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Take a Lyme Disease Antibiotic: Doxycycline (a bactericidal drug - prevents cell wall synthesis), Amoxicillin (a bactericidal drug - prevents cell wall synthesis), or Cefuroxime Axetil (a bacteriostatic drug - prevents protein synthesis)

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Take a Lyme Disease Antibiotic: Doxycycline (a bactericidal drug - prevents cell wall synthesis), Amoxicillin (a bactericidal drug - prevents cell wall synthesis), or Cefuroxime Axetil (a bacteriostatic drug - prevents protein synthesis)

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green = a way the bacteria escapes the immune system

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green = a way the bacteria escapes the immune system

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A potential drug that breaks down the biofilm

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A potential drug that breaks down the biofilm

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The bacteria relies on manganese to fuel itself and preform tasks instead of iron, the primary source of nutrients for many other bacteria

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The bacteria relies on manganese to fuel itself and preform tasks instead of iron, the primary source of nutrients for many other bacteria

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Go to a doctor for different treatment options (ex: antibiotic)

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Go to a doctor for different treatment options (ex: antibiotic)

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-Use tick repellent               -See doctor immediately if bitten by a tick                  -Wear long clothing and avoid forest and bushes

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-Use tick repellent               -See doctor immediately if bitten by a tick                  -Wear long clothing and avoid forest and bushes

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Even with treatment, symptoms can still be present because the bacteria could be surviving in hard to access areas, like the joints

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Even with treatment, symptoms can still be present because the bacteria could be surviving in hard to access areas, like the joints

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This causes many of the symptoms of the disease

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This causes many of the symptoms of the disease

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Because of their shape, the bacteria can push their way into cells (specifically cells in the nervous and cardiovascular systems and the joints)

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Because of their shape, the bacteria can push their way into cells (specifically cells in the nervous and cardiovascular systems and the joints)

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The bacteria can form a biofilm, which is a protein barrier that protects the bacteria from the immune cells or antibiotics 

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The bacteria can form a biofilm, which is a protein barrier that protects the bacteria from the immune cells or antibiotics 

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The bacteria can also change which proteins are on the outermost layer of the cell, causing it to be seen as familiar (a fit) to cell receptors

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The bacteria can also change which proteins are on the outermost layer of the cell, causing it to be seen as familiar (a fit) to cell receptors

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Once the body realizes that the bacteria is a threat, it tries to attack it, but can't. Instead, the body has an inflammatory response which damages tissues.

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Once the body realizes that the bacteria is a threat, it tries to attack it, but can't. Instead, the body has an inflammatory response which damages tissues.

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A certain protein (Salp15) in the tick's saliva repress the immediate immune response an inhibits the mobilization and activation on antigen-presenting cells. Also, downregulation of cathelidicin + defensin furthermore helps to allow the bacteria to enter the body undetected to the immune cells for up to a few weeks 

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A certain protein (Salp15) in the tick's saliva repress the immediate immune response an inhibits the mobilization and activation on antigen-presenting cells. Also, downregulation of cathelidicin + defensin furthermore helps to allow the bacteria to enter the body undetected to the immune cells for up to a few weeks 

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B. burgdorferi is extremely effective at disguising itself from the immune system

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B. burgdorferi is extremely effective at disguising itself from the immune system

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Once in the host, the spiral-shaped bacteria travels through the bloodstream to infect many different parts of the body

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Once in the host, the spiral-shaped bacteria travels through the bloodstream to infect many different parts of the body

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B. burgdorferi is injected into the host during the bite (usually 36-48 hours)

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B. burgdorferi is injected into the host during the bite (usually 36-48 hours)

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The bacteria then travels to the salivary glands of the tick

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The bacteria then travels to the salivary glands of the tick

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The bacteria in the midgut of the tick begins to multiply after ingesting the nutrients from the bloodmeal (relying on manganese)

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The bacteria in the midgut of the tick begins to multiply after ingesting the nutrients from the bloodmeal (relying on manganese)

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The bacteria reaches the midgut of the tick and stays there

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The bacteria reaches the midgut of the tick and stays there

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A tick larvae (Ixodes scapularis: blacklegged tick) feeds on a rodent infected with the borrelia burgdorferi bacteria

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A tick larvae (Ixodes scapularis: blacklegged tick) feeds on a rodent infected with the borrelia burgdorferi bacteria