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- everything about leptospira interrogan including mode transmission, etiology agent , microbiology🦉fatiha
- Leptospirosis types, ecteric, anecteric, another one i dont hear.⚽ (PRAVEI)
- Pathogenesis leptospirosis🌅 Iman Imanicebear
- Pathophysiology (chief complaint only)👩‍⚕ (SINEHAA)
- Serology; microscopic agglutination test(confirmation test MAT) 🙈 Nafiz
- Zoonosis ddx -  all etilogy agent, mode transmission
i) general other 3-4 zoonosis example.🤥 (OMAR)
Next 4 will be detailed,😶‍🌫😶‍🌫 symptoms n so on
ii) brucella
iii) rabies
iv) influenza
v) nipah virus

MERCI - Pharmaco in tx leptospirosis, psychosocial implication, relate possible prognosis and complication 🧑‍⚕jim

LEARNING OUTCOME
LO1 Relate the pathogenesis and pathophysiology of leptospirosis diseases to its clinical presentation

LO2 Apply the knowledge of microbiology and serology to interpret investigations results of leptospirosis

LO3 Apply the knowledge of pharmacology in the treatment for leptospirosis

LO4 Discuss the psychosocial implications of leptospirosis disease

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Pathogenesis of Pathophysiology of leptospirosis
Microbiological of leptospirosis
Pharmacology n treatment of leptospirosis
Zoonosis (general, aetological agent, host) ;
Brucella, Rabies, Influenza, Nipah virus
MERCI
Serology - Microscopic Agglutination Test (MAT) - confirmatory test

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Merci
Management on the patient, antibiotic leptospirosis.

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Na normal
K normal
Urea high
Creatinine high
Kidney unable to filtered out the urea n creatinine. AKI indication

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Direct(Conjugated bilirubin), hyperbilirubinemia, hepatic jaundice

AST HEPATOCYTE DAMAGE
ALT ALSO SAME
ALP HEPTIC OBSTRUCTION

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FBC
HB LOW( Pathogen damage vessel and virus lead to rbc lysis)
Platelet( reduced may because of BM suppression, or utilize in inner haemorrhage)
DVT only in thrombocytosis
Twbc: elevated ( infection trigger inflammation)

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Endo
CNS
GI
GU

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Dehydration (fever lead to moist waste out ), renal fx test check for AKI
Jaundice n Hepatomegaly - Hepatic jaundice. Liver damage, check also personal hx alcoholic or primary from infection.
High grade fever,
tachycardia, compensatory tacycardia as bp low because of dehydration.

tachpnea, hypoxia cell, stimulate increase of respiratory rate

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Teenage 20 yrs, college student, hv competent immune system except if he hv other medical problems

Inexperienced or not know on prevention in jungle esp hygiene

CC=
Fever(lasted 2 weeks, prolonged fever)= any drug history to relieve the fever?
redness of the eyes(diagnostic symptoms), CVS, vasodilation secondary to infection, why happen at the eyes occular vascular involvement?
headache - do all fever come with headache or mainly involve cns inflammation? Meningitis, Encephalitis
calf pain - what type of pain characteristics, usually happen fr people with jungle trekking prolong to 4 weeks, still varies to the the person ability.
DVT

-muscle damage after incubation period happen acutely

Risk factor
Jungle trekking,
wild boar presented (zootopic infection) ddx,
, friend with same complaint

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Fareed, a 20-year-old college student presented with fever, redness of the eyes, headache and calf pain for two weeks.
He went for jungle trekking three weeks prior to the presentation. Five other participants had been admitted due to the same complaints. They noted there was an evidence of wild boar presence in the area.

On examination, he was dehydrated and jaundiced. His temperature was 39.2oC, blood pressure was 90/50 mmHg, pulse rate was 110 beats/min and respiratory rate was 24 breath/min. Abdominal examination revealed palpable liver, 3 cm below costal margin. Other systems were normal.