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This is said to Macbeth by Lady Macbeth after he had killed Duncan and the blood had got on Macbeth. The deed, which is meant to be blood symbolizes the murder.

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"A little water clears us of this deed"(II.ii.68).

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is a figure of speech in which a thing or concept is referred to by the name of something closely associated with that thing or concept.

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In Macbeth, blades are used frequently to kill, causing a lot of blood shed. (For example Duncan and Banquo.) Then the death that occurs plays a major part in the progression of the play.

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(Nepture)

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As Macbeth is about to murder Duncan, he sees a floating dagger in the air with blood on it. It represents the murder he’s about to commit and the guilt it will cause.

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"I see thee still, And on thy blade and dudgeon gouts of blood, Which was not so before"(II.i.45-47).

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That was said by Macbeth after he killed Duncan. He asked if Neptue (the oceans) could wash the blood off his hands. Symbolizing washing away the guilt for murdering Duncan.

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"Will all great Neptune’s ocean wash this blood. Clean from my hand? "(II.ii.-61-61).

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Lady Macbeth wants her blood to thicken so her veins clog up and she doesn’t feel remorse.

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"Make thick my blood.

Stop up the access and passage to remorse" (I.v.33-35).

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In Macbeth, blood is used to represent murder and death. What blood symbolizes changes as the play goes on, “adapting” to the atmosphere and moods of characters.

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BLOOD REPRESENTS LIFE, DEATH AND PAIN

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the red liquid that circulates in the arteries and veins of humans and other vertebrate animals, carrying oxygen to and carbon dioxide from the tissues of the body.