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Anti-CD3 til inhibering af T-celle aktivering.
(Muromomab)
Anti-IL-2R til reduktion af T-celle aktivering.
(Daclizumab og Basilioximab)

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I nogle celletyper (t celler) inhibere den NF-kappaB aktivering

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- Er derivater af glukocorticoider
- Kan krydse cellemembraner og binde intracellulære receptorer
- De aktiverede receptorer transporteres ind i cellekernen, hvor de binder til DNA og interagerer med andre transkriptionsfaktorer
- Stimulerer udtrykket af en inhibitor for phospholipase A2 --> hæmmer dannelsen af proinflammatoriske prostaglandiner og leukotriner
- Kan hæmme udtrykket af proinflammatoriske cytokoiner
- Hæmmer produktionen af NO
- Inhiberer inflammatorisk cellemigration ved at hæmme udtrykket af adhæsionsmolekyler

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Glædelig jul

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Anti-inflammatoriske drugs som ændrer transskriptionen af en række gener og mindsker dermed immunresponset

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Cyclosporin A (inhiberer calcineurin, som leder til inhibering af NFAT-signalering og derved T-celle-aktivering)
Tacrolimus/FK506 (inhiberer FKBP, hvorved mTOR inhiberes og derved celleproliferation)
Rapamycin (inhiberer FKBP, hvorved mTOR inhiberes og derved celleproliferation)

Nødvendigt for at undgå afstødning af transplanteret organ (host vs graft)

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Kortikosteroider --> et af tre slags er glukokortikoider, der har anti-inflammatorisk effekt. Kortisol er det fysiologiske glukokortikoid.

Free cortisol diffuses across cell membranes of target cells and activate the cytosolic glucocorticoid receptor (GR), which thus can translocate into the nucleus and act as a regulator of transcription by binding glucocorti-coid response elements (GRE’s) that 10% of all genes are under the control of.

Cortisol is the active glucocorticoid in humans and serves multiple purposes, although it is primarily recognized as a stress hormone. During a stress response (“fight or flight”) as well as during fasting, cortisol levels increase with an overall catabolic goal to ensure sufficient blood glucose to essential organs like the brain by promoting

gluconeogenesis and precursor formation to this process. Furthermore the active glucocorticoid has anti-inflammatory abilities e.g. by inhibiting eicosanoid biosynthesis and release of pro-inflammatory cytokines from macrophages.