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The origin of depressants are said to be dated back in 1832. There is a drug called Chloral Hydrate which was used for sedation and sleeping induced drugs. It replaced opium, alcohol and many other depressants. It eventually became a popular street drug. However, the poisoning in the substance has killed many. Early use of depressants date back to the 1800's. The usage of barbiturates and other depressants began in the 20th century. Alcohol also dates many years back.

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https://docs.google.com/a/konawaenahigh.k12.hi.us/document/d/16zBFEDxObMzQwDq0qpdTSGvOh5PvC6pDzqKT8P6LPmg/edit?usp=sharing

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An individual who is abusing depressants may show the following signs:

sedated or drowsy

talk slowly and may slur their speech

unable to concentrate

coordination and memory are likely to be off

poor concentration

lower inhibitions

poor control of their actions and may take risks they would not normally take

They may also show other symptoms of Depressant abuse, including but not limited to:

dizziness

slow breathing and heart rate

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Short term effects:

Slow brain function

Slowed pulse and breathing

Lowered blood pressure

Poor concentration

Confusion

Fatigue

Dizziness

Slurred speech

Fever

Sluggishness

Visual disturbances

Dilated pupils

Disorientation, lack of coordination

Depression

Difficulty or inability to urinate

Addiction

Long term effects:
Long-term use of depressants can produce depression, chronic fatigue, breathing difficulties, sexual problems and sleep problems. As a dependency on the drug increases, cravings, anxiety or panic are common if the user is unable to get more.
Withdrawal symptoms include insomnia, weakness and nausea. For continual and high-dose users, agitation, high body temperature, delirium, hallucinations and convulsions can occur. Unlike withdrawal from most drugs, withdrawal from depressants can be life-threatening.
These drugs can also increase the risk of high blood sugar, diabetes, and weight gain

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Slogan:

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A depressant, or central depressant, is a drug that lowers neurotransmission levels, which is to depress or reduce arousal or stimulation, in various areas of the brain. Depressants are also occasionally referred to as "downers" as they lower the level of arousal when taken. Stimulants or "uppers" increase mental and/or physical function, hence the opposite drug class of depressants is stimulants, not antidepressants.

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Depressants : Opioids/Opiates , Marijuana , Barbituates , Alcohol , Benzodiazepines .

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Uses: http://kidshealth.org/en/teens/depressants.html
Effects: Short  term: http://www.drugfreeworld.org/drugfacts/prescription/depressants.html
Long term:
https://image.slidesharecdn.com/health9longshortterm-161016202409/95/long-term-and-short-term-effects-of-drug-use-abuse-and-misuse-grade-9-lesson-in-mapeh-health-7-638.jpg?cb=1476649679
Symptoms:
https://addictionlibrary.org/prescription/depressants-sedatives-uses-symptoms-signs-and-addiction-treatment.html