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E.coli is caused by the bacterium  Escherichia coli. Even though that this bacterium lives in the digestive track of warm blooded animals, outside of the digestive track is where disease is caused.

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E.coli is transmitted to humans primarily through the consumption of raw or undercooked ground meat products, raw milk, and contaminated raw vegetables. Also, contaminated water that is ingested can present E.coli.
If left untreated E.coli toxins (Shiga toxins)destroy red blood cells in a process called hemolysis. This can lead to kidney failure and death.

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https://www.cdc.gov/ecoli/general/index.html#:~:text=Most%20E.,outside%20of%20the%20intestinal%20tract.

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Symptoms of E.coli include diarrhea(often bloody), stomach pain, cramps and low grade fever.

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To prevent E.coli throughly wash hands, counters, cutting boards, and utensils after being exposed to raw meat and vegetables. Avoid swallowing water while swimming in pools, lakes, ponds, and streams.

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Unfortunately there are no current treatments that can cure E coli. For most the best thing that can be done is to get plenty of rest and fluids. Fluids will help prevent dehydration and fatigue.

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Humans of all ages are likely to get E.coli, but those that are more susceptible are: adults 65 and older, children younger than the age of 5, people with weakened immune systems, and people who travel to certain counties.