# data[].attributes.attachment_caption
Explanation: The correct answer is (C) Hip. The hip joint is one of the most commonly affected sites in osteoarthritis, along with the knee and the distal interphalangeal joints.

# data[].attributes.wish_content.attachment_props.question
Which of the following joints is most commonly affected by osteoarthritis?

# data[].attributes.body
Clinical diagnosis is based on the patient's history and physical exam:

Persistent activity-related joint pain in one or more joints

Age greater than 45 years

Morning stiffness less than 30 minutes in duration

Examination of the suspected joint may demonstrate mild tenderness to palpation, usually without evidence of inflammation. Crepitus, bony enlargement, decreased range of motion, joint effusion, and osteophytes along the periphery of the joint may be detectable.

Synovial fluid analysis, serum inflammatory markers, and joint radiographs can be used to assist in diagnosis

Typical features seen on radiographs include joint space narrowing, subchondral sclerosis, osteophytes at the periphery of joints, and subchondral cysts.

# data[].attributes.body
The Kellgren and Lawrence (KL) classification is a common method of classifying the severity of OA based on the presence of joint space narrowing and osteophytes

# data[].attributes.body
This case focused on an elderly male patient with multiple comorbidities as a candidate for an exercise program designed for improvement in hip osteoarthritis

In addition to weight loss, the patient showed marked improvement in the strength and use of the affected leg

With proper education and supervision, osteoarthritis can be improved in patients by the use of daily exercise, even if complex comorbidities are present

# data[].attributes.body
Wainwright, T. W., Immins, T., & Middleton, R. G. (2015). Hip osteoarthritis: patients with complex comorbidities can make exceptional improvements following intensive exercise and education. BMJ case reports, 2015, bcr2014208529. https://doi.org/10.1136/bcr-2014-208529

Inaba, M., & Ranganathan, P. (n.d.). Osteoarthritis. Washington Manual, 11(Rheumatology), 1–11.

# data[].attributes.attachment_link.title
The CHAIN (Cycling against Hip pAIN) Programme

# data[].attributes.body
The patient’s Oxford hip score and HOOS function values before and after treatment showed empiric improvement in the above figure.

The patient stated he felt markedly better after the six week program, and he continued to be physically active at home due to his success in regaining strength and range of motion in the affected hip.

Despite complex comorbidities, physicians should still evaluate an exercise plan for patients that is geared towards their abilities.

Exercise proves beneficial, not only in the relief of arthropathies, but also in the improvement of the patient’s other coexisting disorders.

# data[].attributes.body
71-years-old male previously diagnosed with hip osteoarthritis one year prior (confirmation with x-ray)

Additional medical problems included:

Ankylosing spondylitis affecting neck and lower spine for fifty years

Subtotal colectomy due to Crohn’s disease

Hypertension for over ten years

Type 2 Diabetes Mellitus

Gallstones

Mild Asthma and Bronchitis

Cartilage damage in the right knee with subsequent surgery on unspecified ligament in his twenties

Measurements were taken of the patient’s “Oxford hip score, the Hip disability and Osteoarthritis Outcome Score (HOOS)–function score weight, pain at rest and weight bearing (using a 0–10 visual analogue scale), sit-to-stand test (time taken to sit-to-stand five times), timed up and go test (time taken to rise from chair, walk 3 m, turn, return to sitting on chair), peak expiratory flow, and degree of flexion in the hip” prior to starting treatment

# data[].attributes.body
This patient underwent the “CHAIN” program: “Cycling against Hip PAIN”, consisting of a weekly one hour group session (thirty minutes of education/advice and thirty minutes of static cycling) for six weeks

An additional home-based cycling and exercise program was implemented

Education sessions discussed cycling technique, diet and pain relief

Due to the patient’s underlying conditions, the patient required additional time and education for optimal posturing on the bike and breathing control techniques

After evaluating this approach as a team, we agreed that physicians can undermine the importance of exercise with any treatment of diseases, especially chronic ones. Even those this patient was presented with the "complexity" of comorbidities, the patient's overall health improved with this exercise program, not only the goal of improving the patient's OA symptoms/difficulties.

