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PRINCE-SSP is NIHR funded pragmatic non-inferiority randomised trial investigating needle aspiration versus chest drain in people with secondary spontaneous pneumothorax (SSP).

More Information: PRINCE-SSP

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CRASH-4 November 2023 Recruitment Update

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PRINCE-SSP Summary Participant Information Sheet V1.0 14Feb23

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Leeds General Infirmary

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Leeds General Infirmary

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Leeds General Infirmary

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Dr Taj Hassan

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St James's University Hospital

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Tadas Mazeika

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Spot Available

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With 1260 recruited we can finally look at the (blinded) trial data to see if we are recruiting the right group of patients.

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CRAFFT (IRAS 264593)
Children’s Radius - Acute Fracture Fixation Trial: A multi-centre prospective randomised non-inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children.

Crescent (IRAS 1004295)

Investigating the effects of carbogen (95% oxygen, 5% carbon dioxide) for management of seizures in children.

Website:

CRESCENT (crescent-trial.org.uk)

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The Associate Principal Investigator Scheme aims to develop health and care professionals to become the Principal Investigators (PIs) of the future.

What is it?
A 6 month in-work training opportunity to gain practical experience within healthcare research

Why?
Personal development
Formal recognition of engagement in NIHR Portfolio research

Who?
Any healthcare professional who would like to get involved in research

How?
Contact our study team to find out more about current studies we are running with the associate PI scheme in place!

More information about the scheme can be found here.

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Spot Available

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Dr Awais Saeed

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Spot Avalable

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A&E Admin Offices

Leeds General Infirmary

Great George Street, Leeds

LS1 3EX

Infection and Emergency Medicine Research Office

Gledhow Wing, Level 8

St James's University Hospital, Leeds LS9 7TF

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RESCUE (Rapid Evaluation with Scrotal Ultrasound prior to Exploration): additional information here.

DAShED2 (Comparing strategies for investigating Acute Aortic Syndrome (AAS) in the Emergency Department (ED): additional information TBC.

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Good Clinical Practice (GCP) is the international ethical, scientific and practical standard to which all clinical research is conducted. Compliance with GCP assures patients and the public that the rights, safety and well-being of people taking part in studies are protected and that research data is reliable.

Free GCP training course for people supporting clinical research delivery at the NHS, UK universities and other publicly funded organisations in England is available here.

First time learner:
- GCP eLearning (March 2024) course.

Refresher (every 2 years):
- GCP Refresher eLearning (March 2024) course.

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TiLLI (PI: Dr Andy Webster)

Thromboprophylaxis in Lower Limb Immobilisation: a study comprising two linked randomised controlled trials evaluating the effectiveness and cost effectiveness of different methods of pharmacological prophylaxis for patients with temporary lower limb immobilisation.

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We would be really grateful for interest from any of the ED consultants in becoming a Principal Investigator (PI) on either of our potential studies.

If you have never been a PI, please do not let that deter you! We will provide full support and it is a really interesting addition to ones overall portfolio.

For more information please contact us.

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CRASH-4 trial is a randomised, double-blind, placebo-controlled trial to test the safety and efficacy of tranexamic acid (TXA) for symptomatic mild head injury in 10,000 older adults. The patients, researchers and the clinical team caring for the patients will not know which study group the patients are in. The trial will be conducted by ambulance services and hospital emergency departments in the UK.

Website: CRASH-4 Study

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ASPIRED is a UK open prospective parallel group multi-centre randomised controlled trial. RCT of an immediate 14-day ambulatory patch heart monitor versus standard care monitoring (Holter/extended ambulatory monitor as per NICE guidance) in 2234 participants presenting acutely with unexplained syncope. The patient focussed primary endpoint will be number of episodes of syncope at one year.

Website: ASPIRED Study

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Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients: The ASPIRED study.

Chief Investigator: Dr Matt Reed

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Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients: The ASPIRED study. Chief Investigator: Dr Matt Reed

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Honorine Jobain

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Kiran Chana

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Tadas Mazeika

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Dr Clare Thompson

Dr Catherine Holmes

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Dr Najeeb Rahman

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Dr Taj Hassan

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CoMiTED is an NIHR-HTA funded randomised controlled trial to find out whether a collapsed lung (pneumothorax) due to injury (trauma) can be safely and effectively treated without immediately inserting a tube into the chest (chest drain). 750 adult patients with a collapsed lung after trauma will be recruited from (at least) 25 hospital Emergency Departments in the UK.

Website: CoMiTED

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ED Consultant & the Chair of Leeds-EMeRG group:

Dr Taj Hassan

taj.hassan@nhs.net

ED Consultant:

Dr Najeeb Rahman

najeebrahman@nhs.net

Paediatric ED Consultant:

Dr Alice Downes

alice.downes@nhs.net

Senior Research Nurse:

Claire Reidy

claire.reidy@nhs.net

Research Nurse:

Honorine Jobain

honorine.jobain@nhs.net

Clinical Research Practitioner:

Kiran Chana

kiran.chana@nhs.net

Clinical Research Practitioner:

Tadas Mazeika

tadas.mazeika@nhs.net

Research Practitioner:

Claire Forrest

claireforrest@nhs.net

For any general enquiries:

leedsth-tr.lemerg@nhs.net
ext. 25729 (mob: 01133925729)
Mon - Fri, 08:00 AM - 16:00 PM