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장현준

CHEN SCARLET LAI

바트체렌 슈렝체첵

PRASANTI CALLISTA ELYSIA

엑셀

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Size: range from small to large + different shapes available

Color: skin tone --> ph detector (blue)

Material: wool, microporous material, silicone gel adhesive

Durability: can withstand water (microporous material)

Comfort: Flexible and moves with skin (silicone gel adhesive)

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1. Sensing Infection Markers: When a wound becomes infected, it releases specific chemical signals like changes in pH. An infected wound often has a more acidic or basic environment compared to a healing wound.

2. Embedded Reactive Dyes or Nanosensors: The bandage could contain special dyes or nanoparticles designed to respond to these infection markers. For example:

pH-sensitive dyes: These dyes change color when the pH levels shift. If a wound becomes more acidic (indicating infection), the bandage could shift from a neutral color to red.

3. Color Change Mechanism: Once these sensors detect the presence of infection indicators, they interact with the dyes, causing the bandage to change color. The color change alerts the user to a potential infection without needing additional tests.

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Nurses: no skin sensitivity, durability in terms of high activity

Pediatrician: child comfort, pain of removal from adhesion

Athletes: water/sweat resistance, high durability, skin breathability

Average Person: bandage that will provide sterilization and comfort in the healing process

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1. Outer Layer: Microscopic Silicone Layer

Purpose: This layer serves as a protective, waterproof barrier for the bandage, shielding the wound from external contaminants while allowing some breathability.

Material: Microporous silicone would be ideal, as it allows airflow while preventing bacteria and moisture from passing through. Tiny silicone pores would ensure breathability without compromising protection.

Application: This layer can be manufactured using a micro-perforation process or by creating a thin silicone sheet with micro-punctures. This technology could be applied by laminating a thin silicone film onto the top of the bandage.

2. Adhesive Layer: Silicone Adhesive

Purpose: Provides a skin-friendly, hypoallergenic adhesive to hold the bandage in place without causing irritation.

Material: Medical-grade silicone adhesive is commonly used for sensitive skin, as it sticks well but can be removed without causing skin damage.

Application: This adhesive would be applied in a thin layer under the silicone layer. It should ideally be designed to secure the bandage without interfering with any color changes in the inner layers.

3. Color-Changing Layer: Bromothymol Blue

pH Range: Changes color from yellow to blue between pH 6.0 and pH 7.6, which is closer to the pH range that could indicate infection in wounds.

Advantages: Bromothymol blue is more suitable for detecting subtle changes in pH that occur in the skin’s slightly acidic to neutral range.

Application: It can be embedded in a hydrogel or polymer layer within the bandage.4. Absorbent Layer: Wool Layer

Purpose: This layer would function as the absorbent “cotton” component, drawing in moisture and wound exudate. Wool is absorbent and can wick away fluids, helping to keep the wound dry and comfortable.

Material: Medical-grade, sterilized wool would be suitable for this purpose. Wool also has natural antibacterial properties, which could further support infection management.

Application: The wool layer should be positioned closest to the wound to absorb fluids, ensuring the phenolphthalein layer receives enough moisture to react if an infection is present.

Assembly Process

Each layer would need to be assembled in the following order:

1. Bottom (Wound-Facing) Layer: Wool absorbent layer.

2. Intermediate Layer: Phenolphthalein-embedded polymer layer for pH detection.

3. Adhesive Layer: Thin silicone adhesive applied to the outer edge of the phenolphthalein layer to secure it.

4. Outer Layer: Microporous silicone sheet laminated as a final protective cover.

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Key Considerations for Bromothymol Blue in a Bandage

1. pH Sensitivity Range

Range: Bromothymol blue changes color from yellow in acidic conditions (below pH 6.0) to blue in basic conditions (above pH 7.6). This range includes near-neutral pH levels, which are more likely to occur in an infected wound environment.

Suitability: This makes bromothymol blue an effective indicator for wounds, as infected wounds often show a shift toward neutral or slightly basic pH due to bacterial activity. The color change from yellow to blue could serve as a clear, visual cue for early infection detection.

2. Encapsulation and Safety

Encapsulation: To ensure skin safety, bromothymol blue should be embedded in a hydrogel or polymer matrix. This matrix acts as a barrier, preventing the dye from direct contact with the wound but allowing it to respond to changes in pH in the wound exudate.

Biocompatibility: Bromothymol blue is generally considered safe in controlled applications, but encapsulating it within a stable and medical-grade material is essential to avoid potential irritation. Medical-grade polymers or hydrogels, such as alginate, could be ideal for encapsulation, keeping the dye stable and isolated from the skin.

3. Breathability and Absorbency

Breathable Layers: To maintain an optimal healing environment, the outer layers of the bandage should be breathable, allowing airflow to the wound while keeping out contaminants. The breathable silicone layer and adhesive can help achieve this, making the bandage comfortable to wear.

Absorbency of Wool Layer: The wool or cotton absorbent layer should be designed to wick away moisture from the wound without oversaturating the bromothymol blue layer. This balance is crucial because bromothymol blue requires just enough moisture to sense the wound environment but may not function accurately if oversaturated.

Hydrogel Moisture Control: Using a hydrogel with controlled absorbency can help regulate moisture, ensuring the dye has enough contact with wound exudate to respond to pH changes effectively while preventing excess fluid buildup.

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leader : PRASANTI CALLISTA ELYSIA

expert users : 엑셀, 장현준

production : CHEN SCARLET LAI

marketing : 바트체렌 슈렝체첵

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Temperature Change Response: When body temperature changes, certain substances react sensitively to temperature and change color. For example, when the body temperature of a patient with fever rises above a certain level, the color changes and informs of a high fever.

pH Sensitive Reaction: Chemicals that change color according to changes in the pH of body fluids, such as blood and sweat, are sometimes used. The chemical structure and color change when the pH changes.

Humidity response: Substances that react to humidity are put inside the band, for example, discolored when detecting the risk of infection in the wound area, warning the user.

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pH indicators like bromothymol blue, methyl red, or phenolphthalein can be used since they change color at specific pH ranges.

bromothymol blue is the one that changes color between pH 6 and 8. Transitions from yellow at pH 6.0 to blue at pH 7.6.

The dyes are usually embedded in a hydrogel or fiber matrix, which acts as the foundation of the bandage.

The matrix can be created from biocompatible materials like cellulose, alginate, or silicone, which are safe for the skin and flexible enough to adapt to wound contours.

Microencapsulation may be used to stabilize the dyes and prevent them from leaching out while ensuring they remain sensitive to pH changes.

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