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Alice Eve On Her Beautifully Mismatched Eyes - CONAN on TBS

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SECTORAL HETEROCHROMIA - Half brown, half blue eyes

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https://rarediseases.info.nih.gov/diseases/8590/heterochromia-iridis
https://www.medhelp.org/posts/Eye-Care/How-does-an-eye-injury-cause-heterochromia/show/1965760
http://go.galegroup.com/ps/retrieve.do?tabID=Reference&resultListType=RESULT_LIST&searchResultsType=SingleTab&searchType=AdvancedSearchForm&currentPosition=1&docId=GALE%7CCV2642650082&docType=Topic+overview&sort=Relevance&contentSegment=&prodId=SCIC&contentSet=GALE%7CCV2642650082&searchId=R3&userGroupName=ahsmedia&inPS=true

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Congenital Syndromes are special conditions that you are born with. Examples of these are Waardenburg and Sturge-Weber Syndromes. These conditions result in a symptom of heterochromia, either complete or segmental.

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Some drugs and medications can cause pigment changes in the eye. Specifically, treatments for glaucoma can cause eyes to change color.

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Melanoma is a cancer that causes an increased pigmentation in the skin. When present in eyes, it causes the color to change.

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From Duke to Stardust, the many faces of David Bowie birthed movements in musical culture - each one different from the last. As he disappeared into the night this week, he did so far from quietly, leaving behind his final opus. Backstar is, in many ways, the mark of a new Bowie, the latest incarnation of our favorite eccentric. But at the center of the final chapter, Bowie placed a feature which many of us have come to remember him by: his eyes.

Like most everything about the man who fell to Earth, Bowie's eyes were at odds. The right, a clear blue. The left, a moody green - as if they too, hailed from different planets. Most people assume Bowie to be among the few with complete heterochromia, a rare condition by which a person (or, more commonly, a non-human animal) has different-colored irises. Chances are, you've seen this before in a husky or house cat, but if you look closely, you'll notice that Bowie's ocular anomaly was something else entirely. His eyes weren't different colors at all.

The left eye, rather, had a permanently dilated pupil, the mark of a condition known as anisocoria.

Your irises do more than lend color to your eyes. The structures consist mostly of smooth muscle, which can contract and relax to control how much light enters the pupil, like a camera's aperture. If you shine a light into your eyes, you'll see this happen - the iris contracts, the pupil closes, and as a result, you aren't blinded by the change in brightness.

Bowie's left eye, however, was unable to react in this way. As story has it, the damage was caused by friend George Underwood, who socked Bowie during an adolescent show of bravado back in 1962. Just how much of this is true, we'll never know, but trauma like this can certainly cause anisocoria if the muscles that contract the iris are damaged. In fact, the same thing happened to my uncle, as seen in the photo below.

Because the pupil is fixed in the open position, the injured eye as a whole appears much darker than the unaffected eye. This tricks your brain into perceiving the iris as being darker as well.

Underwood went on to perform countless collaborations with Bowie, who reportedly thanked his friend for the injury. Those otherworldly eyes became, like so many things along the way, a part of who David Bowie was.

"I always had a repulsive need to be something more than human," he said. "I felt very puny as a human. I thought, 'F**k that. I want to be a superhuman.'" And he was.

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The Curious Case of DAVID BOWIE's Otherworldly Eyes | Nerdist

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From Duke to Stardust, the many faces of David Bowie birthed movements in musical culture - each one different from the last. As he disappeared into the night this week, he did so far from quietly, leaving behind his final opus. Backstar is, in many ways, the mark of a new Bowie, the latest incarnation of our favorite eccentric.

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An injury to the eye can cause a loss of pigmentation, causing a lighter eye color.

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- injury
- melanoma
- medications
- congenital syndromes

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My Heterochromia Story & FAQ (aka "Why are your eyes two different colors?!") | Twinklefarts

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Eye color is caused by the amount of melanin/pigment in your iris. Drugs, age, and disease can all cause changes in iris pigment, resulting in a change of eye color.

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Eye color is controlled by more than one gene, so cannot be determined using a simple Punnett square like other, simpler, hereditary traits.

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Heterochromia iridum is a condition that affects eye color. Segmental heterochromia is when multiple colors can be seen in one iris. Complete heterochromia is when the two eyes are different colors.