# data[].attributes.body
National Institute for Health and Care Excellence (NICE) guidelines for all patients:

Education, advice and access to information

Exercise: muscle strengthening and aerobic fitness training

Weight loss if overweight or obese

After completing the basic guideline, some patients may benefit from drugs or injections, but very few need surgery.

# data[].attributes.body
This videos gives us a quick overview of Osteoarthritis, including the physiology, causes and risk factors, pathology, diagnosis and symptoms, and treatment.

Osteoarthritis is a degenerative joint disease usually caused by age-related breakdown of joint cartilage and underlying bone. This leads to stiffness and pain in weight-bearing joints that worsens with activity and improves with rest. Other symptoms of osteoarthritis include a grinding sensation when the joint is moved, and difficulty moving the affected joint. Risk factors for developing osteoarthritis include advancing age, obesity, and joint injury. Treatment involves losing weight, moderate exercise, physical therapy, and drugs to reduce pain and inflammation.

# data[].attributes.body
An increase in the aging population and higher obesity levels have experts predicting a two-fold increase in the incidence of hip-related arthropies in the next ten years within the UK.

# data[].attributes.body
For three decades, viola player Ruth Mann entertained audiences in Ireland and around the world as a member of the RTÉ Concert Orchestra, the BBC Northern Ireland Orchestra and the Ulster Orchestra. Being a professional musician was a career, but it was a lot more than that; playing music was her great love.

However, during the last 10 years of her playing life, Ruth experienced the devastating effects of osteoarthritis (OA) in her neck and hips. Her neck would seize up, she would ‘feel sick with the pain’, until finally she just couldn’t move her neck at all. The arthritis in her hips eventually got so bad that she had to use a wheelchair to get round. After numerous x-rays, tests and visits to doctors and surgeons, Ruth had to retire. ‘A career you really love – and a life – just gone. That wasn’t in the script,’ she says. She was 53.

After retiring, Ruth had both hips replaced and slowly started to build a new life. The Living Well with Arthritis self-management course was a game-changer. She took up new hobbies and had more time for old passions: yoga, painting, birdwatching, walking and gardening.

# data[].attributes.attachment_link.title
Living with Osteoarthritis - Ruth Mann's story

# data[].attributes.body
Philip Cohen, MD, associate clinical professor of internal medicine at UCLA, a primary care internist who also specializes in sports medicine, discusses the primary care management of osteoarthritis.

# data[].attributes.attachment_link.description
Listen to this episode from JAMA Clinical Reviews on Spotify. Philip Cohen, MD, associate clinical professor of internal medicine at UCLA, a primary care internist who also specializes in sports medicine, discusses the primary care management of osteoarthritis.

# data[].attributes.attachment_link.readable_text
Continuing Education Activity

Primary osteoarthritis is the most common form of arthritis that affects adults and the elderly. All providers, but especially primary care physicians, orthopedic surgeons, and rheumatologists are often involved in the diagnosis management of these patients. This article describes the pathophysiology, clinical diagnostic features, and management of primary osteoarthritis which emphasizes the need for collaboration among an interprofessional team.

Objectives:

Describe the pathophysiology of primary osteoarthritis.

Outline the typical clinical presentation of patients with primary osteoarthritis.

Review the principles in the management of primary osteoarthritis including non-medical, medical, and surgical options.

Discuss collaborative team strategies for improving care coordination and communication to enhance outcomes and advance the care of primary osteoarthritis.

Access free multiple choice questions on this topic.
Introduction

Osteoarthritis (OA) is the most common type of arthritis in clinical practice and is one of the leading causes of disability worldwide. The presence of radiographic evidence of OA occurs in most people by age 65 and is found in about 80% of those over age 75. OA can range from an asymptomatic condition to debilitating oligo or polyarthritis. Mechanical pain is the most common presenting symptom of this disease. The hands, knees, and hips are the most commonly affected joints, although any joint can be affected.[1]

