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Fetus- child = very sensitive

mature Ova = least sensitive at ages 20-30 yrs

Irregular mensuration occurs at .1 Gy

Temporary sterility = 2Gy w/ a recovery period of several weeks

Permanent sterility occurs at a single dose of 5 Gy

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Don't divide, highly specialized movement functions = radioresistant

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Immature embryo-fetus =  radiosensitive

maximum window of sensitivity = 8-15 weeks following gestation

Sensitivity levels drop after the 25th week, sensitivity considered = to adults

Adult nerve cells are highly & non-dividing specialized = insensitive

Damage to the dendrites or axon results in impaired function

Dose > than 50 Gy delivered to the nucleus causes cell death

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Devoid of blood vessels

Constantly regenerated through mitosis

50% renewal of Intestinal lining occurs each day

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Immature = highly radiosensitive

Mature = relatively insensitive

1 Gy dose decreases sperm count & creates the potential for genetic mutations

2 Gy dose temporary sterility for up to 12 months

5-6 Gy dose = Permanent sterility

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Longest life span of blood cells, making them the least radiosensitive (120 days)

Once irradiated, the decrease in numbers may not be apparent for weeks

Recovery takes months

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0.5 Gy decreases these numbers

Slow recover -can be up to 2 months

Thrombocytes have a life span of 30 days

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Live for less than 1 week

After exposure they increase in #, then rapidly drop, then slower drop in #

Recovery is about 2 months

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Live for 24 hours, making them highly radiosensitive

0.25 Gy decreases the count while 0.5-1.0 Gy drops the count to 0

At lower levels of Gy, the blood cell recovers shortly after irradiation, higher doses requires several months for recovery

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Most

Least

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Includes spermatogonia and ova

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Includes the lining of GI tract, respiratory tract, and blood vessels as well as the skin on outside of body

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Includes bone marrow, circulating blood, and lymph tissue

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               Inversely proportional to age

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               Inversely proportional to age

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As cells age and become more mature their susceptibility to damaged caused by ionizing radiation lessens.

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      Inversely proportional to degree of differentiation

# data[].attributes.subject
      Inversely proportional to degree of differentiation

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The more specialized a cell is, the more sensitive it will be to ionizing radiation. Therefore the relationship between degree of differentiation and dose is an inverse one.

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    Directly proportional to reproductive activity

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    Directly proportional to reproductive activity

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The relationship shared between reproductive activity and radiosensitive is a liner one. A cell of frequent reproductive activity is more vulnerable to ionizing radiation sensitivity.

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                  Function of metabolic state

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                  Function of metabolic state

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High metabolism = radiosensitive