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An amine is generally a functional group with a nitrogen atom having a lone pair. Amines resemble ammonia structurally where nitrogen can bond up to 3 hydrogen atoms. It is also characterized by various properties that are based on carbon connectivity.

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Primary amines react with nitrous acid to yield a diazonium salt, which is highly unstable and degradates into a carbocation that is capable of reaction with any nucleophile in solution. Therefore, reacting primary amines with nitrous acid leads to a mixture of alcohol, alkenes, and alkyl halides.

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The lower aliphatic amines are gaseous in nature. They have a fishy smell.

Primary amines with three or four carbon atoms are liquids at room temperature whereas higher ones are solids.

Aniline and other arylamines are generally colourless.

Lower aliphatic amines can form hydrogen bonds with water molecules.

Higher amines are insoluble in water. Organic solvents like alcohol, benzene and ether readily dissolve amines.

Alcohols have higher polarity as compared to amines and hence, they form stronger intermolecular hydrogen bonds.

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It is used in water purification, medicine manufacturing and development of insecticides and pesticides.

It is used in water purification, medicine manufacturing and development of insecticides and pesticides.

Serotonin is an important amine that functions as one of the primary neurotransmitters. It controls the feelings of hunger and is critical for the speed with which the brain operates in general.

Pain-relieving medicines such as Morphine and Demerol which are also known as analgesics are made from amines.

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Primary Amines: When one of the hydrogen atoms of the ammonia molecule is replaced by an alkyl or aryl group.

Secondary Amines: Two organic substituents replace the hydrogen atoms of the ammonia molecule forming an amine.

Tertiary Amines: When all 3 of the hydrogen atoms are replaced by an organic substituent, it could be an aryl or aromatic group.

Cyclic Amines: These are secondary or tertiary amines in an aromatic ring structure.

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Amines play an important role in the survival of life – they are involved in the creation of amino acids, the building blocks of proteins in living beings. Many vitamins are also built from amino acids.

Serotonin is an important amine that functions as one of the primary neurotransmitters for the brain. It controls the feelings of hunger and is critical for the speed with which the brain operates in general. It also affects the state of happiness and helps in regulating the sleeping and waking-up cycle of the brain.

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https://byjus.com/chemistry/amines/

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Introduction to Amines - Compounds Containing Nitrogen

Amines are one of the most important classes of organic compounds which can be derived when we replace one or more hydrogen atoms of ammonia molecule with an alkyl group.

Table of contents

What are Amines?

An amine is generally a functional group with a nitrogen atom having a lone pair. Amines resemble ammonia structurally where nitrogen can bond up to 3 hydrogen atoms. It is also characterized by various properties that are based on carbon connectivity.

Compounds of nitrogen connected to a carbonyl group are called as amides, they have a structure R-CO-NR′R″ and vary in properties with amines.

Amines are organic compounds that contain nitrogen atoms with a lone pair. Basically, they are derived from ammonia (NH ₃) in which one or more hydrogen atoms is replaced by an alkyl or aryl group, and so they are known as alkylamines and arylamines respectively.

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Amine Structure

Nitrogen has 5 valence electrons and so is trivalent with a lone pair. As per VSEPR theory, nitrogen present in amines is sp ³ hybridized and due to the presence of lone a pair, it is pyramidal instead of tetrahedral shape which is a general structure for most sp ³ hybridized molecules. Each of the three sp3 hybridized orbitals of nitrogen overlap with orbitals of hydrogen or carbon depending upon the configuration of amines. Due to the presence of a lone pair, the C-N-H angle in amines is less than 109 degrees which is a characteristic angle of tetrahedral geometry. The angle of amines is near about 107 degrees.

Occurrence of Amines

Naturally, amines occur in proteins, vitamins, hormones, etc. and they are also prepared synthetically to make polymers, drugs, and dyes.

Types of Amines
On the basis of how the hydrogen atoms are replaced by an ammonia molecule, amines can be divided into 4 types.

1. Primary Amines
When one of the hydrogen atoms of the ammonia molecule is replaced by an alkyl or aryl group.

2. Secondary Amines
Two organic substituents replace the hydrogen atoms of the ammonia molecule forming an amine.

Eg: Dimethylamine (CH ₃)2NH, Diphenylamine (C ₆H ₅) ₂ NH

3. Tertiary Amines
When all 3 of the hydrogen atoms are replaced by an organic substituent, it could be an aryl or aromatic group.