Etiology

The etiology of primary osteoarthritis is poorly understood and involves both genetic and environmental factors. Epigenetics was found to contribute to the development of OA by 30% to 65%. Age is the strongest risk factor for OA and is believed to be linked to a decreased adaptability of the joint to resist biomechanical injury, sarcopenia, and increased bone turnover. Female gender is associated with a higher prevalence of OA due to gender differences in joint alignment, ligament strength, pregnancy, and bone density. Menopause, in particular, is associated with an increased risk of OA, suggesting a role of estrogen in OA development and pain sensitization. Anatomical factors, including joint malalignment or congenital deformities, can lead to biomechanical injury, increasing the susceptibility of developing OA. Modifiable environmental factors play a major role in the development of OA. This includes occupations requiring repetitive movements and obesity, metabolic syndrome, smoking, vitamin D deficiency, muscle weakness, and low bone density.[2][3][4][5]

Epidemiology

Osteoarthritis most commonly involves the hands, knees, feet, facet joints of the spine and hips, with the knee being the most common location. The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) estimated the global prevalence of knee osteoarthritis to be 263 million, with an incidence of 13 million per year. Women are at higher risk of developing primary OA than men and suffering from more severe disease. In particular, postmenopausal women are affected by the involvement of the hands, feet, and knees.[1][6]

Pathophysiology

The pathogenesis of osteoarthritis is multifactorial and interrelated. There are three major processes, including mechanical wear-and-tear, structural degeneration, and joint inflammation. The main process is believed to be due to the overuse of the joint and aging, although increased levels of several cytokines and chemokines in the affected joints' synovium suggest an inflammatory process is also present. Matrix metalloproteinases are activated and cause degradation of the cartilage extracellular matrix. The stress to cartilage promotes chondrocyte proliferation and activation, leading to the production of matrix-degrading enzymes. Later in the disease, chondrocytes undergo apoptosis, and the number of cells decreases overall.

On the anatomic level, OA's earliest process is articular cartilage damage, including surface fibrillation, irregularity, and focal erosions. Cartilage damage causes chondrocyte proliferation, and outgrowths can ossify and form osteophytes or bone spurs.

Subchondral bone sclerosis and bone cyst formation occur later in the disease and may increase joint stiffness and pain. Advanced disease results in episodic synovitis. Although rare, bony erosions may occur in erosive OA.[7][8]

Histopathology

In a healthy synovial joint, bone ends are linked by an elastic layer of articular hyaline cartilage. This layer mainly consists of water, type II collagen that maintains the structure, and proteoglycans that provide the cartilage with the ability to withstand compressive and shear forces.

Early in osteoarthritis, loss of proteoglycans disrupts the cartilage fibers, leads to the softening of cartilage, and increases the water content. The earliest sign of cartilage damage observed by light microscopy is chondral fibrillation, followed by cracks and deeper fissures. Cartilage loss promotes chondrocyte proliferation and activation. Fibroblasts in, a type I collagen matrix fills the areas that have lost cartilage and are called a "pannus." The remodeled matrix can then become calcified and invaded by small vessels later in the disease.

In end-stage disease, the subchondral bone becomes thicker and sclerotic. The margins of the articular bone form outgrowths called "bone spurs" or "osteophytes." Bone cysts may appear connected to the subchondral surface by a fissure filled with inflammatory fluid, myxoid material, or bone fragments.[8][7]

History and Physical

Classically, osteoarthritis presents with joint pain that is worse with use and improves with rest. The pain usually peaks in the late afternoon or early evening and can also be evident in the early morning upon awakening from sleep. The pain can be divided into two types.

Dull, aching, throbbing pain that becomes more constant over time and is predictable. It can also be accompanied by stiffness after prolonged immobilization (also known as "gelling phenomenon").

Intense, unpredictable pain for short periods can be emotionally traumatizing and limit the patient's readiness to participate in daily activities.

Based on the aforementioned types of pain, OA can be clinically classified into three stages:

1. Early OA: Predictable sharp pain that is often triggered by a mechanical stimulus that limits the patient's ability to participate in high impact activities.

2. Mid OA: In addition to the pain described above, there is unpredictable joint pain or locking - particularly for the knee. The pain becomes increasingly more constant and can affect daily activities.

3. Advanced OA: Constant dull-aching pain with intermittent short episodes of unpredictable intense pain that results in avoidance of engaging in recreational or social activities.

Additional joint symptoms include tenderness, stiffness, crepitus, limited range of movement, joint swelling, deformity, or instability.

