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Você sabia que existem muitos tipos celulares diferentes no músculo esquelético?

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Você sabia que existem muitos tipos celulares diferentes no músculo esquelético?

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O que significa o termo miocina para você?

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O que significa o termo miocina para você?

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Enquete: Músculo esquelético órgão ou tecido?

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Enquete: Músculo esquelético órgão ou tecido?

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Frontera e Ochala. 2014. Muscle Structure and Function.

Dumont et al., 2015. Intrinsic and Extrinsic Mechanisms Regulating Satellite Cell Function.

Bentzinger, Wang e Rudnicki, 2012. Building Muscle: Molecular Regulation of Myogenesis.

Giordani et al, 2019. High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations
Mitchell et al., 2010. Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development.

Dahal et al., 2014. Three dimensional reconstruction of the human skeletal muscle mitochondrial network as a tool to assess mitochondrial content and structural organization.

Wilke et al., 2018. Not merely a protective packing organ? A review of fascia and its force transmission capacity.

Purslow, 2010. Muscle fascia and force transmission.

Stefano Schiaffino e Carlo Reggiani. 2011. Fiber types in mammalian skeletal muscles.

Cruz et al. 2020. The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis

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Declaro  minha presença, Cinthia Maria Scholer.

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Declaro  minha presença, Cinthia Maria Scholer.

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Pederson e Febrario, 2012. Muscles, exercise and obesity: skeletal muscle as a secretory organ.

Görgens et al. 2015. Exercise and Regulation of Adipokine and Myokine Production.

Aryana et al., 2018. Myokine Regulation as Marker of Sarcopenia in Elderly.

Son et al., 2018. Exercise-induced myokines: a brief review of

controversial issues of this decade.

Piccirillo, 2019. Exercise-Induced Myokines With Therapeutic Potential for

Muscle Wasting.

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Parece ter efeitos mais cardioprotetores. Um artigo que me pareceu interessante é esse

10.1002/jcb.2915

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Affiliations

¹ Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.

² Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

³ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

⁴ Department of Nutrition, Faculty of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Affiliations

¹ Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.

² Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

³ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

⁴ Department of Nutrition, Faculty of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract

Heart failure (HF) is one of the prominent health concerns and its morbidity is comparable to many malignancies. Cardiac cachexia (CC), characterized by significant weight loss and muscle wasting, frequently occurs in progressive stage of HF. The pathophysiology of CC is multifactorial including nutritional and gastrointestinal alterations, immunological and neurohormonal activation, and anabolic/catabolic imbalance. Neurohormones are critically involved in the development of both HF and CC. Melatonin is known as an anti-inflammatory and antioxidant hormone. It seems that melatonin possibly regulates the neurohormonal signaling pathway related to muscle wasting in CC, but limited comprehensive data is available on the mechanistic aspects of its activity. In this, we reviewed the reports regarding the role of neurohormones in CC occurrence and possible activity of melatonin in modulation of HF and subsequently CC via neurohormonal regulation. In addition, we have discussed proposed mechanisms of action for melatonin considering its possible interactions with neurohormones. In conclusion, melatonin likely regulates the signaling pathways related to muscle wasting in CC by reducing tumor necrosis factor α levels and activating the gene expression of insulin-like growth factor-1. Also, this hormone inhibits the proteolytic pathway by inhibiting nuclear factor-κB (NF-κB), renin-angiotensin system and forkhead box protein O1 pathways and could increase protein synthesis by activating Akt and mammalian target of rapamycin. To elucidate the positive role of melatonin in CC and exact mechanisms related to muscle wasting more cellular and clinical trial studies are needed.

Keywords: cachexia; heart failure; melatonin; neurohormone.

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insulin-like growth factor i / metabolism

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proto-oncogene proteins c-akt / metabolism

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tor serine-threonine kinases / metabolism

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tumor necrosis factor-alpha / metabolism

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national center for biotechnology information

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The effects of melatonin on neurohormonal regulation in cardiac cachexia: A mechanistic review - PubMed

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Heart failure (HF) is one of the prominent health concerns and its morbidity is comparable to many malignancies. Cardiac cachexia (CC), characterized by significant weight loss and muscle wasting, frequently occurs in progressive stage of HF. The pathophysiology of CC is multifactorial including nut ...

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A busca com omega3 e miocina só encontrou 3 artigos. Então, ou é um tema que pode ser muito bom, já que há estudos bem interessantes de metabolismo, mas ainda foi pouco estudado. Ou não tem muita relação e resultados negativos são difíceis de publicar, por isso não achamos os artigos.

Segue o artigo que achei mais interessante da busca.

PMID: 28112528

PMID: 28112528

https://pubmed.ncbi.nlm.nih.gov/28112528/https://pubmed.ncbi.nlm.nih.gov/28112528/

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Randomized Controlled Trial

Affiliations

¹ Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

² Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Free article

Randomized Controlled Trial

Free article

Affiliations

¹ Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

² Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background: Omega-3 fatty acids have a protective role against cardiovascular disease and these protective properties are attributed to its anti-inflammatory effects. Myokines have anti-inflammatory properties and thereby reduce low-grade inflammation. Irisin, as a myokine, is considered to be therapeutic for human metabolic diseases. This study was conducted to determine the effects of Omega-3 fatty acids supplementation on serum irisin in men with coronary artery disease (CAD).

Methods: This study was an 8-week randomized, double-blind, placebo-controlled trial. Forty-eight CAD male patients (Omega-3, n = 24; control, n = 24) were randomly assigned to either Omega-3 or control groups by permuted block randomization method. Only the participants with more than 50% stenosis in at least one major coronary vessel were included. A total of 3 participants in the control group were excluded from the study. Forty-five participants (Omega-3, n = 24; control, n = 21) completed the study. Participants took Omega-3 fatty acids supplement (720 mg eicosapentaenoic acid plus 480 mg docosahexaenoic acid) or placebo (edible paraffin) for 8 weeks. Serum irisin, high-sensitivity C-reactive protein (hs-CRP), lipid profile and anthropometric indices, body composition, and food intake were assessed before and after intervention. Statistical analyses were performed using SPSS software. Paired t-test was used for evaluating within-group effects from baseline. Variables with normal distribution were compared by independent t-test between 2 groups.

Results: Compared to placebo, Omega-3 fatty acids increased serum irisin (P = 0.044) and decreased serum hs-CRP (P = 0.018) and LDL cholesterol (P = 0.031). Omega-3 fatty acids supplementation did not result in any significant changes in anthropometric measurements, blood pressure, serum lipids except for serum LDL, fasting blood glucose, body composition or serum insulin levels (all P > 0.05).

Conclusion: Omega-3 fatty acids supplementation could elevate serum irisin in male patients with CAD. Also, these fatty acids may able to decrease serum hs-CRP and LDL cholesterol.

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national center for biotechnology information

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Omega-3 Fatty Acid Could Increase One of Myokines in Male Patients with Coronary Artery Disease: A Randomized, Double-Blind, Placebo-Controlled Trial - PubMed

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Randomized Controlled Trial 1 Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. 2 Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.