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In the film he shows us how the subject is a very talented doctor (neurosurgeon), who has ambitions and different goals, is only concerned with money and is very arrogant.

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The doctor is invited to give a talk and suffers from an accident in his car, he manages to survive but his hands end up badly damaged and he demands that they put metal needles in them. When he recovers he suffers from terrible hand tremors and his career as a doctor ends.

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He seeks to go back to work anyway, they have problems with his close relationships, then he undergoes different experimental surgeries, spending all his money and time to return to his normal life. Seeing that he did not achieve much, he looks for Jonathan Pangborn so that he can help him, he is a paraplegic who managed to return to his daily life and he tells him that he must go to Kamar-Taj to answer his call.

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When he arrives at the place he meets the supreme sorceress or the Ancestral one, she shows him her power, revealing the Astral Plane and other dimensions of the Multiverse. When she accepts the call she begins to train to recover and understand her mission.

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His teacher Wong and the sorceress explain to him how their world works and that it is protected by the so-called Sanctuaries, which are located in New York City, London and Hong Kong. Strange has to decide whether to get his hands back or help protect the world with the help of his teachers and powers.

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He learns to use the power of time with the mystical Eye of Agamotto, but Mordo and Wong who are his allies explain to him that this power is a risk and that the use of it is similar to the arrogance of his enemy Kaecilius because he believes that everyone should live as long as Ancestral after the death of their loved ones and has plans to open the dark dimension to achieve his goal.

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Kaecilius and his followers use the stolen pages to summon the mighty Dormammu from the Dark Dimension, where time does not exist and everyone can live forever. They destroy the Sanctuary of London and this act pushes Strange from Kamar-Taj to the Sanctuary of New York.

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Kaecilius and the Zealots arrive at the sanctuary in New York, and Strange stops them with the Cloak of Levitation, there he faces his first test of life or death and his worst fears, until Mordo and Ancestral arrive. They discover that Ancestral immortality comes from the power of the Dark Dimension.

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When he is about to die his reward is the levitation cloak which is a magical relic capable of moving and flying under its own power, allowing its user to levitate and float in the air.

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Kaecilius wounds Ancestral and escapes to Hong Kong. Ancestral is taken to the Metro-General Hospital, and before she dies, her astral form tells Strange that he will also have to break the rules, as she did, for the good of the world and to balance nature.

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Strange and Mordo travel to the Hong Kong Sanctuary and find Wong dead with several wizards and the Sanctuary destroyed, while the Dark Dimension is destroying Earth. Strange uses the Eye of Agamotto to go back in time to save Wong, then creates an endless time loop within the Dark Dimension in which he locks himself and Dormammu forever. After killing Strange indefinitely without success, Dormammu reluctantly agrees to leave Earth if Strange undoes the loop, taking Kaecilius and his Fanatics with him.

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Strange saves the Eye, which Wong reveals to be actually an Infinity Stone, in Kamar-Taj, and then moves to the Sanctuary in New York to continue his studies. Strange is visited by Thor, who has brought his brother Loki to Earth to search for his father Odin. He decides to help them, in exchange for them leaving Earth once they meet his father again.