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Various research teams around the world have developed tumor killing particles that consist of drug ferrying vessels and antibodies. The vessels protect the drug cargo within, while the antibodies serve as homing mechanisms to deliver the medication precisely where it's needed. While many of these approaches have demonstrated some effectiveness, the problem is that the chemical bindings between cargo vessels and antibodies lower the antibodies' abilities to find their targets and the bindings themselves lead to proteins building up on the nanocarriers, reducing their effectiveness.

To overcome these problems, researchers at Mainz University Medical Center and the Max Planck Institute for Polymer Research have come up with a physical, or non-chemical, method of connecting antibodies to drug ferrying nanoparticles. "Up to now, we have always had to use elaborate chemical methods to bind these antibodies to nanocapsules," explained Professor Volker Mailänder of University Medical Center of Johannes Gutenberg University Mainz. "We have now been able to show that all that you need to do is to combine antibodies and nanocapsules together in an acidified solution."

The new technique, which involves putting the two components within an acid solution, works through adsorption, or physical adhesion. It is much safer on the antibodies, allowing them to function nearly as they would on their own, while keeping the nanoferrying particles stable and effective at delivering the drugs within.

Here's an animation demonstrating the workings of the new approach:

Study in Nature Nanotechnology: Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona...

Via: Mainz University Medical Center...

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Physical Binding Improves Tumor Targeting Nanoparticles |

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Various research teams around the world have developed tumor killing particles that consist of drug ferrying vessels and antibodies. The vessels protect the drug cargo within, while the antibodies serve as homing mechanisms to deliver the medication precisely where it's needed.

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Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research (MPI-P) have developed a new method to attack tumors using improved nanocarrier technology.  The nanocarrier is combined with antibodies under acidic conditions to allow it to dock on immune cells, which in turn attack tumors.

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Mit dem Nano-U-Boot gegen Kopfschmerzen & Tumore

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Nanoparticle drug delivery in cancer therapy

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https://www.nature.com/articles/s41565-018-0171-6.epdf?no_publisher_access=1&r3_referer=nature

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Physical binding in an acidic environment decreases protein congestion and improves binding capability (Tonigold et al., 2018).

Previously used complex chemical processes have been simplified with the discovery of acidic environment antibody coupling (Tonigold et al., 2018).

The improved nanoparticles increase delivery to target tissue (Tonigold et al., 2018).

Proven to be twice as efficient as chemical bonding in a test tube (Tonigold et al., 2018).

Improves efficiency and applicability of therapy methods (Tonigold et al., 2018).

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Without physical binding protein congestion impairs binding sites (Tonigold et al., 2018).

Chemically coupled antibodies almost completely lose their efficacy (Tonigold et al., 2018).

Standard method of binding antibodies using complex chemical processes can degrade and destroy antibodies (Tonigold et al., 2018).

Chemically coupling antibodies is a tedious process and takes longer to complete (Tonigold et al., 2018).

Older methods were unstable when introduced into the blood (Tonigold et al., 2018).

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Nanotechnology & NanoMedicine | Andrew Hessel | Exponential Medicine 2015

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By physically binding antigens in an acidic environment, the nanoparticles are more effective at reaching target tissue.  This method decreases protein congestion and improves binding capability.  The process of physical binding is less time consuming and an easier process than chemical coupling.  This new technique has shown to be twice as efficient as previous methods.  Tonigold et al. (2018) reported, "Once the nanocarrier is exposed to biological fluid such as plasma, however, its surface is inevitably covered with various biomolecules forming the protein corona, which masks the targeting ability of the nanoparticle" (p. 60).  I feel this method should be adopted by our facility to improve patient outcomes by enhancing tissue delivery.  Tonigold et al. (2018) reported, "We conclude that pre-adsorption is potentially a versatile, efficient and rapid method of attaching targeting moieties to the surface of nanocarriers (p. 60).

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The following team members were selected after careful evaluation of the critical elements needed for completion of this project.

Rachel

Restorative - People strong in the Restorative theme are adept at dealing with problems. They are good at figuring out what is wrong and resolving it.  I chose Rachel because she is a problem solver, troubleshooter, and finds improvements and solutions that will be needed during nanotechnology integration.

Louis

Learner - People strong in the Learner theme have a great desire to learn and want to continuously improve. In particular, the process of learning, rather than the outcome, excites them.  Louis was added to the team because he is always learning, catches on quickly, and is interested in many things.  He will likely give valuable insight from a different perspective.

Randall

Responsibility - People strong in the Responsibility theme take psychological ownership of what they say they will do. They are committed to stable values such as honesty and loyalty.  I chose Randall  because he is committed, accountable, independent, trusted, and conscientious.  He will be a dependable source during implementation.

Chelsea

Command - People strong in the Command theme have presence. They can take control of a situation and make decisions.  I selected Chelsea  because she is charismatic, direct, driven, inspirational, easy to follow, clear, and concise.  She will provide positive energy and influence among group members.

Carter

Communication -  People strong in the Communication theme generally find it easy to put their thoughts into words. They are good conversationalists and presenters.  Carter was added to the team because of his great presence, he is easy to talk to, is an energizer, entertaining, and charismatic.  Communication is crucial during any major project.

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Tonigold, M., Simon, J., Estupiñán, D., Kokkinopoulou, M., Reinholz, J., Kintzel, U., . . . Mailänder, V. (2018). Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona. Nature Nanotechnology, 60-73. doi: https://doi.org/10.1038/s41565-018-0171-6