to put together what type of experiments this peptide works well with.

What Does Sermorelin Do?

Sermorelin currently has shown the ability to increase the test subject's natural levels of secretion of the pituitary gland's hormones for growth. This had given some test subjects the ability to start growing again after natural growth had stopped. This increase accompanied different doses, with the most effective being the dose that was given daily. The effect hit the test subjects very quickly, as it has a very short half-life of only 12 minutes on average.

So far it has shown growth in the cells that were exposed to the sermorelin within an experimental setting, as well as growth in the test subjects that were exposed to the peptide. There has been no evidence of any type of toxicity within the test subjects genes after exposure to sermorelin, but this has not been thoroughly tested. This peptide has also not been tested on pregnant or lactating test subjects, so the harm this may or may not cause is still unknown.

What Is Sermorelin Used For?

Currently, the most common use for sermorelin is that of research. Many companies are trying to understand what processes within the body turn on or turn off growth, and this peptide allows for this particular view to be studied. Since the synthesized peptide is so similar to the naturally occurring growth hormones, it allows researchers to get a very solid perspective on how different types of growth occur and how to stop that growth once it's started. The research environment allows for the researchers to view the growth on a cellular level under microscopes, which can help open up roads to new types of research in the future.

If a researcher is looking to do long-term research, the short life of Sermorelin is not going to work very well. However, for a researcher looking to do quick experiments that are easy to repeat to verify information and results, sermorelin is the ideal peptide for this purpose. It has the ability to initiate growth quickly, turn off quickly, and start the experiment over again in a matter of minutes, allowing researchers to view what repeated exposure may do to the test subjects.

DISCLAIMER: Sermorelin is created and distributed for research purposes only. It can be harmful if ingested by human beings, and should be avoided at all times. Should you desire to perform research with Sermorelin, all safety precautions should be taken prior to starting the experiment. Do not consume this peptide under any circumstances, and if accidental ingestion occurs, medical help should be sought out immediately.

Sermorelin has the potential to teach researchers quite a bit under the right circumstances. If the goal is to learn about growth on a fast, cellular level, Sermorelin should be the peptide of choice. The quick reaction of cells with the peptide makes the results found easy to replicate for verification purposes, and allows researchers to quickly and easily make their results known to the public. This short string of amino acids is quite similar to those found naturally within the body of test subjects, making it ideal for study and experimentation purposes.

Posted On: September 4 2014

7. What is Cabergoline

In the world of research liquids, Cabergoline is among one that is teaching scientists quite a bit. They have been studying the effects on numerous test subjects, but the ones that are showing the most promise in terms of research are rats. Researchers are able to see the results quickly, and change their experiments minimally to learn more about what the liquid itself is doing to the test subject's body. The benefits that Cabergoline could offer in terms of knowledge are growing with each new experiment that is being performed.

What Does Cabergoline Interact With?

First discovered in 1981, and patented in 1985, Cabergoline is a synthetic liquid that originated with researchers in Italy. This ergot derivative has shown impressive results in inhibiting prolactin cells on D2 receptors for dopamine. Researchers are regularly using this as a first line of defense when managing prolactins, because this research liquid seems to stick to more D2 receptors than other research liquids in the same family. However, it also sticks with other receptors, such as D3 and D4 receptors, and some of the 5-HT receptors.

What Are the Specifications of Cabergoline?

So far, researchers have discovered that Cabergoline has a half-life that is between 63 and 69 hours, allowing for researchers to perform long-term experiments and see how different test subjects and their cells react to Cabergoline exposure. Once the liquid starts to break down in preparation to exit the body, researchers have found the majority of the remnants to be excreted in the feces of the test subject, instead of the urine. There is very little information on whether or not this research liquid is safe during pregnancy, so those experiments are yet to come. However, rats have shown that it is crossing over into their milk, so it is not recommended to be experimented on during lactation. When it was used during lactation, it did show that the research liquid suppressed the milk production in the female rats, and has since been used to help treat false pregnancies in dogs so help dry up the milk supply.

What Side Effects Have Been Common with Cabergoline?

Researchers have found that most of the side effects that come along with exposure to Cabergoline are totally dependent on the dosage the test subject is exposed to. The more research liquid the rat was exposed to, the higher its chances of having one of these side effects. The most common side effects were nausea, dry mouth, low blood pressure, and constipation. Some of the less common side effects included disturbances in the test subject's sleeping cycles (either trouble sleeping or trouble staying awake), vertigo, irregular heartbeats, depression, and edema. Researchers also noticed that some of the test subjects also had increases in their levels of liver enzymes, but showed no adverse side effects of these increases.

Cabergoline is a very valuable liquid in terms of what it can teach researchers. They are able to see the differences that each dose can make on different cells over longer times than many other research liquids. The side effects that researchers are seeing with exposure to Cabergoline are minimal in comparison to the side effects that come with many of the ailments this research liquid is teaching them about; allowing them to see what damage is being done to the body by the ailments directly. This is helping researchers learn more about the body's response to these ailments, and could help uncover a way to treat them in the future for these test subjects.

DISCLAIMER: Cabergoline is not intended for human use or human consumption in any form. Exposure to this research liquid could cause harm, and should be avoided at all costs. These research liquids are for research purposes only, and should not be used for any other circumstance.

Posted On: September 2 2014

8. What is Clomiphene Citrate?

There are numerous liquids that are used for all types of research, and the same goes for Clomiphene Citrate. This common research liquid is used in many research campaigns when it comes to studying fertility issues within numerous species of test subjects. Each experiment that is being performed is leading to new discoveries when it comes to fertility, specifically ovulation and sperm count issues, and is helping scientists learn more about mammal reproductive systems.

What Is Clomiphene Citrate?

This research liquid is commonly used in the study of mammalian reproductive issues. It has shown promise in helping to correct issues for both male and female test subjects. The majority of test subjects exposed to Clomiphene Citrate with regular reproductive issues wound up pregnant, and the chances of miscarriage after exposure to Clomiphene Citrate did not increase in any of the mammals tested.

What Does Clomiphene Citrate Do?

When Clomiphene Citrate is used for research, it is commonly used to help resolve different types of reproductive issues. It has been shown through numerous types of research to boost low sperm counts and testosterone levels in male test subjects, plus it has been shown to increase chances of ovulation in female test subjects. This is helping researchers diagnose reproductive issues and learn what some of the causes of these issues could be. So far, researchers have learned a lot and helped to solve some of the more common reproductive mysteries.

Clomiphene Citrate has been used to treat test subjects that have issues such as infrequent or lack of ovulation, and has shown great successes in the female test subjects becoming pregnant. This is done by the research liquid stimulating the female reproductive system to produce and release one, or numerous, eggs. It has helped researchers learn what types of hormones each animal's body produces prior to and during ovulation, and studying what level those hormones need to get to and stay at to successfully maintain a pregnancy.

It has also been used to increase testosterone levels in male test subjects of different stages in life. It has been successfully used in juvenile test subjects through elderly test subjects, and shown success. This allows for an increased chance of pregnancy when the issues stood within the male part of the test subject couple. Male test subjects also showed increased energy, an increase in muscle mass, loss of fat on the body, and overall better emotional health when exposed to Clomiphene Citrate. The main benefit that researchers saw on the male test subjects is that it showed no interference in how the body maintained the proper balance of the testosterone, after the body got stimulated to make more. The body was still able to properly function, instead of having to risk having too much testosterone left over.

DISCLAIMER: Clomiphene Citrate is not intended for any type of human consumption. This research liquid is for research purposes only, and should not be used for any other purpose. Researchers using this research liquid should wear all protective clothing to minimize the chances of any incidental contact, and should any type of exposure occur, steps should be taken to cleanse the affected area immediately.

The research into Clomiphene Citrate has been going on for years, but there are still many things that it can teach scientists. The more that this research liquid is studied, the more researchers are learning when it comes to proper diagnosis and resolution to many mammalian reproductive issues. This peptide has the opportunity to break the reproduction system of mammals into easier to fix steps than ever before.

Posted On: August 14 2014

9. What you need to know about Follistatin

The activin-binding protein Follistatin, also known as FS, is a protein found within the tissues of most animals at the highest levels. There have been connections found between test subjects that had polycystic ovarian syndrome and those suffering infertility issues, as the peptide has shown to inhibit the release of standard hormones within the body. There have also been connections found between normal levels of FS in a body and the amount of muscle each test subject showed prior to any type of experimentation.

Follistatin Basics

Follistatin-344 is myostatin inhibitor polypeptide that consists of a single chain of 344 amino acids, allowing it to perform as an activin antagonist in many different types of research experiments. This peptide inhibits the release of hormones during ovarian follicle-stimulation. This has been shown during experiments to increase lean muscle mass while bypassing added fat in numerous different types of test subjects used. The test subjects that were exposed to FS showed great increases in muscle mass that did not decrease after the exposure to FS stopped. So far, the mammals that were used during these experiments have shown a permanent growth in muscle that has no signs of deterioration or damage to the body after the exposure.

The highest amounts of FS are naturally found within the ovary of female test subjects, followed closely by the skin. This peptide has a very strong role when it comes to proliferation at the cellular level, and has shown a large amount of differentiation at the cellular level as well. These two roles are incredibly important when it comes to the repair and rebuilding of cells, and has shown a lot of promise in experiments involving continuous exposure to new and diverse peptides.

How Will You Get Your Follistatin?

You will receive your FS in a powdered form, allowing you to easily dilute what you need for your specific research purposes. This freeze-dried powder is derived from E.coli but sterilized for research purposes. It can remain stable at a standard room temperature for approximately three weeks, but it is highly recommended that all FS forms, both powdered and aqueous, be stored below -18 degrees Centigrade. After freezing, the solution should be stored at 4 degrees Centigrade until used, or up to seven days, and if not used during that time frame, it should go back to the below -18 degrees Centigrade for continued safety and purity.

DISCLAIMER: Follistatin is not to be used for any type of ingestion by humans. This research peptide is only for experimentation, and should not be purchased or used with the intention of any other use. This item is only to be used during strict experiment circumstances under direct laboratory guidelines. Researchers should use any and all forms of safety equipment during each experiment. If exposure should occur, anything exposed should be cleansed immediately to avoid harm to the researcher.

Follistatin has shown researchers a lot about muscle mass, how different test subjects hold on to that muscle mass, and what each body does to try and gain more muscle mass. The experiments involving FS are just the beginning when it comes to learning about mammalian muscle mass, and much more has the potential to be learned over the next few decades with more research. The more animals that can be learned from now, the more scientists will learn with each new experiment in the future.

10. How Does Tadalafil Work?

Tadalafil is a research liquid that is marketed as a phosphodiesterase type 5 (PDE5) inhibitor. Researchers have been studying this peptide for many years to see what type of effects it has when exposed to different types of tissues and bodily systems from test subjects. This research liquid is showing great promise for researchers to further their understanding of how these types of inhibitors work. In order to understand how this type of inhibitor works, you need to understand the basics of Tadalafil.

