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(Osimertinib) is prescribed to treat metastatic non-small cell lung cancer in patients with T790M mutation in the epidermal growth factor receptor (EGFR) gene, who developed progressive disease during and after EGFR tyrosine kinase inhibitor therapy. The medication can be prescribed only after the mutation has been confirmed by the laboratory tests.

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通用名称：吉非替尼片
英文名称：Gefitinib Tablets
汉语拼音：Ji Fei Ti Ni Pian
[成分]
本品主要成份为吉非替尼, 其化学名称为：N-(3-氯-4-氟苯基)-7-甲氧基-6-(3-吗啉丙氧基)喹唑啉-4-胺
其结构式为：

分子式：C22H24ClFN4O3
分子量：446.90

[适应症]
本品适用于治疗既往接受过化学治疗的局部晚期或转移性非小细胞肺癌(NSCLC)。既往化学治疗主要是指铂剂和多西紫杉醇治疗。
对于既往化学治疗失败的局部晚期或转移性非小细胞肺癌患者的疗效，是基于客观反应率指标而确立的，尚无对照性的研究显示改善疾病相关症状和延长生存期方面的临床受益。本品用于非小细胞肺癌二线治疗的现有数据仅基于非对照的临床研究，尚待设计良好的对照的临床试验进一步证实。
对于非小细胞肺癌的一线治疗，两个大型的随机对照临床试验结果表明: 基于铂剂的二联化疗方案合用本品治疗后未显示任何受益，因此，吉非替尼不适用于此种治疗。
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Patients with advanced non-small-cell lung cancer (NSCLC) have a poor prognosis and suffer many disease-related symptoms. Treatments should therefore aim to palliate these symptoms as well as improve overall quality of life. Gefitinib (‘Gefitinib’) is a novel epidermal growth factor receptor tyrosine kinase inhibitor that targets cell signaling involved in tumor growth and differentiation. Gefitinib provides objective responses and symptom relief, and was generally well tolerated.

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Cipla Gefitinib Tablets Details:

Brand Name : Gefticip
Active Ingredients : Gefitinib I.P
Manufactured by : Cipla Limited
Strength: 250 mg
Form: Tablets
Packing: Pack of 30 Tablets

WHAT IS GEFTICIP ?

Gefticip is a type of drug called a tyrosine kinase inhibitor (TKI), also known as a cancer growth inhibitor. Kinases are proteins in the body that regulate how the cells grow and divide. Gefticip blocks (inhibits) the protein from sending signals to the cancer cells that make them grow and divide.

USES

Gefticip is used to treat some people with non-small cell lung cancer (NSCLC). It only works for cancers that have an abnormal form of a protein called epidermal growth factor receptor (EGFR). Tests are done on the cancer cells from a lung biopsy or previous surgery to check the level of EGFR.

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