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Helena Gutierrez, M.D. - Pediatrics | UAB; Pediatric Gastroenterology and Pediatric Transplant Hepatology

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Assistant Professor

Division of Pediatric Gastroenterology, Hepatology & Nutrition

Education

Medical School
St. George's University
Residency
SUNY Upstate Medical University
Fellowship
Pediatric Gastroenterology, Hepatology and Nutrition
Mayo Clinic
Pediatric Transplant Hepatology
Children's Hospital of Los Angeles

Interests

Liver transplant, acute liver failure, autoimmune hepatitis and non-alcoholic fatty liver disease.

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Helena Gutierrez, M.D. - Pediatrics | UAB

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Assistant Professor Division of Pediatric Gastroenterology, Hepatology & Nutrition Education Medical School St. George's University Residency SUNY Upstate Medical University Fellowship Pediatric Gastroenterology, Hepatology and Nutrition Mayo Clinic Pediatric Transplant Hepatology Children's Hospital of Los Angeles Interests Liver transplant, acute liver failure, autoimmune hepatitis and non-alcoholic fatty liver disease.

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"A Case Series of Children with Acute Hepatits and Human Adenovirus Infection" A spike in cases of children testing positive with hepatitis and human adenovirus viremia was observed in 2021-2022. A study conducted indicated that out of 15 children examined, 89% with hepatitis of unknown etiology tested positive for adenovirus. Whether human adenovirus was the causative agent of hepatitis is still under investigation.
https://pubmed.ncbi.nlm.nih.gov/35830653/

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Researchers Focus On Adenovirus In Global Surge Of Hepatitis Cases

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https://baodanang.vn/english/infographics/202209/how-to-detect-and-prevent-adenovirus-in-children-3923366/

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1. PREVENTION - wash hands frequently with soap and water for at least 20 second; avoid close contact with infected individuals; avoid touching areas where the virus can enter the body (eyes, nose, and mouth).
2. VACCINATION - vaccinations are only available to military persons at this time. Safety and effictiveness of the on immunosuppressed individuals is unknown.
3. PROTECT OTHERS - sick individulas should remain home and avoid close contact with others, wash hands often, and cover their cough or sneeze with a tissue to lower transmission.
https://www.cdc.gov/adenovirus/about/prevention-treatment.html

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Diagnosis - there are a variety of tests including antigen detection, polymerase chain reaction (PCR), virus isolation and serolgy.
Treatment - there is no antivral that is FDA-approved to treat adenovirus. Most infections can be cared for with over-the-counter medications to treat symptoms, rest, and plenty of fluids.
1. Cidofovir is not currently approved FDA-approved but has been used in individuals that are immunocompromised to treat the virus in severe cases.
https://www.cdc.gov/adenovirus/hcp/prevention-treatment.html

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1. Fever
2. Sore throat
3. Common cold and flu-like symptoms
4. Diarrhea
5. Pneumonia (in severe cases)

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Adenoviruses can cause mild to severe illness, though serious illness is less common. People with weakened immune systems, or existing respiratory or cardiac disease, are at higher risk of developing severe illness from an adenovirus infection.

Adenoviruses can cause a wide range of illnesses such as

common cold or flu-like symptoms

fever

sore throat

acute bronchitis (inflammation of the airways of the lungs, sometimes called a "chest cold")

pneumonia (infection of the lungs)

pink eye (conjunctivitis)

acute gastroenteritis (inflammation of the stomach or intestines causing diarrhea, vomiting, nausea and stomach pain)

Less common symptoms of adenovirus infection include

bladder inflammation or infection

neurologic disease (conditions that affect the brain and spinal cord)

Learn more about adenoviruses

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Adenoviruses can cause mild to severe illness, though serious illness is less common. People with weakened immune systems, or existing respiratory or cardiac disease, are at higher risk of developing severe illness from an adenovirus infection.

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These double-stranded DNA viruses are medium-sized (90-100 nm), non-enveloped (lacking an outer lipid bilayer), and have a striking icosohedral protein shell.

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Adenoviridae

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Adenoviruses (Adenoviridae) are a group of viruses that cause a wide range of illnesses that can affect the respiratory, gastrointestinal, or genitourinary systems in vertebrates. The virus can enter the body through the eyes, mouth, or nose and can be spread through close personal contact with an infected person, travel in airborne droplets, and through contac with a contaminated object.
https://en.wikipedia.org/wiki/Adenoviridae

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Describes adenoviruses, who is at risk, symptoms, how it spreads