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Mr Systrom, chief executive, said they were departing to "explore our curiosity and creativity again".

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Instagram, purchased by Facebook in 2012 for $1bn (£760m) in cash and stock, has more than a billion users.

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There had been reports of tension between the pair and Facebook

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They started out Instagram in 2010 and later on was purchased by Facebook

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Mr Systrom said: "We're now ready for our next chapter."

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"I've learned a lot working with them for the past six years and have really enjoyed it," he said. "I'm looking forward to seeing what they build next."

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CEO Mark Zuckerberg said in a statement that Instagram reflected the founders' "combined creative talents".

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tension started to grow between Mr Systrom and Mr Zuckerberg as far back as 2014 when Facebook purchased WhatsApp.

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Mr Systrom had sought to maintain Instagram's independence

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Mr Systrom had sought to maintain Instagram's independence

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They did not like te shared features like "instagram stories"

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Analysis by Dave Lee, BBC North America technology reporter

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Analysis by Dave Lee, BBC North America technology reporter

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The firm was quite deliberately treated like a separate company owned by Facebook

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Were responsible for that culture - the entire feel of an app that was in many respects the anti-Facebook.

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One of the names being touted as the next boss of Instagram.
He's currently head of product, and has a CV that some of Instagram's loyal users might find ominous

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Its chief executive and co-founder Jan Koum said in April he would quit the popular messaging service he co-founded in 2009 and sold to Facebook in 2014.

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- It has been under intense pressure this year over the issues of safeguarding customer data and the misuse of its platforms by those wishing to spread fake news, including for political ends.

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Mr Systrom and Mr Krieger met while studying at Stanford University.

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Instagram had about 30 million users in 2012

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It was also ad-free. That changed. But so did the number of users - now more than a billion.

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The Forbes billionaires list estimates Kevin Systrom's net worth at $1.4bn. 

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The Forbes billionaires list estimates Kevin Systrom's net worth at $1.4bn. 

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Mike Krieger's net worth is less. There are no definitive figures, ranging from $100m to $500m.