Tadalafil Research Liquid

This research liquid was originally studied to see what kind of reaction it would have when exposed to different animals. Scientists guessed that Tadalafil would inhibit blood flow based on the chemical makeup (C22H19N3O4), but they had no idea where. At first, they saw little reaction, but then with a little deeper delving into how the animals were reacting, they noticed a correlation with the constriction of blood flow in and around the heart. This showed similar results to sildenafil, but had a much longer half life (over three times as long), allowing it to be used for longer experiments and give researchers more insight as to what was all happening with the body of the test subject, and tissue samples used during the research. This allowed researchers to also perform longer experiments that could fill in more of the blanks that researchers were looking for, without having to start each experiment over from scratch.

What Tadalafil Does When Exposed to Experimentation

Tadalafil has shown a lot of promise when used to control blood pressure in different types of test subjects. Many of the animals involved showed a lowering of blood pressure plus a better regulation of blood pressure under stressful situations than those exposed to the placebo. While the test subjects were being monitored for their blood pressure and heart rates, the researchers also noticed an increase in blood to the genitalia of male test subjects, often causing erections. While this was not ever an expected result from the research, it has helped researchers understand some of the bodily functions of the test subjects better than before their exposure to Tadalafil.

Tadalafil works by increasing the blood flow throughout certain regions of the body, such as the genitalia, and constricting the blood flow around the heart that is responsible for higher levels of blood pressure. When this research liquid works in tandem with a male test subject, it often shows signs of helping the heart better control the flow of blood during many levels of activity or stress, while still allowing increased blood flow to the penis, increasing the subject's ability to gain and sustain an erection.

DISCLAIMER: This research liquid was not created or ever intended for human consumption in any way. One should not risk any type of exposure to this liquid, and all safety precautions should be taken when having the chance of exposure in any form. If you plan on doing research you must ensure that you are wearing the proper safety gear before using this research liquid to reduce your risk of exposure. Under no circumstances should Tadalafil be ingested, as it can cause serious complications or health problems.

Tadalafil has been studied for over twenty years, and is still being studied with a lot of potential today. There are many different research liquid that offer similar knowledge to this PDE5 inhibitor, but none of them are as long-standing. That allows this research liquid to offer a unique opportunity to those who are researching it and its effects during experimentation. When studying the effects of Tadalafil, scientists have learned quite a bit, and still feel as though there is even more to learn.

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In scientific terms, AICAR Ribonuccleotide, or AICAR, is an analog of AMP. Studies have indicated it is able to stimulate AMP-dependent proteins kinase activity in animal test subjects. Because of this, it is being researched on animal test subjects in scientific studies to determine whether it can help treat and protect against cardiac ischemic injury. This is a condition that can lead to myocardial infarction. What causes this health problem is a lack of oxygen and flow of blood to the myocardium. It wasn't until the 1980s, when the peptide was first researched on animal test subjects as a way to assist the heart with getting blood while having surgery. Research also shows that it could potentially treat other illnesses like diabetes, since it can boost the metabolic activity of tissues by changing the muscles' physical composition in animal test subject studies.
Medical Use of AICAR Ribonuccleotide
AICAR Ribonuccleotide has shown it regulates various intracellular systems in animal test subjects, such as cellular glucose uptake, biogenesis of mitochondria, glucose transport 4 and B-Oxidation of fatty acids. When researched with animal test subjects, it has also shown to promote the storage of nutrients on a cellular level. In return, this enhances energy production.

AICAR has been used in animal test trials, which had results that indicate the research peptide's ability to regulate the functions of the heart. Scientifically put, the peptide is able to go into cardiac cells to inhibit enzyme production (i.e. adenosine kinase and adenosine deaminase). With the ability to block the enzymes, an increase in glucose (on a cellular level) and p38 mitogen-activated protein kinases A and B occurs in the skeletal muscle's tissues. It also stops programmed cellular death (or apoptosis) from taking place.

When this peptide was studied on test subjects, the increase in the production of glucose and oxygen allowed the subject's metabolism to reach a homeostasis level more efficiently.
Potential Benefits of AICAR
Due to the amount of testing that has been done, scientists have come up with theoretical benefits that can be linked to peptide. As mentioned above, one of the benefits happens to be AICAR's ability to assist with cardiac ischemic injuries. Ischemic conditions can exist in many different areas of the animals test subject's body and in different forms, such as an embolism or thrombosis. In the case of cardiac ischemic injuries, it is directly related to the myocardium. Some cardiac ischemic episodes are asymptomatic, but can be linked to insufficient blood flow to the brain. This is called angina pectoris.

Research studies have shown that heart attacks too are caused by restriction of blood flow to the heart. Studies have also shown that AICAR Ribonuccleotide can help to treat animal test subjects heart muscle after a heart attack has occurred due to ischemic injury.
Side Effects Associated with AICAR
Through the tests that were performed on animal test subjects using AICAR, it has been proven that there are a couple of side effects associated with it. Since peptides deal mainly with the heart, it's not surprising that the side effects lie here as well. Some of the side effects on animal test subjects include heart valve development defects and abnormal heart tissue growth.

Disclaimer: AICAR Ribonuccleotide should not be used or consumed by humans. The research conducted with this peptide was for experimentation and research purposes only. It should not be purchased for any other use. If purchased, AICAR should only be used under experimental circumstances that are under strict laboratory guidelines. Safety equipment should be worn and used when conducting experiments with AICAR. In the event that exposure occurs, immediate cleansing should take place to avoid harm to the individual.

It's likely that studies for AIRCAR will continue over the next couple of decades. Doing so may one day bring about more ideas for treating and preventing ischemic injuries in animal test subjects.

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In scientific terms, AICAR Ribonuccleotide, or AICAR, is an analog of AMP. Studies have indicated it is able to stimulate AMP-dependent proteins kinase activity in animal test subjects. Because of this, it is being researched on animal test subjects in scientific studies to determine whether it can help treat and protect against cardiac ischemic injury.

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Letrozole is the generic name of a currently tested research liquid called Femara. Scientific studies have been conducted on animal test subjects to determine whether this research liquid can be used to treat ovulation issues and unexplained infertility in different test subjects. Letrozole is a research liquid that is classified as an aromatase inhibitor. This research liquid has also been used in animal test subject studies for the treatment of cancer in breast tissue.
How Letrozole is used for Fertility
When animal test subjects are exposed to this research liquid, it has shown to inhibit the enzyme aromatase, which then causes estrogen levels to be suppressed. Studies on animal test subjects have shown to causes the brain and pituitary gland to release larger amounts of follicle stimulating hormones, or FSH. Animal test subjects that had polycystic ovary syndrome or anovulation (issues with ovulating), the FSH increase causes a mature follicle to develop within the ovary and cause egg ovulation. In the medical world, this is known as "induction of ovulation".

Letrozole is also being studied on animal test subjects that are already able to ovulate, but are still having problems getting pregnant. When researched, Letrozole has shown to causes the development of multiple follicles, which results in multiple eggs being released. Scientific studies on animal test subjects indicate this may help to increase chances of animal test subjects from becoming pregnant during a natural menstrual cycle. The scientific term for the process of multiple eggs and follicles being produced is controlled ovarian hyper stimulation or superovulation.
Clomid Vs. Letrozole
Clomid, also known as clomiphene citrate, is another research liquid that is being studied with animal test subjects to help stimulate ovulation when it can't be done naturally on their own. Some of the animal test subject concluded that Clomid didn't work for researched Letrozole and received favorable results. The following results were determined:

Some of the test results who didn't respond to Clomid had their ovulation induced when Letrozole was used.

Some of the animal test subjects that used Clomid and never got pregnant used Famara and conceived.

Unpleasant side effects results in some of the test subjects that used Clomid, making Famara more favorable for them.

Success Rate of Famara-Letrozole
The chances of test subjects becoming pregnant with Famara are pretty much the same as if they used Clomid. This all comes down to the age of the test subject, sperm quality and status of the fallopian tubes.

A higher success rate was found in test subjects that weren't able to ovulate on their own. The following conditions improve the success rate of test subjects by 15% per month:

No other problems with fertility are found in the animal test subjects

The test subject is younger than half of their natural life cycle.

The lowest success rate was in animal test subjects that had unexplained infertility problems, but still ovulate on their own.
Other Uses for Letrozole
This research liquid has also been used on postmenopausal animal test subjects who have had surgery for hormone receptor-positive early breast cancer and advanced breast cancer. It has also been tested on subjects that have received five years of tamoxifen therapy. Research has been done on animal test subjects that are in menopause (natural or artificially induced) who have cancer that's spread from their breast to other areas of the body, and have already had anti-estrogen therapy.

Letrozole is being tested in breast cancer animal test subjects because it inactivates an enzyme called aromatase, which prevents estrogen production. Estrogen is a known source for cancer cell growth.

Disclaimer: Letrozole is a research liquid that has been used for scientific research on animal test subjects for breast cancer and infertility. It is advised that you only purchase this product with the intention of vitro laboratory research and experimentation only. It is not intended for human use or consumption.

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Letrozole is the generic name of a currently tested research liquid called Femara. Scientific studies have been conducted on animal test subjects to determine whether this research liquid can be used to treat ovulation issues and unexplained infertility in different test subjects.

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What Researchers Are Discovering About Selank

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What Researchers Are Discovering About Selank

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The heptapeptide Selank is one of the newer peptides undergoing extensive research of late. Researchers are trying to understand what the peptide does, how it interacts with different systems within the body of the different test subjects, and what the effects of this peptide are under different experimental circumstances. So far, researchers are learning quite a bit about how this peptide is nearly a synthetic reproduction of tuftsin, which most bodies create naturally within the spleen.

The Origins of Selank

Selank was originally developed out of the Institute of Molecular Genetics, at the Academy of Sciences in Russia. The current peptide sequence has been found to be Thr-Lys-Pro-Arg-Pro-Gly-Pro. This is showing researchers that it can inhibit the enzymes that are involved in the degradation of endogenous peptides as well as enkephalins. That is where the basis of the research began with selank.

The initial results were very promising when researchers began looking at the anxiolytic and nootropic effects of the peptide on the test subjects. This peptide began modulating Interleukin-6 expressions, and the brain-derived neurotropic factors in the test subjects of choice, in this case, rats.

What Researchers Are Discovering About Selank

So far, the most important discovery that researchers have made about selank is that it is showing great promise in reducing anxiety within the test subjects it has been tested on. There are no sedation effects being exhibited by the test subjects, but the anxiety and fear the animals were showing prior to exposure to selank is greatly reduced, or even gone in some cases. To make matters even better, this peptide has not shown any type of withdrawal symptoms after exposure to the peptide has stopped, and there are no signs of addictive tendencies being shown by any of the test subjects after repeated exposure to the peptide.

Another benefit that researchers have found is that the risk toxicity associated with exposure to selank is incredibly low. In fact, in numerous experiments, researchers exposed test subjects to much higher than normal doses, up to 500 times the standard dose, and found no ill effects. This makes the risk of any type of overdose with this peptide nearly negligible, allowing for researchers to be able to continuously perform experiments without having to worry about giving any of the test subjects a dose that is slightly too high, harming the animal.

