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"In the Will work and acquire, and thou hast chained the wheel of Chance"

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Marie Curie was misunderstood by modern individuals as reckless in her study of radioactive atoms and isotopes. However, she followed a path of curiosity , that led her to discover many things about radiation that proved very useful to public safety and scientific advancement.

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Although his song has no lyrics it follows the protagonists journey through the stage, as well as her metaphorical journey. The song has three phases, in the first phase it is a relaxed melody then as she begins to race against her demons the melody begins to hasten and become more intense, until it finishes in a rushing piece. This demonstrates her journey and battle against herself, showing her self reliance to deal with her own internal issues.

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In the alchemist, Santiago, initially a nomadic shepherd, lives by his own work, in herding his flock. No sustenance "come[s] to him but through his toil bestowed".
On his journey he tempers his fate  "chain[ing] the wheel of Chance" to pursue a journey of self-discovery and self- reliance.