Eg: Trimethylamine N(CH ₃) ₃, Ethylenediaminetetraacetic acid (EDTA)

4. Cyclic Amines
These are secondary or tertiary amines in an aromatic ring structure. Eg: Piperidine (CH ₂) ₅NH, Aziridines C ₂H ₅ N

Preparation of Amines
Some processes for preparing primary amines are mentioned below.
Preparation of Primary Amines

1. Making of amines from halogenoalkanes

This process will be carried out in a sealed tube. Here haloalkanes will be heated with the concentrated solution of ammonia in ethanol. The mixture cannot be heated under the reflux as ammonia would move out in the form of gas from a container.

Now coming to the preparation of primary amine from halogenoalkane, the reaction takes place in two stages. Salt will be formed at the first stage. Here ethyl ammonium bromide is the salt. It is similar to ammonium bromide except for the fact that one of the hydrogens in the ammonium atom is replaced by an ethyl group.

A reverse reaction can occur between ammonia and the salt. It is illustrated in the above reaction.
2. Reduction of nitriles

We can get primary amines when nitriles are reduced with lithium aluminium hydride. This method is mainly used for the preparation of amines which contain one carbon atom more than the starting amine.

3. Gabriel phthalimide synthesis

We can get primary amines easily by Gabriel synthesis. In this process, on the treatment of phthalimide with ethanolic potassium hydroxide, we get potassium salts of phthalimide. When this is further heated with alkyl halide followed by alkaline hydrolysis then primary amine is produced. We cannot prepare aromatic primary amines because aryl halides do not undergo nucleophilic substitution with the anion which is formed by phthalimide.

Basicity of Amines

Similar to ammonia, primary & secondary amines have protic hydrogens and thus they showcase a degree of acidity. Whereas tertiary amines have no protic hydrogen and thus do not possess a degree of acidity.

pK a value for primary & secondary amines is about 38, which makes them a real weak acid. Whereas if we take the pK b, it is about 4. This makes the amines much more basic than acidic. Thus, an aqueous solution of an amine is strongly alkaline.

Uses of Amines
Amines have a widespread application in our daily lives. Some uses of amines are listed below:

It is used in water purification, medicine manufacturing and development of insecticides and pesticides.

It is involved in the production of amino acids which is the building block of proteins in living beings. Many varieties of vitamins are also made by amines.

Serotonin is an important amine that functions as one of the primary neurotransmitters. It controls the feelings of hunger and is critical for the speed with which the brain operates in general.

Pain-relieving medicines such as Morphine and Demerol which are also known as analgesics are made from amines.

What is the order of basicity of Amines?

Ans: Due to the presence of lone pair electrons on the nitrogen atom of amine, it has the ability to donate a pair of electrons to form a base. The basicity of amines depends upon following factors, stectric factors, Electronic factor and solvent factor,
In the gaseous state, the order of basicity of amine, when R=Me, 3 ⁰ > 2 ⁰ > 1 ⁰.
In the aqueous solution the order of basicity of amine, when R= Me, 2 ⁰ > 1 0 > 3 ⁰
In the aqueous solution the order of basicity of amine, when R= Et, 2 ⁰ > 3 0 > 1 ⁰

What is the difference between amine and amide?

Amines and amides are two different types of organic compounds. The difference between amine and amide is the presence of a carbonyl group in their structure; amines have no carbonyl groups attached to the nitrogen atom; the formula of amine is RNH ₂ whereas amides have a carbonyl group attached to a nitrogen atom; the formula of amide is R-CO- NH ₂.

What are the uses of amines ?

Amines are used as water purification, medicine manufacturing and development of insecticides and pesticides. It is also involved in the production of amino acids which is the building block of proteins .

Are amines harmful?

Generally most of the aliphatic amine found in the food, are involved in the production of amino acids,which is the building block of proteins. So these are not highly toxic in nature, However some aromatic amines cause irritans on the skin and may be toxic in nature.

How many types of amine are there?

Depending upon the number of alkyl or aryl groups attached to the nitrogen atom, the aliphatic or aromatic amines are classified as primary , secondary and tertiary amines.

From the above discussion, students would have gained some understanding of the basic concepts of amines but to know more about amines, chemical and physical properties of amines, register with BYJU'S.

Frequently Asked Questions - FAQS

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Amines - Formula, Structure, Nomenclature, Classification, Preparation, Basicity, FAQs and Videos of Amines.

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An amine is generally a functional group with a nitrogen atom having a lone pair. Amines resemble ammonia structurally where nitrogen can bond up to 3 hydrogen atoms. It is also characterized by various properties that are based on carbon connectivity.

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https://www.toppr.com/guides/chemistry/amines/physical-properties-of-amines/