This is helping researchers understand the importance in the regulation of both enkephalins and the endogenous peptides within the body when it comes to controlling anxiety. The more test subjects are exposed to this peptide, the more researchers are learning about the right levels each body needs to have in order to control anxiety. Through this discovery, researchers have also found that the more each test subject is exposed to selank, the stronger their immune system becomes, and the better their body is able to fight off illnesses.

DISCLAIMER: This peptide was solely created for research and experimental purposes, and should not be used for any purpose outside of experiments and research. Ingestion of selank is dangerous, and should not be attempted under any circumstances. Researchers using this peptide should wear all types of protective gear when using it for experiments, and should incidental contact occur, all attire should be thoroughly cleaned immediately.

Selank has the capability of teaching researchers a lot when it comes to how to boost an immune system and how to avoid anxiety. The more researchers can learn through test subject experimentation with selank, the more they will be able to learn about how the body works, and the better they will be able to set up future experiments to continue learning even more.

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The heptapeptide Selank is one of the newer peptides undergoing extensive research of late. Researchers are trying to understand what the peptide does, how it interacts with different systems within the body of the different test subjects, and what the effects of this peptide are under different experimental circumstances.

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Sermorelin is one of the most commonly used peptides in growth research around. It is the smallest chain of workable amino acids with 29 acids in a row, which allows research to take place on how growth occurs in different types of exposure. The potential educational experiences that could come from sermorelin are quite lengthy due to the fact that this peptide can be synthesized so easily. The potential uses of this peptide are only now being discovered as research is just starting to put together what type of experiments this peptide works well with.

What Does Sermorelin Do?

Sermorelin currently has shown the ability to increase the test subject's natural levels of secretion of the pituitary gland's hormones for growth. This had given some test subjects the ability to start growing again after natural growth had stopped. This increase accompanied different doses, with the most effective being the dose that was given daily. The effect hit the test subjects very quickly, as it has a very short half-life of only 12 minutes on average.

So far it has shown growth in the cells that were exposed to the sermorelin within an experimental setting, as well as growth in the test subjects that were exposed to the peptide. There has been no evidence of any type of toxicity within the test subjects genes after exposure to sermorelin, but this has not been thoroughly tested. This peptide has also not been tested on pregnant or lactating test subjects, so the harm this may or may not cause is still unknown.

What Is Sermorelin Used For?

Currently, the most common use for sermorelin is that of research. Many companies are trying to understand what processes within the body turn on or turn off growth, and this peptide allows for this particular view to be studied. Since the synthesized peptide is so similar to the naturally occurring growth hormones, it allows researchers to get a very solid perspective on how different types of growth occur and how to stop that growth once it's started. The research environment allows for the researchers to view the growth on a cellular level under microscopes, which can help open up roads to new types of research in the future.

If a researcher is looking to do long-term research, the short life of Sermorelin is not going to work very well. However, for a researcher looking to do quick experiments that are easy to repeat to verify information and results, sermorelin is the ideal peptide for this purpose. It has the ability to initiate growth quickly, turn off quickly, and start the experiment over again in a matter of minutes, allowing researchers to view what repeated exposure may do to the test subjects.

DISCLAIMER: Sermorelin is created and distributed for research purposes only. It can be harmful if ingested by human beings, and should be avoided at all times. Should you desire to perform research with Sermorelin, all safety precautions should be taken prior to starting the experiment. Do not consume this peptide under any circumstances, and if accidental ingestion occurs, medical help should be sought out immediately.

Sermorelin has the potential to teach researchers quite a bit under the right circumstances. If the goal is to learn about growth on a fast, cellular level, Sermorelin should be the peptide of choice. The quick reaction of cells with the peptide makes the results found easy to replicate for verification purposes, and allows researchers to quickly and easily make their results known to the public. This short string of amino acids is quite similar to those found naturally within the body of test subjects, making it ideal for study and experimentation purposes.

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Sermorelin is one of the most commonly used peptides in growth research around. It is the smallest chain of workable amino acids with 29 acids in a row, which allows research to take place on how growth occurs in different types of exposure.

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Buy 1 Get 1 Free BPC 157 5mg :

Unit Size

5 mg/vial

Unit Quantity

1 vial

Purity (HPLC)

98.12%

Sequence

H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH

Molecular Formula

C62H98N16O22

Molecular Weight

1419.57

Net Weight

250.00mg

Appearance

lyophilized White Powder

Source

Chemical Synthesis

Storage

Lyophilized BPC 157 is Stable at room
Temperature for 90 days, however it is best to store
in a freezer below - 8c for any extended
period of time. After reconstitution BPC 157 should be
refrigerated at temperatures not to exceed 35 F.

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ACE-031 is a soluble form of the IIB subtype of the activin receptor type, also known as ActRIIB ¹. Therefore, it is thought to have a positive effect on muscle growth via the inhibition of myostatin and other proteins involved in the regulation of muscle mass 1,2. Some researchers conclude that ActRIIB is the receptor for myostatin, and that their complex mediates a pathway leading to the negative regulation of muscle mass ³. This may be substantiated by observations of significantly increased skeletal muscle in animals expressing mutant ActRIIB (i.e. ActRIIB to which myostatin could not bind) ⁴. Soluble ActRIIB is synthesized through the conjugation of an active domain of this receptor (e.g. the extracellular component) with another protein such as a fragment of a murine or human immunoglobulin ³. This peptide has demonstrated the ability to significantly enhance muscle mass and performance in adult, young and castrated male mice ². Another study demonstrated the ability of a two-week regimen of treatment with this soluble receptor to increase skeletal muscle in mice by as much as 60% ⁴.
ACE-031 and Androgen Deprivation
This peptide may counteract the effects of androgen deficiency ⁵. This condition involves reductions in the production or biological activity of male hormones such as testosterone, and may occur as a result of aging or hypogonadism. It is associated with reductions in bone density, muscle mass and adipose tissue regulation ⁵. An animal study treated both castrated and control mice with either soluble ActRIIB or an identical placebo. The soluble ActRIIB treatment resulted in significant increases in non-adipose tissue mass in both the control and castrated animals compared to changes associated with the placebo treatment ⁵. Soluble ActRIIB was also associated with significant changes in adiposity compared to placebo, but only in the castrated animals ⁵. The researchers also reported that treatment with the peptide also prevented steatohepatosis (the development of fatty liver disease), changed insulin levels and promoted bone density retention in castrated animals ⁵. Another study of the effects of soluble ActRIIB on 18-month-old, castrated and adult mice respectively also reported positive effects on bone density and a marker of bone growth ². Therefore, ACE-031 may help to prevent androgen deficiency, which is seen as a disease in mammals that requires treatment by some researchers ⁵.
ACE-031 and its Role in Muscle Growth
Soluble ActRIIB may significantly improve muscle mass and strength in animal studies, as outlined above. However, when researchers analyzed this effect in more detail, they found that the peptide had the most beneficial effects on muscle fiber types with reduced fatigue-resistance, compared to other more resistant types ². This may be related to the actions of myostatin, which have been shown to concentrate on one specific fiber type (i.e. type II) ⁶. Therefore, the positive effects of ACE-031 on muscle mass may be restricted to the acute, or relatively short-term. However, other research has shown that ACE-031 increases growth in multiple muscle fiber types indiscriminately ⁶. In addition, ACE-031 does not bind exclusively to myostatin, but to other similar proteins such as GDF11 and (as the receptor name suggests) activin ³. Therefore, its effects on muscle mass may extend beyond the simple antagonism of myostatin.
References:
1. Attie KM, Borgstein NG, Yang Y, et al. A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle & nerve.2013;47(3):416-423.

2. Chiu CS, Peekhaus N, Weber H, et al. Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents. The journals of gerontology. Series A, Biological sciences and medical sciences.2013;68(10):1181-1192.

3. Rahimov F, King OD, Warsing LC, et al. Gene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor. Physiological genomics.2011;43(8):398-407.

4. Lee SJ, McPherron AC. Regulation of myostatin activity and muscle growth. Proceedings of the National Academy of Sciences of the United States of America.2001;98(16):9306-9311.

5. Koncarevic A, Cornwall-Brady M, Pullen A, et al. A soluble activin receptor type IIb prevents the effects of androgen deprivation on body composition and bone health. Endocrinology.2010;151(9):4289-4300.

6. Cadena SM, Tomkinson KN, Monnell TE, et al. Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type. Journal of applied physiology (Bethesda, Md. : 1985).2010;109(3):635-642.

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ACE-031: Not Just a Myostatin Inhibitor(?)

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ACE-031 is a soluble form of the IIB subtype of the activin receptor type, also known as ActRIIB1. Therefore, it is thought to have a positive effect on muscle growth via the inhibition of myostatin and other proteins involved in the regulation of muscle mass.

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Research peptides are small chains of amino acids used in pure and applied biological research but not in the clinic. Although there is overlap in the definitions of both peptides and proteins, peptides are generally defined as a small chain of between 2 and 50 amino acids (AAs). Peptides are further differentiated based on size. Single unbranched strands between 10-20 AAs are called polypeptides, and oligopeptides are greater than 20 AAs long. Proteins are larger macromolecules consisting of hundreds to thousands of AAs that display secondary, tertiary, and quarternary structures.

Clinical and academic researchers have used research peptides to probe mechanisms underlying disease and as novel therapeutics. For example, one such study by Ahmed et al. investigated the effects of tatCN21 treatment in an animal model of global cerebral ischemia, the cessation or reduction of blood flow to the brain. TatCN21 is a 21 AA peptide inhibitor of the protein calcium-calmodulin (CaM) dependent protein kinase IIα (CaMKIIα) that is attached to a "tat sequence," which allows the peptide to be brought into the cell. Ahmed et al. found that treating rats with tatCN21 3 hours after GCI protected neurons against programmed cell death and reduced spatial memory deficits.

Another group investigated using a tat-conjugated peptide to block the interaction of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1). Nrf2 is an important transcription factor that activates the cellular antioxidation response and regulates signaling pathways in cancer and inflammation 5,6. Keap1 binds to Nrf2, preventing its activation and nuclear translocation . Steel et al. found that administering tat-conjugated peptide sequences that target this interaction could activate Nrf2 signaling and its downstream target genes in human THP-1 monocytes.

Many peptide hormones have been investigated for their potential beneficial properties in various diseases. Some of these, such as vasopressin, oxytocin, and insulin, have made it to the clinic, while others are in clinical trials ⁸. Currently, 80 peptide medications are approved for medical use. However, bringing new peptides to market requires careful consideration of renal clearance and delivery methods to make sure the drugs make it to their target tissue 9,10.

