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patient.info 3/4
Had a decent amount of ad, sounded a little biased.

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webMD 3/4
had great information but there were ads that didn't correlate to the subject

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medicinenet 4/4
had really good info the ads were directing you to more of the same general content. journalized base

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government website. its credible, and not controversial. it tells you what you need to know about antacids

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Continuing Education Activity

Antacids are a group of drugs that have been on the market for many years. They were initially first-line defense against peptic ulcer disease; however, the discovery of proton pump inhibitors revolutionized the treatment of peptic ulcer disease. Currently, antacid use is restricted for the relief of mild intermittent gastroesophageal reflux disease (GERD) associated heartburn. This activity reviews the indications, contraindications, pharmaceutical action, adverse events, and other key elements of antacid therapy in the clinical setting as relates to the essential points needed by members of an interprofessional team managing the care of patients with heartburn and mild GERD.
Objectives:

Identify the mechanism of action antacids.

Summarize the indications for antacid therapy, as well as relevant interactions with other medications.

Review the contraindications and adverse events associated with the use of antacids.

Outline the role of interprofessional coordination in guiding patient care and improving outcomes when using antacid therapy.

Earn continuing education credits (CME/CE) on this topic.
Indications

Antacids are a group of drugs that have been on the market for many years. They were initially first-line defense against peptic ulcer disease; however, the discovery of proton pump inhibitors revolutionized the treatment of peptic ulcer disease. Currently, antacid use is restricted to the relief of mild intermittent gastroesophageal reflux disease (GERD) associated heartburn.[1] The estimated prevalence of heartburn at least once per week in North America ranges from 18% to 28%, with 25% adults reporting heartburn daily.[2][3][4][5]

Antacids are medications that do not require a prescription; in other words, they are self-prescribed. Antacids are a combination of various compounds with various salts of calcium, magnesium, and aluminum as the active ingredients. The antacids act by neutralizing the acid in the stomach and by inhibiting pepsin, which is a proteolytic enzyme. Each of these cationic salts has a characteristic pharmacological property that determines its clinical use. Antacids have therapeutic use for the following[6]:

Mechanism of Action

The antacids reduce the acid reaching the duodenum by neutralizing the acid present in the stomach. The main objectives are:
Aluminum Hydroxide
The salts' mechanism of neutralization of acid varies, and each salt has a different mechanism with the ultimate goal of acid neutralization.

The formulation of aluminum hydrochloride and water results in the neutralization of the acid in the stomach. It is also known to inhibit pepsin activity.[7] Aluminum hydroxide is complexed with a sulfated polysaccharide sucrose octasulfate to form sucralfate. This complex does not have a significant buffering action against the acid or has no effect on the pepsin secretion and does not alter the gastric acid production in any way.[8][9] Nevertheless, it is known to heal chronic ulcers and prevent acute mucosal damage induced chemically by reducing access to pepsin and acid. Sucralfate, like its aluminum hydroxide component, is known to stimulate angiogenesis and granulation tissue formation.[8]
Calcium Salts
Aluminum hydroxide is also useful in hyperphosphatemia due to its ability to bind phosphate in the gastrointestinal (GI) tract and subsequently prevent the absorption of phosphate.[10]

Calcium salts neutralize gastric acidity resulting in increased gastric and duodenal bulb pH; they additionally inhibit the proteolytic activity of pepsin if the pH is greater than 4 and increase lower esophageal sphincter tone. The calcium released from calcium carbonate is known to increase peristalsis in the esophagus, pushing the acid into the stomach and provide relief from symptoms of heartburn. The calcium salts also form combined insoluble compounds with dietary phosphate and prevent the absorption of later.[11]

The acid-neutralizing mechanism of the antacids is well understood, as mentioned above. In addition to this, other mechanisms add to the ulcer healing properties of this class of drugs. The exact mechanism is still unclear, but it is believed to be a combination of[12][7]:

Administration
Aluminum Hydroxide (Antacid)

Oral: Usually taken daily after meals and at bedtime at a dose of 640 mg up to 5 to 6 times a day with a maximum dose of 3840 mg per 24 hours.

Suspension The dose for suspension form is 320 mg/5 mL (473 mL). The suspension is to be shaken before use and is to be followed by water.

