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Continued stress leads to this stage, in which the body's resources are drained and the stress hormones are depleted. Some of the typical signs and symptoms include, Emotional Signs: Anxiety, apathy, irritability, mental fatigue. Behavioral Signs: Avoidance of responsibilities and relationships, extreme or self-destructive behavior, self-neglect, poor judgement. Physical Signs: Excessive worry about illness, frequent illness, exhaustion, overuse of medicine, physical ailments and complaints.

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During this stage, bodily adjustments to stress stabilize. As the body's defenses come into balance, the symptoms of the alarm reaction will disappear. On the outside, everything seems to be normal. However, the body may be able to cope with the original stressor, but its resistance to other stresses is lowered. It is during this stage that the first signs of psychosomatic disorders begin to appear.

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During this stage, your body mobilizes its resources to cope with added stress. The pituitary gland signals the adrenal gland to produce more adrenaline, nonradrenaline, and cortisol. As the stress hormones are dumped into the bloodstream, some bodily processes are speeded up and others are slowed down. This allows bodily resources to be applied where they are needed. During this first stage, people may have reactions such as a headache, fever, fatigue, sore muscles, shortness of breath, diarrhea, upset stomach, loss of appetite, and lack of energy.

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Although stress can be a major behavioral risk if it prolonged or severe, stress is not always a bad thing. Hans Selye observed that "to be totally without stress is to be dead." There is good stress and bad stress. A healthy lifestyle may include a fair amount of good stress. The stress reaction begins in the ANS. Unless a form of stress relief is found, the result will be a psychosomatic disease. When Selye examined animals in the later stages of GAS, he found that their adrenal glands were enlarged and discolored. Intense shrinking of the internal organs such as the spleen, thymus, and lymph nodes were evident and many animals had stomach ulcers. Stress can disrupt the immune system.

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The impact of long term stresses can be understood by examining the body's defense mechanisms against stress. A pattern known as General Adaptation Syndrome. GAS is a series of 3 stages of stress response to prolonged stress. Selye noticed that the body's initial reaction to any disease or trauma is almost identical. The body responds in much the same way to any stress. The 3 stages of GAS are the alarm stage, the stage of resistance, and the stage of exhaustion.