Research peptides have significantly advanced our understanding in health and disease. However, quality research requires peptides you can trust. Blue Sky Peptide sells the highest-grade research peptides on the market. In addition, we regularly offer BOGO deals, weekly promotions, and a rewards program that gives back when you shop with us. Check out our product catalog or contact us to see what Blue Sky Peptide can do for your research projects. All products from Blue Sky Peptide are for laboratory research only and are not suitable for human consumption. Any other use violates the terms and conditions for purchase.
References:

1. Forbes J, Krishnamurthy K. Biochemistry, Peptide. In: StatPearls. Treasure Island (FL)2021.

2. Friedberg F, Winnick T, Greenberg DM. Peptide synthesis in vivo. J Biol Chem. 1947;169(3):763.

3. Ahmed ME, Dong Y, Lu Y, Tucker D, Wang R, Zhang Q. Beneficial Effects of a CaMKIIalpha Inhibitor TatCN21 Peptide in Global Cerebral Ischemia. J Mol Neurosci. 2017;61(1):42-51.

4. Steel R, Cowan J, Payerne E, O'Connell MA, Searcey M. Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction. ACS Med Chem Lett. 2012;3(5):407-410.

5. Kobayashi M, Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal. 2005;7(3-4):385-394.

6. Moi P, Chan K, Asunis I, Cao A, Kan YW. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A. 1994;91(21):9926-9930.

7. Itoh K, Wakabayashi N, Katoh Y, et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999;13(1):76-86.

8. Muttenthaler M, King GF, Adams DJ, Alewood PF. Trends in peptide drug discovery. Nat Rev Drug Discov. 2021;20(4):309-325.

9. Mitragotri S, Burke PA, Langer R. Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat Rev Drug Discov. 2014;13(9):655-672.

10. Katz AI, Emmanouel DS. Metabolism of polypeptide hormones by the normal kidney and in uremia. Nephron. 1978;22(1-3):69-80.

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Fragment 176-191 is a small peptide that comprises the last 15 amino acids (AAs) from the c-terminal end of growth hormone (hGH). During childhood, hGH plays a critical role in growth regulation. However, in adulthood, hGH's most well-known function is metabolic. Among other actions, hGH stimulates insulin-like growth factor-1 (IGF-1) production and release. In addition, the release of hGH from the anterior pituitary gland is stimulated by hypothalamic growth hormone-releasing hormone (GHRH).

Fragment 176-191 and similar hGH fragments have powerful lipolytic and anti-lipogenic properties that have drawn researchers' interest for decades. Early investigation showed that injecting rats with c-terminal fragments of hGH caused a temporary increase in blood glucose and a more persistent boost in plasma insulin. Interestingly, fragments that did not contain AAs 178-191 had no effect. This provided crucial early evidence suggesting a minimum required sequence for a peptide to be biologically active.

Later research found that both hGH and the slightly truncated fragment 177-191 could cause weight loss in mice by promoting lipolysis, although a previous report suggests that it inhibits lipogenesis instead. Additionally, this study indicated that this is because the peptide sequence can boost the production of beta-3 adrenergic receptors (ADRB3) ⁸. Interestingly, it does not appear that fragment 177-191 acts on hGH receptors and, unlike hGH, does not stimulate cell proliferation. These results add to the body of evidence suggesting that hGH may be a prohormone with differentially truncated forms that have their own effects 6,10. Finally, fragment 177-191 co-injected with hyaluronic acid (HA) reduced cartilage degeneration and the degree of motor disability in a rat osteoarthritis model.

These results highlight the utility of fragment 176-191 and related peptides as valuable research tools. Although a phase 2B clinical trial investigating fragment 177-191 as a treatment for obesity stalled, hGH c-terminal fragments provide means to manipulate lipid metabolism in the lab without the interfering factors of IGF-1 signaling alterations or GH receptor. This specificity could one day help researchers uncover novel mechanisms and future therapies.

1. Wade JD, Ng FM, Bornstein J, Pullin CO, Pearce JS. Effect of C-terminal chain shortening on the insulin-antagonistic activity of human growth hormone 177--191. Acta Endocrinol (Copenh). 1982;101(1):10-14.

2. Brinkman JE, Tariq MA, Leavitt L, Sharma S. Physiology, Growth Hormone. In: StatPearls. Treasure Island (FL)2021.

3. Bidlingmaier M, Strasburger CJ. Growth hormone. Handb Exp Pharmacol. 2010(195):187-200.

4. Ayuk J, Sheppard MC. Growth hormone and its disorders. Postgrad Med J. 2006;82(963):24-30.

5. Vance ML. Growth-hormone-releasing hormone. Clin Chem. 1990;36(3):415-420.

6. Heffernan MA, Thorburn AW, Fam B, et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001;25(10):1442-1449.

7. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978;234(5):E521-526.

8. Heffernan M, Summers RJ, Thorburn A, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142(12):5182-5189.

9. Wu Z, Ng FM. Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone. Biochem Mol Biol Int. 1993;30(1):187-196.

10. Devesa J, Almenglo C, Devesa P. Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth? Clin Med Insights Endocrinol Diabetes. 2016;9:47-71.

11. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015;45(4):426-432.

12. Heike Stier EV, David Kenley. Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans. Journal of Endocrinology & Metabolism. 2013;3:7-15.

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Proteins and peptides are some of the most commonly used reagents in modern life sciences. From short-chain peptide receptor agonists to biotinylated-antibodies, peptide-based reagents play pivotal roles in every stage of research. The ubiquity of peptides has created a vibrant market for them and protein reagents with many suppliers at different levels. However, not all peptide suppliers are the same, and neither are their products. Therefore, the first step to ordering research peptides online is to identify whether a supplier's products are of the exacting standards needed to conduct effective research.

Bad reagents can ruin an experiment and potentially sink entire projects. More insidiously, research conducted with poorly tested components can get published and contribute to the growing reproducibility crisis in science ¹. In recent decades, irreproducibility has been brought to the forefront in science, with journals like Nature publishing extensively on the topic. In 2015, one study estimated that up to 50% of preclinical research is irreplicable. This has cost approximately $28,000,000,000 in US dollars ⁴.

One key point made by some authors is that differences in reagents, especially protein products like antibodies, have made achieving reproducible results difficult. Therefore, identifying which protein and peptide products are validated is crucial. There are databases and websites in which antibodies from different manufacturers are listed and compared for efficacy, with links to studies that use them ⁵. However, there is no such catalog or comparable resource for small peptide products. This doesn't mean that there is no way to be sure your peptide products are of the purity and quality you expect.

Peptide products should undergo quality control analysis through multiple methods. These techniques include high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance analysis (NMR) ⁷⁻⁹. A reputable supplier will have quality control reports available on their product pages for some or all of these. Therefore, when shopping for research peptides online, it is pivotal to find quality control reports.

Another factor to consider when shopping for research peptides online is customer service and accountability. Research is not a simple endeavor. Along the course of a project, it is a given that some experiments will not work out. In some cases, this is caused by the reagent. Even high-grade products will not work when used outside of their working conditions. By having direct contact with a peptide supplier, a researcher can troubleshoot issues that arise with their research peptide products. Additionally, a good return policy helps avoid losses if the product is not up to standards or does not match the application.

Finally, and perhaps most obviously, pricing is critical. Research funds aren't unlimited, and materials are only one of many costs that an investigator or lab manager must account for. Many suppliers offer scaling pricing options and periodic special offers. Additionally, some retailers have rewards programs that encourage repeat business.

When searching for research peptides online, Blue Sky Peptides offers affordable peptides that come with quality control reports. We have in-depth customer support and a generous return policy. In addition, our site has regular sales, BOGO offers, discount codes, and our BSP Rewards Program. Visit our website or contact us today to see if our research peptides will meet your research needs.

References:

1. Williams M. Reagent Validation to Facilitate Experimental Reproducibility. Curr Protoc Pharmacol. 2018;81(1):e40.

2. Baker M. 1,500 scientists lift the lid on reproducibility. Nature. 2016;533(7604):452-454.

3. Begley CG, Ioannidis JP. Reproducibility in science: improving the standard for basic and preclinical research. Circ Res. 2015;116(1):116-126.

4. Freedman LP, Cockburn IM, Simcoe TS. The Economics of Reproducibility in Preclinical Research. PLoS Biol. 2015;13(6):e1002165.

5. Antibodypedia. https://www.antibodypedia.com/. Accessed August 28, 2021.

6. Vergote V, Burvenich C, Van de Wiele C, De Spiegeleer B. Quality specifications for peptide drugs: a regulatory-pharmaceutical approach. J Pept Sci. 2009;15(11):697-710.

7. Choules MP, Bisson J, Gao W, et al. Quality Control of Therapeutic Peptides by (1)H NMR HiFSA Sequencing. J Org Chem. 2019;84(6):3055-3073.

8. Stalmans S, Gevaert B, Verbeke F, et al. Quality control of cationic cell-penetrating peptides. J Pharm Biomed Anal. 2016;117:289-297.

9. Zeng K, Geerlof-Vidavisky I, Gucinski A, Jiang X, Boyne MT, 2nd. Liquid Chromatography-High Resolution Mass Spectrometry for Peptide Drug Quality Control. AAPS J. 2015;17(3):643-651.

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Bremelanotide is a 7 amino acid (AA) analogue of α melanocyte-stimulating hormone (α-MSH) used in scientific research studies as a treatment for hyposexual sexual desire disorder (HSDD) in women. As a peptide, bremelanotide is injected subcutaneously, although intranasal administration has shown efficacy in stimulating sexual arousal in female vitro test subjects. Male vitro test subjects with sexual dysfunction also demonstrate increased sexual arousal and erectile responses after subcutaneous bremelanotide injection, including subjects for whom Viagra was ineffective. In addition to its beneficial role in sexual dysfunction studies, bremelanotide has excellent utility in many different fields of neuroscience research.

DISCLAIMER: All products from Blue Sky Peptide are for laboratory research only and are not suitable for human consumption. Any other use violates the terms and conditions for purchase. Bremelanotide should only be used in carefully controlled laboratory conditions with appropriate personal protective equipment. If exposure occurs, immediately rinse the affected area and seek medical help if symptoms present.

Bremelanotide is a melanocortin receptor (MCR) agonist that preferentially interacts with the melanocortin receptor subtype 4 (MC4R). The melanocortins and their receptors were first identified as pituitary factors involved in skin darkening in frogs. Eventually, however, the exploration of the melanocortin system extended to mammalian systems. The melanocortin system contributes to skin pigmentation, inflammation, appetite, memory, and sexual behavior.

The different MCR subtypes play distinct roles and are differentially expressed across the body. Melanocortins, also known as melanocyte-stimulating hormones (MSH), are all small peptide hormones derived from proopiomelanocortin and serve as the primary agonists of MCRs along with adrenocorticotropic hormone (ACTH)⁹. MSH peptides come in 3 types: α-MSH, β-MSH, γ-MSH.

MC4R is primarily localized in the brain and is considered a neural MCROne of the primary roles of MC4R is regulating food intake by mediating the effects of leptin. Administering α-MSH reduces feeding in obese rats, especially when applied directly to the paraventricular nucleus of the hypothalamus (PVN), a critical autonomic control center of the brain involved with stress responses, growth, and reproduction. In addition to food intake, MC4R plays a role in other processes like glucose and lipid homeostasis, disease-associated lean body mass wasting, and cardiovascular function.

Reproductive behavior is also intrinsically tied to MC4R and its ligands. Mice with reduced or absent MC4R function exhibit several sexual dysfunctions. Administration of MC4R agonist reversed these effects in some studies and caused erections and ejaculations in some animal models after central nervous system administration.

