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As Christianity was established it caused Rome to lose its culture. The belief in one God made the Emperor seem unholy and there was overall less respect for leaders.

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Rome depended heavily on slaves. As they were expanding it was easy to enslave more people, but as they stopped expanding the supply was too low.

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Everything was so hectic and Rome over expanded so much that it caused it to be difficult for anyone to maintain power. There was constant conquering and rebellion.

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At this time, prices for goods in Rome were constantly increasing. This dwindled the ability for middle and lower class people to survive.

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Although the thought of "bigger is better" may cross your mind, Rome's expansion definitely got out of hand. They ended up facing many more attacks because of this which lead to lack of communication with their military.

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There were various barbarian tribes that attacked Rome. The migration of the Huns lead other dangerous foreigners into Rome's territory.

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Education on using sanitary tools and piping were limited, thus resulting in a high rate of sickness, disease, and death. There also were not many doctors or effective treatment or diagnosis plans in place at this time.

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The need to replace citizen soldiers with mercenaries had a huge effect on patriotism and dwindled the trust that needed to be put into the military. The upper class chose to focus on themselves through luxury rather than helping benefit Rome. Providing "breads and circuses" was considered one of the biggest downfalls as it was so costly.

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As the military got bigger and more established and the government became more needy, taxes were raised. Farm land became less productive causing farmers to leave their land and sink into poverty along with the members of the middle class. Lastly, there was an overall population decline which never leads to a good outcome.

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As the government became more controlling and oppressive, it drove away the support of the people. Similar to this was how the people lost trust in officials as they became corrupt. Lastly, the Eastern Roman empire was much richer than the west but they did little to help the west in time of civil war. This divided Rome beyond repair.