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The 'DNA corrector' is more efficient in the most important regions of the genome

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The 'DNA corrector' is more efficient in the most important regions of the genome

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"Error surveillance and repair mechanisms during DNA replication do not show the same competence in all regions of the human genome. Scientists have discovered that the mechanism that repairs errors in DNA is more efficient in the regions of genes that hold information for the production of proteins."

Joan Frigola, Radhakrishnan Sabarinathan, Loris Mularoni, Ferran Muiños, Abel Gonzalez-Perez, Núria López-Bigas. Reduced mutation rate in exons due to differential mismatch repair. Nature Genetics, 2017; DOI: 10.1038/ng.3991

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The main function of DNA Polymerase is to make strands of DNA from nucleotides. DNA Polymerase does the very important job of performing a process called semi conservative replication. In this process, the enzyme complex synthesizes two new strands of DNA that are identical to the parent strand. Both strands are synthesized at the same time, the leading strand and the lagging strand. One type of DNA Polymerase moves down the leading strand in the 3' to 5' direction. The other type has to replicate the lagging strand in sections due to the fact that the strand runs in the opposite direction of the leading strand. DNA polymerase is also responsible for catching and fixing mistakes that occur during the replication process.

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DNA Polymerase is found inside of the nucleus in every cell.

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An enzyme (protein) that assembles nucleotides during DNA Replication - responsible for making a copy of the DNA parent strand. There are several types of DNA polymerases - each one of them is responsible for contributing efforts to a specific portion of semiconservative DNA replication. DNA polymerase is also an exonuclease, an enzyme that helps correct mistakes made during the replication process.