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As a woman in STEM, Isadore is inherently defiant of traditional jobs for women. According to AAUW, women make up 28% of the workforce in STEM fields.

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Isobel is a very messy thinker, with her scrapbook being difficult to understand unless you know what you're looking for. 

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Dionisio's mental illness makes him incapable of understanding normal social situations and, as such, he can't offer much insight to our main character.

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Dionisio's capacity for extreme violence is another form of alterity. His ability to move on so easily from the murder he committed is strange to say the least.

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He's rich! He's able to do his weird little science on this subject which doesn't actually exist in order to feed his mental illness. 

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He is very socially awkward, unable to interpret sexual advances or emotional connection with others. 