Considering the breadth of life-essential roles the melanocortin system has, an MC4R-specific agonist like bremelanocortin is valuable for many lines of neuroscience research. In addition, bremelanocortin is extensively characterized in the literature and is well-tolerated by many species, including rats and humans. Therefore, bremelanocortin is, and has been, a powerful research tool.

References:

1. Mayer D, Lynch SE. Bremelanotide: New Drug Approved for Treating Hypoactive Sexual Desire Disorder. Ann Pharmacother. 2020;54(7):684-690.

2. Clayton AH, Althof SE, Kingsberg S, et al. Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial. Womens Health (Lond). 2016;12(3):325-337.

3. Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004;16(2):135-142.

4. Pfaus JG, Sadiq A, Spana C, Clayton AH. The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women. CNS Spectr. 2021:1-9.

5. Wikberg JE, Muceniece R, Mandrika I, et al. New aspects on the melanocortins and their receptors. Pharmacol Res. 2000;42(5):393-420.

6. Shen Y, Fu WY, Cheng EY, Fu AK, Ip NY. Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism. J Neurosci. 2013;33(2):464-472.

7. Catania A, Lonati C, Sordi A, Carlin A, Leonardi P, Gatti S. The melanocortin system in control of inflammation. ScientificWorldJournal. 2010;10:1840-1853.

8. Ellacott KL, Cone RD. The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philos Trans R Soc Lond B Biol Sci. 2006;361(1471):1265-1274.

9. Gantz I, Fong TM. The melanocortin system. Am J Physiol Endocrinol Metab. 2003;284(3):E468-474.

10. Tao YX. The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev. 2010;31(4):506-543.

11. Kask A, Rago L, Wikberg JE, Schioth HB. Evidence for involvement of the melanocortin MC4 receptor in the effects of leptin on food intake and body weight. Eur J Pharmacol. 1998;360(1):15-19.

12. Ferguson AV, Latchford KJ, Samson WK. The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction. Expert Opin Ther Targets. 2008;12(6):717-727.

13. Hansen MJ, Ball MJ, Morris MJ. Enhanced inhibitory feeding response to alpha-melanocyte stimulating hormone in the diet-induced obese rat. Brain Res. 2001;892(1):130-137.

14. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol. 1994;8(10):1298-1308.

15. Sandrock M, Schulz A, Merkwitz C, Schoneberg T, Spanel-Borowski K, Ricken A. Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice. Reprod Biol Endocrinol. 2009;7:24.

16. Irani BG, Xiang Z, Moore MC, Mandel RJ, Haskell-Luevano C. Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse. Biochem Biophys Res Commun. 2005;326(3):638-644.

17. Van der Ploeg LH, Martin WJ, Howard AD, et al. A role for the melanocortin 4 receptor in sexual function. Proc Natl Acad Sci U S A. 2002;99(17):11381-11386.

18. Bertolini A, Tacchi R, Vergoni AV. Brain effects of melanocortins. Pharmacol Res. 2009;59(1):13-47.

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Bremelanotide is a 7 amino acid (AA) analogue of α melanocyte-stimulating hormone (α-MSH) used in scientific research studies as a treatment for hyposexual sexual desire disorder (HSDD) in women. As a peptide, bremelanotide is injected subcutaneously, although intranasal administration has shown efficacy in stimulating sexual arousal in female vitro test subjects. Male vitro test subjects with sexual dysfunction also demonstrate increased sexual arousal and erectile responses after subcutaneous bremelanotide injection, including subjects for whom Viagra was ineffective. In addition to its beneficial role in sexual dysfunction studies, bremelanotide has excellent utility in many different fields of neuroscience research.

DISCLAIMER: All products from Blue Sky Peptide are for laboratory research only and are not suitable for human consumption. Any other use violates the terms and conditions for purchase. Bremelanotide should only be used in carefully controlled laboratory conditions with appropriate personal protective equipment. If exposure occurs, immediately rinse the affected area and seek medical help if symptoms present.

Bremelanotide is a melanocortin receptor (MCR) agonist that preferentially interacts with the melanocortin receptor subtype 4 (MC4R). The melanocortins and their receptors were first identified as pituitary factors involved in skin darkening in frogs. Eventually, however, the exploration of the melanocortin system extended to mammalian systems. The melanocortin system contributes to skin pigmentation, inflammation, appetite, memory, and sexual behavior.

The different MCR subtypes play distinct roles and are differentially expressed across the body. Melanocortins, also known as melanocyte-stimulating hormones (MSH), are all small peptide hormones derived from proopiomelanocortin and serve as the primary agonists of MCRs along with adrenocorticotropic hormone (ACTH)⁹. MSH peptides come in 3 types: α-MSH, β-MSH, γ-MSH.

MC4R is primarily localized in the brain and is considered a neural MCROne of the primary roles of MC4R is regulating food intake by mediating the effects of leptin. Administering α-MSH reduces feeding in obese rats, especially when applied directly to the paraventricular nucleus of the hypothalamus (PVN), a critical autonomic control center of the brain involved with stress responses, growth, and reproduction. In addition to food intake, MC4R plays a role in other processes like glucose and lipid homeostasis, disease-associated lean body mass wasting, and cardiovascular function.

Reproductive behavior is also intrinsically tied to MC4R and its ligands. Mice with reduced or absent MC4R function exhibit several sexual dysfunctions. Administration of MC4R agonist reversed these effects in some studies and caused erections and ejaculations in some animal models after central nervous system administration.

Considering the breadth of life-essential roles the melanocortin system has, an MC4R-specific agonist like bremelanocortin is valuable for many lines of neuroscience research. In addition, bremelanocortin is extensively characterized in the literature and is well-tolerated by many species, including rats and humans. Therefore, bremelanocortin is, and has been, a powerful research tool.

References:

1. Mayer D, Lynch SE. Bremelanotide: New Drug Approved for Treating Hypoactive Sexual Desire Disorder. Ann Pharmacother. 2020;54(7):684-690.

2. Clayton AH, Althof SE, Kingsberg S, et al. Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial. Womens Health (Lond). 2016;12(3):325-337.

3. Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004;16(2):135-142.

4. Pfaus JG, Sadiq A, Spana C, Clayton AH. The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women. CNS Spectr. 2021:1-9.

5. Wikberg JE, Muceniece R, Mandrika I, et al. New aspects on the melanocortins and their receptors. Pharmacol Res. 2000;42(5):393-420.

6. Shen Y, Fu WY, Cheng EY, Fu AK, Ip NY. Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism. J Neurosci. 2013;33(2):464-472.

7. Catania A, Lonati C, Sordi A, Carlin A, Leonardi P, Gatti S. The melanocortin system in control of inflammation. ScientificWorldJournal. 2010;10:1840-1853.

8. Ellacott KL, Cone RD. The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philos Trans R Soc Lond B Biol Sci. 2006;361(1471):1265-1274.

9. Gantz I, Fong TM. The melanocortin system. Am J Physiol Endocrinol Metab. 2003;284(3):E468-474.

10. Tao YX. The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev. 2010;31(4):506-543.

11. Kask A, Rago L, Wikberg JE, Schioth HB. Evidence for involvement of the melanocortin MC4 receptor in the effects of leptin on food intake and body weight. Eur J Pharmacol. 1998;360(1):15-19.

12. Ferguson AV, Latchford KJ, Samson WK. The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction. Expert Opin Ther Targets. 2008;12(6):717-727.

13. Hansen MJ, Ball MJ, Morris MJ. Enhanced inhibitory feeding response to alpha-melanocyte stimulating hormone in the diet-induced obese rat. Brain Res. 2001;892(1):130-137.

14. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol. 1994;8(10):1298-1308.

15. Sandrock M, Schulz A, Merkwitz C, Schoneberg T, Spanel-Borowski K, Ricken A. Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice. Reprod Biol Endocrinol. 2009;7:24.

16. Irani BG, Xiang Z, Moore MC, Mandel RJ, Haskell-Luevano C. Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse. Biochem Biophys Res Commun. 2005;326(3):638-644.

17. Van der Ploeg LH, Martin WJ, Howard AD, et al. A role for the melanocortin 4 receptor in sexual function. Proc Natl Acad Sci U S A. 2002;99(17):11381-11386.

18. Bertolini A, Tacchi R, Vergoni AV. Brain effects of melanocortins. Pharmacol Res. 2009;59(1):13-47.

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With Purchase over $99 | USA ONLY

Unit Size

5 mg/vial

Unit Quantity

1 vial

Purity (HPLC)

99.03%

Sequence

His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

Molecular Formula

C46H56N12O6

Molecular Weight

873.01

Appearance

lyophilized White Powder

Source

Chemical Synthesis

Storage

Lyophilized GHRP-6 is Stable at room
Temperature for 90 days, however it is best to store in a freezer
below - 8c for any extended
period of time. After reconstitution GHRP-6 should be
refrigerated at temperatures not to exceed 35 F.

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

GHRP-6 (growth hormone releasing peptide 6) is a synthetic compound made of six amino acids. It can elicit the release of growth hormone (GH)1. Early work on GHRP-6 and similar peptides indicated that they have no structural similarity to growth hormone releasing hormone, however2. There are two analogs of GHRP-6; GHRP-6 peptide and [D-Lys-3]-GHRP-6. [D-Lys-3]-GHRP-6 has an antagonist effect on the GH secretagogue receptor (GHS-R), or the receptor for ghrelin3. Therefore, such a peptide may be used in animal studies that assess the role of this important biomolecule in various processes related to hunger and metabolic regulation. For example, ghrelin may have a role in enhancing the release of insulin in response to food intake, through the release of GLP-1 from specialized cells in the intestine4. [D-Lys-3]-GHRP-6 has demonstrated the ability to counteract this effect4. It may also be used to determine the locations of the GHS-R, e.g. in the ventral tegmental area of the brain3. [D-Lys-3]-GHRP-6 has demonstrated the ability to reduce the extent of DNA synthesis in the gastric glands of infant rats, indicating a role for ghrelin in the development of the stomach after birth5.

The GHRP-6 peptide, on the other hand, has a dose-dependent agonist effect on the GHS receptor6. However, it appears not to match ghrelin in terms of specificity6. GHRP-6 has demonstrated positive effects on organ growth and regeneration in various studies. Its administration resulted in a threefold increase in the migration, but not proliferation, of rat-intestine epithelial cells, indicating a role for the peptide in restoring gut function7. Intraperitoneal GHRP-6 peptide (at a concentration of 120 μg/kg) also significantly inhibited the effects of an animal model of multiple organ damage (i.e. ischemia-reperfusion injury)7. A combination of GHRP-6 and recombinant human epidermal growth factor (administered at concentrations of either 100 or 600 μg per kg) had a significantly detrimental effects on the neurological damage expected as a result of experimentally-induced ischemic stroke in gerbils8.

