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The first effect of running disk-cleanup will be purely conditional on the fact that your lack of storage was causing your performance drops. Therefore if this is the case, clearing un-necessary files can definitely improve your runtime performance by either ensuring that there is enough temporary storage for your programs to use which isn't stored in the RAM, or it will ensure that if your RAM does happen to fill up, there is enough swap memory available to prevent your system from crashing, which is always a good thing.

Another effect is that you may have noticably more personal storage available. If your drive was filling up, you may not have enough room in the future to save pictures, music or any other personal documents, which you will now be able to avoid by having that additional storage space.

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Generally, it's always best practice to run any sort of maintenance utility software somewhat frequently, to ensure that your system is remaining safe and swift.

However, if you notice that your system is starting to feel a little slow and can see that the storage has filled up considerably, it'd always be a good place to start to run disk clean-up so that you can clear up any un-used space in your drive.

If you have recently updated your Windows version and are certain that you won't need to rollback, running Disk Clean-up can also delete your previous windows installation backups for you, allowing you to save 20GB+ of storage space.

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tldr; it frees up some storage, which could improve general performance.

It's very often that as time goes on, your computer can start to feel sluggish and slow as you accumulate more and more data in your hard-drive.

As more sectors of your drive are filled up, there is less storage for newer applications and processes to use. This can also be especially apparent if you're running low on memory, where parts of your storage will also be used as swap.

So, how does Disk Cleanup help?
Disk Clean-up helps by searching your drive files that are either no longer in use, temporary or generally just unnecessary. This can give you back an amount of storage which may or may not be significant depending on how long it has been since the last scan.

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Disk Clean-up is a piece maintenance utility software developed for Windows, which is used to clear up un-necessary files on a specific drive such as temporary files, cached webpages and recycle-bin items.

Disk Clean-up does NOT remove personal files such as photos, games or documents. It only removes information that has either been recycled or is no longer being used by the operating system. In the pop-up that appears, you can select everything that you would like to be cleared.