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For the experiment in Tube 1 they add 35S labeled bacteriophage and E. coli bacteria. In Tube 2 they add 32P labeled bacteriophage and E. coli bacteria. They blend it up to remove the bacteriophage coats and separate the coat from the cells using a centrifuge. The radioactive phosphorus (32P) appeared inside the cells. None of the radioactive sulfur (35S) appeared in the cells.

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Alfred Hershey & Martha Chase designed an experiment to answer the question, “What is the hereditary material

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Conclusion:

Contribution to DNA model:

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Conclusion:

Contribution to DNA model:

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Chargaff separated the purine bases and the pyrimidine bases using paper chromatography. He then determined how much of each base there was for several different organisms.

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Chargaff noticed that DNA contained equal amounts of adenine and thymine and equal amounts of cytosine and guanine.

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Conclusion:

Contribution to DNA model:

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James Watson and Francis Crick wanted to determine the 3-dimensional structure of DNA. He generated DNA crystals and shot x-rays to study his structure, the x-ray picture showed a repeated pattern which meant to be something similar to a helix.

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Conclusion: 

Contribution to DNA model: 