References: 1. Pimentel-Filho FR, Ramos-Dias JC, Ninno FB, Facanha CF, Liberman B, Lengyel AM. Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism. Clinical endocrinology. 1997;46(3):295-300. 2. Ghigo E, Arvat E, Muccioli G, Camanni F. Growth hormone-releasing peptides. European journal of endocrinology / European Federation of Endocrine Societies. 1997;136(5):445-460. 3. St-Onge V, Watts A, Abizaid A. Ghrelin enhances cue-induced bar pressing for high fat food. Hormones and behavior. 2015;78:141-149. 4. Gagnon J, Baggio LL, Drucker DJ, Brubaker PL. Ghrelin Is a Novel Regulator of GLP-1 Secretion. Diabetes. 2015;64(5):1513-1521. 5. Bittar NM, Zulian JG, Ogias D, Gama P. Ghrelin and GHS-R in the rat gastric mucosa: Are they involved in regulation of growth during early weaning? Nutrition (Burbank, Los Angeles County, Calif.). 2016;32(1):101-107. 6. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-660. 7. Cibrian D, Ajamieh H, Berlanga J, et al. Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure. Clinical science (London, England : 1979). 2006;110(5):563-573. 8. Subiros N, Perez-Saad HM, Berlanga JA, et al. Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy. Neurological research. 2015:1743132815y0000000089.

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Buy 1 Get 1 Free IPAMORELIN 2000mcg From Blue Sky Peptide

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Unit Size

2 mg/vial

Unit Quantity

1 vial

Purity (HPLC)

98.21%

Sequence

H-Aib-His-D-2-Nal-D-Phe-Lys-Ile-NH2

Molecular Formula

C38H49N9O5

Molecular Weight

711.86

Appearance

lyophilized White Powder

Source

Chemical Synthesis

Storage

Lyophilized IPAMORELIN is Stable at room
Temperature for 90 days, however it is best to store in a freezer
below - 8c for any extended
period of time. After reconstitution IPAMORELIN should be
refrigerated at temperatures not to exceed 35 F.

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
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Buy Peptides Online | Peptides & Research Liquids for Sale

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Research Grade Pramipexole

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Unit Size

60mg/ bottle

Unit Quantity

1 bottle

Application

Molecular Formula

C10H17N3S

Molecular Weight

211.33

Appearance

Clear

Physical State

Liquid

Storage

Room Temperature

Terms

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research use only. Please familiarize yourself with
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JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser. Research Grade Pramipexole Free Priority Shipping With Purchase over $99 | USA ONLY Unit Size 60mg/ bottle Unit Quantity 1 bottle Application Molecular Formula C10H17N3S Molecular Weight 211.33 Appearance Clear Physical State Liquid Storage Room Temperature Terms The products we offer are intended for laboratory research use only.

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SNAP 8 peptide's scientific name is Acetyle Glutamyl Heptapeptide-1. It is being tested for use for anti-wrinkle solutions. Studies show that SNAP 8 has properties that enable it to reduce the depth of wrinkles that are caused by everyday muscle contractions. In animal test subjects, it has shown significant results around the eyes and forehead. This product is considered to be a milder, more cost-effective and safer alternative to Botulinum Toxin. SNAP 8 works similarly to Botulinum Toxin by targeting the same wrinkle formations, but in a unique way.
Test Results of SNAP 8 Peptide
VIVO testing was performed to determine how effective small peptides are with providing stability for the SNARE complex. This allowed the researchers to follow the thermal stability and formation of the reconstituted SNARE protein complex. This basically evaluates the effectiveness of the peptides that are patterned like SNAP-25 N and its ability to amass with synaptobrein and syntaxin that is being formed with the SNARE complex. The final result was that the short peptides that came from the N-terminal end of SNP-25 were able to compete with the natural protein and stop it from forming SNARE complex by changing the stability.

Another test was done with test subjects. The cream used consisted of 10 percent SNAP 8. Researchers obtained silicon imprints from around the eyes of 17 test subjects. These silicon imprints were taken before the test began. The test subjects applied the cream twice daily, and then another sample was taken 28 days later. The imprints were analyzed using control laser scanning microscopy to see the difference between the skin surface of the sample taken before and after treatment. In order to see a three dimensional view of the samples, skin topography images were created. Within these images, it was observed that the depth of the wrinkles had decreased significantly after receiving treatment for 28 days. The max reduction that was seen with the 10 percent SNAP 8 solution was 63.18 percent.
How SNAP 8 Peptides Work
SNAP 8 is a copy of the N-terminal end of SNAP-25. This competes with SNAP-25 to position itself within the SNARE complex, which then modulates its creation. When the SNARE complex is destabilized slightly, it is impossible for the vesicle to release neurotransmitters in an efficient manner. Because of this, muscle contractions are reduced, so that wrinkles and lines are prevented. It will also help reduce existing fine lines and wrinkles by inhibiting the formation of SNARE complex and the release of catecholamine. With regular use in test subjects, it also prevented the development of wrinkles and lines.

Clinical studies show that SNAP 8 helped to reduce wrinkles surrounding the eyes by up to 63.13 percent. Testing for vitro and vivo efficiency showed that SNAP 8 has 30 percent more activity than parent peptides like Argireline.

Disclaimer: SNAP 8 peptide is a solution that is still currently being tested in the scientific community. It is not intended for use on humans or animals. It is recommended to purchase SNAP 8 for the sole purpose of experimentation within a laboratory setting. It should not be purchased and used for any other reason. This substance has not been approved for use by people. It is recommended that experiments conducted with SNAP 8 be performed under experimental circumstances that are under strict lab guidelines. Safety equipment should be used at all times throughout experimentation with this product. In the event that someone is exposed to the substance, thorough cleansing of the area immediately after is recommended to avoid potential harm.

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SNAP 8 peptide's scientific name is Acetyle Glutamyl Heptapeptide-1. It is being tested for use for anti-wrinkle solutions. Studies show that SNAP 8 has properties that enable it to reduce the depth of wrinkles that are caused by everyday muscle contractions.

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What Epitalon Does In Research Experiments

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What Epitalon Does In Research Experiments

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There is a lot of speculation as to what the peptide Epitalon may be capable of under the right research conditions. When it comes to animal testing, this peptide seems to hold a lot of promise in teaching researchers what happens with cellular exposure. If you have considered beginning or resuming research on the peptide Epitalon, here are some things you should make sure you are aware of.

What Epitalon Looks Like

More often than not, researchers begin working with Epitalon in its lyophilized powder state. This powder is then able to be diluted in water or a mild 1% solution of acetic acid. In its powder state, Epitalon is stable at room temperature for approximately three months. Once diluted, however, the peptide requires a storage temperature of 4 degrees centigrade. At that temperature, Epitalon can safely be used for research for anywhere from two to twenty-one days. If you need the solution to last longer for your research purposes, you need to store it at negative eighteen degrees centigrade.

What Epitalon Does in Research Experiments

When Epitalon is used in experiments, scientists are noticing quite a few promising side effects. Scientists have long known that telomere is partly responsible for the aging of cells and organ function. One of the side effects that cells and organs are showing when exposed to Epitalon is the elongation of telomere, effectively slowing, stopping, or even reversing the effects of aging at the cellular level. There have even been some signs that cells have begun to regenerate and heal after Epitalon exposure. When looked at under a microscope, animal cells are even showing that some correction is coming at the level of the animal's DNA, allowing for incredible results with cellular regeneration and repair.

Epitalon has also shown researchers that it has been able to control the animal's levels of cortisol, melatonin, and re-regulate some issues within female rat's reproduction systems. This regulation is teaching scientists about how cells control themselves, allowing them to learn about each system and how it functions. When Epitalon was exposed to tumors, some different types of tumors shrank and even reversed some of the damage they had caused during their growth. However, one of the most astounding side effects that researchers have begun to notice is that the test subjects are living longer than those not exposed to Epitalon. Some of the subjects have even decreased their mortality rate by as much as 50%, allowing them to live nearly 1.5 times longer than their counterparts that were only exposed to placebos. The rats that lived the extra time after Epitalon also avoided developing any form of Leukemia, which was not true for the control group that only received the placebo.

Epitalon is showing quite a bit of promise when it comes to offering researchers a way to study the effects of aging and how to reverse it within the animal world. If your research is leading you down the same path, you could gain a lot of value from the research that working with Epitalon can provide. Just make sure that you get your peptides from the most reputable place you can find so that all of your results are accurate, safe, and repeatable by other scientists on a long-term basis.

Please Note: Epitalon is not made or intended for any type of human consumption. In fact, exposure through methods such as injection and ingestion is dangerous and can have long-term, harmful effects on the human body. Researchers need to be sure to follow proper procedures when handling Epitalon, just like they should with any peptide. Do not ever use Epitalon for any reason aside from research purposes, and make sure all exposure is follows all proper safety procedures.

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There is a lot of speculation as to what the peptide Epitalon may be capable of under the right research conditions. When it comes to animal testing, this peptide seems to hold a lot of promise in teaching researchers what happens with cellular exposure.

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Special Price $42.50 Regular Price $50.95

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Buy PEG MGF 2 mg :

Unit Size

2 mg/vial

Unit Quantity

1 vial

Purity (HPLC)

98.78%

Sequence

PEG-Suc-YQPPSTNKNTKSQ(d)R(d)RKGSTFEEHKNH2

Molecular Formula

C121H200N42O39

Appearance

lyophilized White Powder

Source

Chemical Synthesis

Storage

Lyophilized PEG MGF is Stable at room
Temperature for 90 days, however it is best to store
in a freeze below - 8c for any extended period of time.
After reconstitution PEG MGF should be
refrigerated at temperatures not to exceed 35 F.

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
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Shop T3 (liothyronine) 100 mcg From Blue Sky Peptide

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Molecular Formula

C15H1213NO4

Molecular Weight

651

Appearance

Clear

Physical State

Liquid

Storage

Room Temperature

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
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Click here to read more detail on our research blog.

Download T3 HPLC Quality Report

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antiestrogen with potent anti-cancer and PKC inhibitory activities

Molecular Formula

C32H37NO8

Molecular Weight

563.7

Appearance

suspension

Physical State

Liquid

Storage

Room Temperature

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
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Blogs On CJC-1295 No DAC | Blue Sky Peptide

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Blogs On CJC-1295 No DAC | Blue Sky Peptide

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CJC-1295 is an isoform of the growth hormone releasing hormone (GHRH), also popularly known as GH-releasing factor or GRF. This protein is produced in the hypothalamus of many animals, and targets receptors on somatotrophic cells in the pituitary when released ¹. It may be applied as a treatment for growth disorders, or with the intention of tissue mass enhancement; in which case it is bound to a drug-affinity complex (or DAC) which is intended to control its release over time when administered. However, the peptide as referred to in the title above is CJC-1295 NO-DAC, or modified GRF without DAC i. Therefore, it may also be referred to as modGRF, or the first 29 amino acids that comprise the original GRF molecule i. Native GRF, on the other hand, may have as many as 44 amino acids ², although residues 1-29 have been shown to exert all the biological properties associated with this protein ³. modGRF weighs just under 3.4kDa, is synthetically produced and is suitable for research use only i. The main function of modGRF is to enhance the release of GH, as mentioned above. Therefore, it may be useful in studies of growth and development. Some studies indicate that modGRF has pharmacokinetic and pharmacokinetic properties that are superior to endogenous GHRH ⁴. It may have increased activity in vivo and a greater half-life compared to un-modified GRF ⁴.

