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With my new pain reliever, we’d have to observe both positive and negative effects. We’d have to look for responses that show no effect, positive effects, and how much of a dose is too much before it turns lethal.

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Responses that were acute were from higher doses showed effects of paint relief fast but at an alarming and possibly lethal rate. Those who took lower doses received a chronic response. The effects were coming at a slow but manageable rate.

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The criteria I would use to determine whether or not my drug is safe is both the efficiency and the lethality of dosage. Of course we want the rate of the effects to be chronic but we don’t want the effects to kick in too slowly, we’d want it to come at a reasonable pace.