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Traces of smallpox was found on the head of the mummy of the Pharaoh Ramses V.

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In China, a written description of a disease that clearly resembles small pox is found where people will appealed to the god Yo Hoa Long for protection from smallpox.

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Trading between China and Korea  bring smallpox to Japan. A myth that was believed all around the world was that red light would cure smallpox

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Smallpox is widespread in India. Arab expansions spreads smallpox into northern Africa, Spain, and Portugal.

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Smallpox spreads to Asia Minor, the area of present-day Turkey.

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Crusades further contribute to the spread of Europe.

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Smallpox moves north.

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Increased use of variolation in the Ottoman Empire and North Africa.

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Smallpox spreads into North America.

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Lady Mary Wortley Montagu, a survivor if smallpox, had both her children variolated.

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Edward Jenner shows how cowpox can be used to create a vaccine for smallpox.

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Smallpox was widespread in Africa, Asia, and South America in the early 1900s although, Europe and North America have it under control through the help of mass vaccination.