Human GRF (or GRF1-44) may be regarded as a 'reference' GRF, and was used as a template for many GRF analogs. However, its modification in respect to the isoforms of other species may confer benefits. For example, substituting the first two amino acids for those of the murine sequence reportedly inhibits metabolism by a peptidase, thus improving stability in cell culture studies ². Additionally, replacing the eighth residue in the human sequence (asparagine) with serine, (as in the rat sequence) threonine (mouse) or glutamine (synthetic) results in further stability and enhanced conformity to one peptide conformation ². Substituting alanine for the original glycine at the fifteenth residue is thought to increase receptor binding ². Another measure of GRF optimization is truncation, as outlined above. This may make improve many factors of potency for this molecule ².

GRF has other targets beside GH. The administration of CJC-1295 has resulted in significant increases in the release of IGF-1 ³. Endogenous GRF, GH and IGF-1 form a regulatory 'axis' that may also control pro-inflammatory mechanisms when activated ⁵. The peptide has also demonstrated the ability to reduce growth deficits in a mouse model of GHRH knockout. Knockout mice treated with 2µg CJC-1295 daily for five weeks achieved significantly increased total body weight and length compared to placebo-treated knockout animals ⁶. The body weight and length of knockout mice treated daily with CJC-1295 was also comparable to 'normal' untreated mice ⁶. Therefore, modGRF may also have profound effects on growth in experimental animals. It may also be used to assess the abnormal response to GRF that has been observed in rodent models of obesity ⁷. Rats with genetically-induced obesity have exhibited significant decreases in GH release following treatment with GRF in a time-dependent manner (i.e. at eight weeks following birth compared to six weeks) ⁷. In summary, modGRF is a useful lab-grade peptide that may be applied to studies of growth, development and metabolic disorders.
References:

1. Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Activation of the GH/IGF-1 axis by CJC-1295, a long acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2009;19(6):471-477.

2. Campbell RM, Stricker P, Miller R, et al. Enhanced stability and potency of novel growth hormone-releasing factor (GRF) analogues derived from rodent and human GRF sequences. Peptides. 1994;15(3):489-495.

3. Ionescu M, Frohman LA. Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog. The Journal of Clinical Endocrinology & Metabolism. 2006;91(12):4792-4797.

4. Jette L, Leger R, Thibaudeau K, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146(7):3052-3058.

5. Qin YJ, Chan SO, Chong KKL, et al. Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(51):18303-18308.

6. Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American journal of physiology. Endocrinology and metabolism. 2006;291(6):E1290-1294.

7. Renier G, Gaudreau P, Deslauriers N, Petitclerc D, Brazeau P. Dynamic of the GRF-induced GH response in genetically obese Zucker rats: influence of central and peripheral factors. Regulatory peptides. 1990;28(1):95-106.

CJC-1295 NO-DAC Product Page. Bluesky Peptides. 2016

# data[].attributes.attachment_link.description
CJC-1295 is an isoform of the growth hormone releasing hormone (GHRH), also popularly known as GH-releasing factor or GRF. This protein is produced in the hypothalamus of many animals, and targets receptors on somatotrophic cells in the pituitary when released.

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Shop IGF-1 LR3 1mg | 45% Off Your Order | Blue Sky Peptide

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Shop IGF-1 LR3 1mg | 45% Off Your Order | Blue Sky Peptide

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Unit Size

1 mg/vial

Unit Quantity

1 vial

Purity (HPLC)

96.35%

pH

7.05

Bacterial Endotoxins

<5EU/mg

Molecular Weight

Conformed

Appearance

lyophilized White Powder

Source

Recombinant Synthesis

Storage

Lyophilized IGF-1 LR3 is Stable at room
Temperature for 90 days, however it is best to store in a freezer
below - 8c for any extended
period of time. After reconstitution IGF-1 LR3 should be
refrigerated at temperatures not to exceed 35 F.

Terms

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research use only. Please familiarize yourself with
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IGF-1 is regarded as a peptide hormone, an endocrine factor and a paracrine factor, depending on the part of the body in which it is active. It is available as a laboratory-grade compound known as IGF-1 LR3. Research use only.

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Shop PT-141 (Bremelanotide) 10mg From Blue Sky Peptide

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10 mg/vial

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98.94%

Sequence

Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH

Molecular Formula

C50H68N14O10

Molecular Weight

1025.2

Appearance

lyophilized White Powder

Source

Chemical Synthesis

Storage

Lyophilized PT-141 is Stable at room
Temperature for 90 days, however it is best to store
in a freezer below - 8c for any extended period of time.
After reconstitution PT-141 should be
refrigerated at temperatures not to exceed 35 F.

Terms

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2 mg/ vial

Unit Quantity

1 vial

Purity (HPLC)

99.48%

Sequence

Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu- Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys- Gln-Ala-Gly-Glu-Ser-OH

Molecular Formula

C212H350N56O78S

Molecular Weight

4963.55

Net Weight

100.0mg

Appearance

lyophilized White Powder

Source

Chemical Synthesis

Storage

Lyophilized TB500 is Stable at room
Temperature for 90 days, however it is best to store
in a freezer below - 8c for any extended
period of time. After reconstitution TB500 should be
refrigerated at temperatures not to exceed 35 F.

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

Click here to read more detail about TB 500 Peptide on our research blog

Download Tb500 Certificate of Analysis

Download tb500 HPLC Report

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A CYP19 (aromatase) inhibitor

Molecular Formula

C17H19N5

Molecular Weight

293.37

Appearance

Clear

Physical State

Liquid

Storage

Room Temperature

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

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H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH

Molecular Formula

C62H98N16O22

Molecular Weight

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Net Weight

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Appearance

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Source

Chemical Synthesis

Storage

Lyophilized BPC 157 is Stable at room
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ACE-031 is categorized within the protein family. It is consistently used in laboratory research to determine its ability to improve muscle mass. This protein is also being used for research in regards to neuromuscular disease treatment. The hypothesis of the studies is to see whether ACE-031 can be used to preserve physical function and boost strength of test subjects. Studies are still ongoing, so more is being learned on a regular basis about what this peptide can do. Proteins like ACE-031 are not approved for human consumption.
What Exactly is ACE-031?
This is a protein that's being investigated to determine if it can be used for therapeutic purposes for building muscle and enhancing the strength of test subjects. It does this by allowing molecules to bind to cell surface receptors - this is also where it signals through. These cell surface receptors are known as Activin Receptr Type IIB, also known as ActRIIB. ACE-031 is a recombinant fusion protein that is produced when a portion of the ActRIIB receptor and a part of the standard antibody are joined together. This then creates a decoy version of ActRIIB that circulates and eliminates proteins like GDF-8 (also known as myostatin) and other molecules that limit the muscle's strength or growth.
How the ActRIIB Sends Signals and Promotes Muscle Growth
The proteins in the TGF-B superfamily are used to regulate muscle growth. These act as the on and off switch for the production of muscles. In order to stop muscle growth, several molecules, such as GDF-8, intermingle with the ActRIIB receptor, which stops the production of muscle. When these off switches aren't present, the muscle increases in mass radically.
Studies Using ACE-031 for Building Muscles
When ACE-031 was administered to test subjects, it showed that it helps to promote muscle growth and inhibit signaling from ActRIIB receptors. ACE-031 then binds together with other proteins that use the ActRIIB receptors to signal a limitation to muscle growth. Once bonded with these proteins, ACE-O31 stops communication with the ActRIIB, which then allows muscles to increase in size. Since ACE-031 stops certain proteins from sending signals through the ActRIIB, its effect on lean muscle exceeds those of just myostatin alone.

When used on test subjects, ACE-031 shows growth of lean muscle and increased strength over test subjects that haven't been treated with the protein. This has been used on healthy test subjects and those with diseases related to muscle wasting and weakness.

For research involving skeletal muscle building, a single dose of ACE-031 was administered to test subjects. In two weeks, over two pounds of muscle was developed in those test subjects. It was also noted that the ACE-031 decreased leptin and increased adiponectin, which altered the biomarkers of fat metabolism and the formation of bone. It also changed resorption due to the decreased CTX and increased BSAP. The side effects of ACE-031 doses of different levels were mild or transient. No serious adverse effects were seen. Some of the adverse effects that were witnessed in test subjects included bleeding from the nose, signs of a headache and reactions at the injection site. The half-life of ACE-031 is 12 days, according to research.

Disclaimer: ACE-031 is not intended for use in humans. The studies that were performed using this protein were for the purpose of research and experimentation only. It's not recommended for purchase for any other reason than for testing. It is advised that any research conducted using ACE-031 should be done in an experimental setting that complies with strict lab guidelines. It is important that safety equipment be worn while experimenting with ACE-031. If one of the researchers is exposed to the protein, the area should be cleansed thoroughly to avoid adverse reactions.

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ACE-031 is categorized within the protein family. It is consistently used in laboratory research to determine its ability to improve muscle mass. This protein is also being used for research in regards to neuromuscular disease treatment. The hypothesis of the studies is to see whether ACE-031 can be used to preserve physical function and boost strength of test subjects.

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What is Follistatin 344? | Visit Blue Sky Peptide To Know More

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Follistatin 344 (or FS-344) acts as a precursor to the protein follistatin when administered to animals as a laboratory-grade peptide. Mature follistatin regulates the release of follicle-stimulating hormone (FSH) through the inhibition of activin ¹. Naturally, activin (also known as activin-A) is classically viewed as an FSH-level promoter, although it may have other roles in accordance to the part of the body in which it is present. Therefore, FS-344 may be present in any tissue that also contains activin (according to some studies on rats). These include skeletal muscle, several vital organs, the thymus and part of the cerebral cortex, although the majority of follistatin molecules may be found in the gonads and anterior pituitary ². Follistatin also has other targets in vivo, the best-studied of which are myostatin and growth differentiation factor-11 (GDF-11) ¹. This may be due to the close homogeneity in structure between activin and these additional proteins ³. Myostatin and GDF-11 were also perceived as similar in function at one time, although more up-to-date research indicates that they have wildly different roles in mammalian systems ³. Myostatin is associated with muscle development after birth, whereas GDF-11 has more diverse functions in development ³. This suggests a diverse range of future applications for follistatin and for derivatives such as FS-344.

There are a number of applications for FS-344 in the laboratory and in animal studies. These may mostly concern experiments on the roles of activin in various tissues, due to the influence of follistatin on this protein. FS-344 is composed of all the amino acids that can comprise the protein, whereas species-specific isoforms are spliced or further processed into slightly smaller variants (e.g. FS-315) ⁴. The presence of FS-344 mRNA was originally confirmed in porcine studies ⁵. It has also been found in rats, and stood out at the time as the most abundant messenger RNA associated with follistatin precursors (of which there are indeed others, e.g. FS-317) in this animal ². FS-344 also distinguishes itself through a novel 27-amino acid tail at the C-terminus, which other smaller follistatin precursors lack ⁵. Follistatin derivatives have also recently attracted attention as research agents in murine models of muscle growth and development 1,6. This is due to the inhibitory effects of the protein on myostatin, which has a role in the negative regulation of cardiac and skeletal muscle mass ³.

