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Huntington's disease is the result of a defective gene. It involves a genetic defect on chromosome 4. It causes a part of DNA to occur more than usual. A person only needs one copy of the defective gene to develop the disorder. In rare cases, Huntington's disease can be caused by a mutation in the HTT gene. It can occur for the first time in an affected person and isn't inherited through the parents in this case. The mutation passes through generations and the size of the mutation increases.

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By Miguel Hernandez

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Huntington's disease can cause problems in the muscles of people who inherit this. Problems like loss of muscle and muscle spasms can lead to problems in walking, coordination, and involuntary movements. This disease can also lead to delusions, amnesia, slowness in mental activity, mental confusion, and trouble with concentrating. People with this disease also have behavioral issues like fidgeting and irritability. They also suffer from depression, paranoia, and hallucinations. Many have anxiety and mood swings and suffer from tremors, weight loss, and impaired voice.

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There is no cure for Huntington's disease, but there are therapies to treat it. Counseling can help victims of this disease get advice and support to help make decisions and change their behavior. Physical therapy can also help in regaining muscle function and strength. Other treatments can help nervous system and mental disorders and give drugs to help treat the disease.

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NHS VIDEOS | Huntington's disease - Health videos - NHS Choices

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Get expert advice on Huntington's disease and watch Lee talk about the importance of getting tested if you have a family history of it.

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https://www.mayoclinic.org/diseases-conditions/huntingtons-disease/symptoms-causes/syc-20356117

https://medlineplus.gov/huntingtonsdisease.html

https://rarediseases.org/rare-diseases/huntingtons-disease/

https://ghr.nlm.nih.gov/condition/huntington-disease

https://www.huntingtonsnsw.org.au/information/hd-facts/causes