Hyperphosphatemia

Oral: Use is reserved for patients with serum phosphorus levels greater than 7 mg/dl.It is to be taken with meals at a dose of 300 to 600 mg three times a day, with use limited to a short period (4 weeks).[13]

Calcium Carbonate (Antacid)
The dose for antacids depends upon the age of the patient, the purpose of administration (neutralization of acid or off-label use), and the presence of other comorbidities like renal or hepatic impairment. As all the forms of these medications are available as over the counter medication, the dosing recommendation varies by product/and or manufacturer.
Hyperphosphatemia
It is used up to a maximum dose of 8000 mg per day up to 2 weeks with 1 to 4 tablets for symptomatic relief.
Pregnancy and Breastfeeding
The total dose is not to exceed 2000 mg per day.[13]

Antacids containing aluminum salts are safe to be used in pregnant women as well as for women during labor for aspiration prophylaxis. The information regarding the use of aluminum-containing antacids in breastfeeding females has not been studied, but aluminum is known to be endogenous to breast milk.[14][15] In the case of calcium-containing antacids, excessive use is to be avoided in pregnant women as calcium crosses the placenta. The amount of calcium reaching the fetus is dependent on the physiological changes in the mother. Maternal calcium intake also affects the amount of calcium excreted in breast milk; the currently prevailing opinion is that the use of calcium-containing antacids is safe during breastfeeding.[16]

Adverse Effects
Aluminum Hydroxide
Adverse effects are prominent in the infant and the elderly populations. The chronic use of antacids in this population is not a recommendation due to safety concerns.
Calcium Carbonate
Aluminum use is associated with an increased risk of toxicity in individuals with renal failure and infants. It presents as[17][18][19][20]:

The adverse reactions often seen with this group of antacids are[20][21]:

Contraindications

The absolute contraindication is hypersensitivity to any component of the formulation. Also, antacid agents require caution in patients with:

Monitoring

The average therapeutic dose of antacid is 10 to 15 mL (1 tablespoon or one package content) of liquid or 1 to 2 tablets 3 to 4 times a day. Periodic monitoring of calcium and phosphorus plasma concentrations is a suggested practice in patients on chronic therapy.

Toxicity

No information is available regarding toxicities caused by aluminum- and calcium-containing antacids. However, antacids are to be used cautiously in the high-risk population mentioned above.

Enhancing Healthcare Team Outcomes

Antacids are available as over the counter medications, meaning that patients do not require a prescription to obtain them. This situation results in the improper use of these medications with little to no relief of symptoms. There is a need to educate patients regarding the importance of a correct mode of administration, time of administration, and dosage for the prompt and prolonged relief of symptoms. These medications only provide symptomatic relief, which may mask an underlying disorder, but lack of awareness in this regard delays diagnosis in health conditions like GERD, peptic ulcer, gastric ulcer, and hiatal hernia. Although these medications do not cause toxicities in high doses, it is imperative to understand their interaction with other medicines, especially in patients on polypharmacy.

Nursing can verify drug use on intake and at each exam, and report to the treating physician. Pharmacists will encounter patients in the retail pharmacy and can counsel and educate patients on the advantages and pitfalls of antacid therapy and inform the patient's treating physician if there any issues (drug-drug interactions, for example). Even a medication as apparently benign as OTC antacids can have significant effects on patient health, and the interprofessional team needs to work together and communicate to achieve positive outcomes. [Level V]

Continuing Education / Review Questions

References

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Antacids are a group of drugs that have been on the market for many years. They were initially first-line defense against peptic ulcer disease; however, the discovery of proton pump inhibitors revolutionized the treatment of peptic ulcer disease. Currently, antacid use is restricted for the relief of mild intermittent gastroesophageal reflux disease (GERD) associated heartburn.

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- Can affect the balance of your calcium level
- Damage of kidneys
- Too much calcium can cause nausea
- If antacids have aluminum, it may cause constipation
- Diarrhea
- Metabolism changes

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(if uses way too much)

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- Antacids help treat heartburn (indigestion)
- Makes acids in stomach less corrosive
- Over the counter drug (no prescription needed)
- Reduce the acid reflux that causes heartburn

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Helps neutralize the acids in the stomach, and alleviates pain

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neutralize the acids in your stomach that erupt, and helps alleviate pain