Some groups have also reported results suggesting roles for follistatin and/or its derivatives in inflammatory processes, scar tissue formation, hair growth and tissue re-modeling 4,7,8. The anti-inflammatory effects of follistatin are most likely to be due to its binding of activin, which has been shown to be released in response to animal models of immune-system challenge ⁸. Follistatin may also reduce mortality in these animals, due to the neutralization of activin and, thus, increased inflammation ⁸. However, activin may also promote tissue re-modeling. Therefore, follistatin may be used to selectively modulate tissue regeneration, leading to the improved control of wound healing and fibrosis in animals affected by disorders of the relevant processes ⁸. Few formal studies have been conducted to elucidate the pharmacokinetics or pharmacodynamics of FS-344. However, a study of the same of the splice-variant FS-315 suggests that follistatin exhibits rapid clearance and limited distribution ⁴. Therefore, local (e.g. intramuscular for muscle mass and/or regeneration studies) as opposed to systemic administration may be advisable when incorporating FS-344 into a study.
References:

1. Yaden BC, Croy JE, Wang Y, et al. Follistatin: a novel therapeutic for the improvement of muscle regeneration. J Pharmacol Exp Ther. 2014;349(2):355-371.

2. Michel U, Albiston A, Findlay JK. Rat follistatin: gonadal and extragonadal expression and evidence for alternative splicing. Biochem Biophys Res Commun. 1990;173(1):401-407.

3. Walker RG, Poggioli T, Katsimpardi L, et al. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circulation research. 2016;118(7):1125-1142.

4. Datta-Mannan A, Yaden B, Krishnan V, Jones BE, Croy JE. An engineered human follistatin variant: insights into the pharmacokinetic and pharmocodynamic relationships of a novel molecule with broad therapeutic potential. J Pharmacol Exp Ther. 2013;344(3):616-623.

5. Shimasaki S, Koga M, Esch F, et al. Porcine follistatin gene structure supports two forms of mature follistatin produced by alternative splicing. Biochem Biophys Res Commun. 1988;152(2):717-723.

6. Tsuchida K. Myostatin inhibition by a follistatin-derived peptide ameliorates the pathophysiology of muscular dystrophy model mice. Acta Myol. 2008;27:14-18.

7. Fumagalli M, Musso T, Vermi W, et al. Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin. Experimental dermatology. 2007;16(7):600-610.

8. de Kretser DM, O'Hehir RE, Hardy CL, Hedger MP. The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair. Molecular and cellular endocrinology. 2012;359(1-2):101-106.

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Follistatin 344 (or FS-344) acts as a precursor to the protein follistatin when administered to animals as a laboratory-grade peptide. Mature follistatin regulates the release of follicle-stimulating hormone (FSH) through the inhibition of activin 1.

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Ac-Nle-Asp-His-Arg-Trp-d-Phe-Lys-NH2

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C50H69N15O9

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1024.2

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lyophilized White Powder

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Chemical Synthesis

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His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2

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C47H58N12O6

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His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

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C46H56N12O6

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873.01

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lyophilized White Powder

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Chemical Synthesis

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GHRP-6 (growth hormone releasing peptide 6) is a synthetic compound made of six amino acids. It can elicit the release of growth hormone (GH)1. Early work on GHRP-6 and similar peptides indicated that they have no structural similarity to growth hormone releasing hormone, however2. There are two analogs of GHRP-6; GHRP-6 peptide and [D-Lys-3]-GHRP-6. [D-Lys-3]-GHRP-6 has an antagonist effect on the GH secretagogue receptor (GHS-R), or the receptor for ghrelin3. Therefore, such a peptide may be used in animal studies that assess the role of this important biomolecule in various processes related to hunger and metabolic regulation. For example, ghrelin may have a role in enhancing the release of insulin in response to food intake, through the release of GLP-1 from specialized cells in the intestine4. [D-Lys-3]-GHRP-6 has demonstrated the ability to counteract this effect4. It may also be used to determine the locations of the GHS-R, e.g. in the ventral tegmental area of the brain3. [D-Lys-3]-GHRP-6 has demonstrated the ability to reduce the extent of DNA synthesis in the gastric glands of infant rats, indicating a role for ghrelin in the development of the stomach after birth5.

The GHRP-6 peptide, on the other hand, has a dose-dependent agonist effect on the GHS receptor6. However, it appears not to match ghrelin in terms of specificity6. GHRP-6 has demonstrated positive effects on organ growth and regeneration in various studies. Its administration resulted in a threefold increase in the migration, but not proliferation, of rat-intestine epithelial cells, indicating a role for the peptide in restoring gut function7. Intraperitoneal GHRP-6 peptide (at a concentration of 120 μg/kg) also significantly inhibited the effects of an animal model of multiple organ damage (i.e. ischemia-reperfusion injury)7. A combination of GHRP-6 and recombinant human epidermal growth factor (administered at concentrations of either 100 or 600 μg per kg) had a significantly detrimental effects on the neurological damage expected as a result of experimentally-induced ischemic stroke in gerbils8.

References: 1. Pimentel-Filho FR, Ramos-Dias JC, Ninno FB, Facanha CF, Liberman B, Lengyel AM. Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism. Clinical endocrinology. 1997;46(3):295-300. 2. Ghigo E, Arvat E, Muccioli G, Camanni F. Growth hormone-releasing peptides. European journal of endocrinology / European Federation of Endocrine Societies. 1997;136(5):445-460. 3. St-Onge V, Watts A, Abizaid A. Ghrelin enhances cue-induced bar pressing for high fat food. Hormones and behavior. 2015;78:141-149. 4. Gagnon J, Baggio LL, Drucker DJ, Brubaker PL. Ghrelin Is a Novel Regulator of GLP-1 Secretion. Diabetes. 2015;64(5):1513-1521. 5. Bittar NM, Zulian JG, Ogias D, Gama P. Ghrelin and GHS-R in the rat gastric mucosa: Are they involved in regulation of growth during early weaning? Nutrition (Burbank, Los Angeles County, Calif.). 2016;32(1):101-107. 6. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-660. 7. Cibrian D, Ajamieh H, Berlanga J, et al. Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure. Clinical science (London, England : 1979). 2006;110(5):563-573. 8. Subiros N, Perez-Saad HM, Berlanga JA, et al. Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy. Neurological research. 2015:1743132815y0000000089.

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H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH

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C62H98N16O22

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Lyophilized BPC 157 is Stable at room
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T3 (liothyronine) 100 mcg per ml x 30ml | Blue Sky Peptide

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T3 (liothyronine) 100 mcg per ml x 30ml | Blue Sky Peptide

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T3 (Liothyronine Sodium) is a synthetic form of triidothyronine (or T3). T3 is a thyroid hormone with many physiological functions. Buy 30ml vile of high quality T3 (liothyronine) at an economical price of only $32.95 from Blue Sky Peptide.

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Buy 1 Get 1 Free IPAMORELIN

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With Purchase over $99 | USA ONLY

Buy 1 Get 1 Free IPAMORELIN 2000mcg :

Unit Size

2 mg/vial

Unit Quantity

1 vial

Purity (HPLC)

98.21%

Sequence

H-Aib-His-D-2-Nal-D-Phe-Lys-Ile-NH2

Molecular Formula

C38H49N9O5

Molecular Weight

711.86

Appearance

lyophilized White Powder

Source

Chemical Synthesis

Storage

Lyophilized IPAMORELIN is Stable at room
Temperature for 90 days, however it is best to store in a freezer
below - 8c for any extended
period of time. After reconstitution IPAMORELIN should be
refrigerated at temperatures not to exceed 35 F.

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

Free Priority Shipping

With Purchase over $99 | USA ONLY

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Pramipexole 2mg per ml x 30ml | Blue Sky Peptide

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Pramipexole 2mg per ml x 30ml | Blue Sky Peptide

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Research Grade Pramipexole

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Buy Pramipexole :

Unit Size

60mg/ bottle

Unit Quantity

1 bottle

Application

Molecular Formula

C10H17N3S

Molecular Weight

211.33

Appearance

Clear

Physical State

Liquid

Storage

Room Temperature

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

Free Priority Shipping

With Purchase over $99 | USA ONLY

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JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser. Research Grade Pramipexole Free Priority Shipping With Purchase over $99 | USA ONLY Unit Size 60mg/ bottle Unit Quantity 1 bottle Application Molecular Formula C10H17N3S Molecular Weight 211.33 Appearance Clear Physical State Liquid Storage Room Temperature Terms The products we offer are intended for laboratory research use only.

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buy peptides and research liquids online

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Sermorelin Acetate, also known as GRF 1-29, is a Growth Hormone Releasing Hormone (GHRH) produced by the brain that stimulates the production and release of Growth Hormone (GH).

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CJC-1295 NO-DAC 5mg (MOD GRF 1-29) | Blue Sky Peptide

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CJC-1295 NO-DAC 5mg (MOD GRF 1-29) | Blue Sky Peptide

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buy peptides and research liquids online

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Modified Growth Releasing Factor aminos 1-29, usually referred to as Modified GRF (1-29) or "ModGRF(1-29)," also known as CJC-1295 without DAC, is a synthetic analog of the endogenous peptide signaling hormone Growth Hormone Releasing Hormone (GHRH).

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Epithalon Peptide 10mg - Blue Sky Peptide

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Epithalon Peptide 10mg - Blue Sky Peptide

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Free Priority Shipping

With Purchase over $99 | USA ONLY

Buy Epithalon 10mg:

Unit Size

10 mg/ vial

Unit Quantity

1 vial

Purity (HPLC)

98.11%

Sequence

H-Ala-Glu-Asp-Gly-OH

Molecular Formula

C14H22N4O9

Molecular Weight

390.35

Appearance

lyophilized White Powder

Source

Chemical Synthesis

Storage

Epithalon 10mg is Stable at room
Temperature for 90 days, however it is best to store
in a freezer below - 8c for any extended
period of time. After reconstitution Epithalon 10mg should be
refrigerated at temperatures not to exceed 35 F.

Terms

The products we offer are intended for laboratory
research use only. Please familiarize yourself with
our terms of service prior to ordering.

Click here to read more about Epithalon Peptide on our research blog

Download Epithalon HPLC Report

Download Epithalon Mass Spectrum Report

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With Purchase over $99 | USA ONLY

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Buy Bulk HEXARELIN 2mg (Save Up to 82%) - Blue Sky Peptide

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Buy Bulk HEXARELIN 2mg (Save Up to 82%) - Blue Sky Peptide

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Buy 30 for $8.33 each and save 76%

Buy 50 for $7.14 each and save 80%

Buy 100 for $6.25 each and save 82%

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Buy Bulk HEXARELIN 2mg (No Promo Codes)

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With Purchase over $99 | USA ONLY

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