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                                                                                                                      CARDIOMYOPATHY & GENETICS

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                                                                                                                      CARDIOMYOPATHY & GENETICS

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Description: Cardiomyopathy is a diagnosis that is associated with muscle or electrical dysfunction of the heart (Wexler et al. 2009). Cardiomyopathy can be caused by genetic factors or environmental factors, but is most commonly due to a combination of both genetics and environment. 

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Description: Cardiomyopathy is a diagnosis that is associated with muscle or electrical dysfunction of the heart (Wexler et al. 2009). Cardiomyopathy can be caused by genetic factors or environmental factors, but is most commonly due to a combination of both genetics and environment. 

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Symptoms of cardiomyopathy may include: shortness of breath, chest pain, rapid or irregular heartbeats, swelling of ankles, feet, stomach and neck, bloating, coughing, difficulty laying flat, dizziness, fatigue, fainting and sudden cardiac death (Precone et al. 2019).

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Symptoms of cardiomyopathy may include: shortness of breath, chest pain, rapid or irregular heartbeats, swelling of ankles, feet, stomach and neck, bloating, coughing, difficulty laying flat, dizziness, fatigue, fainting and sudden cardiac death (Precone et al. 2019).

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Life expectancy for someone with cardiomyopathy can vary greatly depending on the severity of the disease. With proper care and treatment, most individuals can live long and full lives (Ciarambino et al. 2021). Cardiomyopathy can run in families and scientists have identified genes such as MYBPC3, MYH7,TNNT2, TNNI3, TPM1, ACTC, MYL2,MYL3, and LMNA that can be passed down through generations and increase your risk for cardiomyopathy.

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Life expectancy for someone with cardiomyopathy can vary greatly depending on the severity of the disease. With proper care and treatment, most individuals can live long and full lives (Ciarambino et al. 2021). Cardiomyopathy can run in families and scientists have identified genes such as MYBPC3, MYH7,TNNT2, TNNI3, TPM1, ACTC, MYL2,MYL3, and LMNA that can be passed down through generations and increase your risk for cardiomyopathy.

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 It is important to understand this disease, because cardiovascular disease is the leading cause of death in the United States with most cases having some genetic component. While you are unable to change any genetic predisposition to the disease, knowledge of the environmental contributions to this disease can help manage or even prevent it from occurring (Precone et al. 2019).

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 It is important to understand this disease, because cardiovascular disease is the leading cause of death in the United States with most cases having some genetic component. While you are unable to change any genetic predisposition to the disease, knowledge of the environmental contributions to this disease can help manage or even prevent it from occurring (Precone et al. 2019).

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Prevalence of cardiomyopathy: : Hypertrophic cardiomyopathy: 1/500 adults. Dilated cardiomyopathy: 1/250 adults. Right ventricular cardiomyopathy: 1/5,000 adults (Kim & Pereira, 2021)

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Prevalence of cardiomyopathy: : Hypertrophic cardiomyopathy: 1/500 adults. Dilated cardiomyopathy: 1/250 adults. Right ventricular cardiomyopathy: 1/5,000 adults (Kim & Pereira, 2021)

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Risk Factors for Cardiomyopathy include: smoking, hypertension, diabetes, obesity, dyslipidemia and family history (Adhikary et al. 2022)

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Risk Factors for Cardiomyopathy include: smoking, hypertension, diabetes, obesity, dyslipidemia and family history (Adhikary et al. 2022)

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Testing for cardiomyopathy can include: Electrocardiogram, blood test (BNP), stress test, echocardiogram, heart catheterization, cardiac angiogram and heart biopsy (Adhikary et al. 2022).

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Testing for cardiomyopathy can include: Electrocardiogram, blood test (BNP), stress test, echocardiogram, heart catheterization, cardiac angiogram and heart biopsy (Adhikary et al. 2022).

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Treatment may include: smoking cessation, exercise, salt intake monitoring, weight loss, medications such as Beta Blockers and Calcium Channel Blockers, a surgically implanted device such as pacemaker and/or defibrillator, ablation procedures for electrical issues and heart transplant for severe cardiomyopathy (Precone, 2019).

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Treatment may include: smoking cessation, exercise, salt intake monitoring, weight loss, medications such as Beta Blockers and Calcium Channel Blockers, a surgically implanted device such as pacemaker and/or defibrillator, ablation procedures for electrical issues and heart transplant for severe cardiomyopathy (Precone, 2019).

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-	A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of dangerous irregular heartbeats (Yamada & Nomura, 2021). 

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-	A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of dangerous irregular heartbeats (Yamada & Nomura, 2021). 

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While cardiomyopathy can cause disability and death, early diagnosis and treatment/intervention can greatly improve the quality of life and decrease the progression of the disease (Yamada & Nomura, 2021).

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While cardiomyopathy can cause disability and death, early diagnosis and treatment/intervention can greatly improve the quality of life and decrease the progression of the disease (Yamada & Nomura, 2021).