Findings on physical examination in OA include bony enlargement (most commonly affecting the DIP and PIP joints of the fingers and toes), crepitus, effusions (non-inflammatory), joint line tenderness, and limited range of motion due to pain, swelling, or joint deformity. Heberden's nodes describe the posterolateral bony swelling of the DIP joints, and Bouchard nodes describe the posterolateral bony swelling of the PIP joints. OA involving the base of the thumb (first CMC joint) is often described as a "shoulder appearance" or "squaring".[9][10][11]

Evaluation

No laboratory test can diagnose osteoarthritis, as the diagnosis is clinically based. Imaging can aid in the diagnosis of OA and can be used to exclude other types of arthritis. Inflammatory markers, including the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), are usually normal in OA but may be useful in ruling out other conditions when the diagnosis is uncertain. Additional laboratory testing can be employed to exclude inflammatory conditions such as rheumatoid arthritis, which may include a rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies. Genetic testing looking into aberrations in collagen formation and other collagen matrix proteins, which lead to premature OA, are currently employed by research facilities. Many other biomarkers are being investigated as novel techniques to diagnose early OA, monitor disease progression, and/or respond to interventions. More data is needed, however, to validate these methods.

A variety of imaging modalities are available to confirm the diagnosis and evaluate the severity of the OA. The most commonly used modality in clinical practice is plain radiography. The European League Against Rheumatism (EULAR) recommends plain radiography as the gold standard for the initial assessment of knee or hand OA. Findings consistent with OA in plain radiography include joint space narrowing, subchondral sclerosis, subchondral cysts, and osteophyte formation. Subchondral erosions and ankylosis can be seen in radiographic films of erosive hand OA. MRI may be helpful in patients with an uncertain diagnosis to evaluate surrounding joint structures. Ultrasound is an accessible and fast imaging modality that can be used to assess inflammatory changes, including osteophytes and joint effusions, with more specificity to the peripheral joints.[12][13][14][15]

Treatment / Management

Management Overview

Management of osteoarthritis is based on the severity and distribution of the disease. Non-medical interventions, including physical therapy and weight loss, are strongly effective and should be initially attempted. Bracing, splinting, using a cane, and other assistive devices are additional non-medical treatments that should be considered when appropriate. Oral or topical NSAIDs are first-line therapies if pharmacological options are being considered. Oral NSAIDs should be avoided in patients who have a history of coronary artery disease or stroke. They should also be limited in patients with an increased risk of developing gastrointestinal complications, including those with a history of peptic ulcer disease, the elderly, or those using corticosteroids. Intra-articular corticosteroid injections should be used sparingly as well. Repeated injections have been shown to accelerate joint damage. SNRIs (Duloxetine), muscle relaxants, glucosamine and chondroitin sulfate, visco-supplementation injections, and opioids are other measures available as treatment options for OA. Various treatment interventions were evaluated and found to be ineffective in pain relief, including acetaminophen and topical capsaicin. There are relatively new treatments that have not yet been proven effective, including platelet-rich plasma, stem cell treatments, and cannabinoids. Tricyclic antidepressants have also been tried to help control pain. Significant advances in evaluating the biochemistry of cartilage, nerve transmission, and inflammatory cytokines are also pointing to newer treatments. Further research is needed to evaluate the efficacy and safety of these agents.[16][17][18][19]

Primary Knee and Hip Osteoarthritis

The initial management of primary knee and hip osteoarthritis follows the general guidelines outlined above. Weight loss should be attempted in any patient with BMI is greater than 25kg/m2. At any point in the disease, a trial of exercise focusing on muscle strengthening and improving range of motion using low impact modalities should be attempted. These exercises can be either land-based or aquatic. Adjunctive measures can also include ice or heat, therapeutic ultrasound, electrical stimulation (such as transcutaneous electrical nerve stimulation [TENS], or neuromuscular electrical stimulation [NMES]).

Although not completely understood, glucosamine and chondroitin sulfate supplementation can help reduce the pain in patients with knee OA. No significant reduction in pain or function was reported with the use of vitamin D supplementation.[20]

If a pharmacological option is being considered, the lowest effective dose of NSAIDs should be used. Topical diclofenac was found to be superior to oral NSAIDs in reducing pain in clinical trials. Acetaminophen was found to lack significant pain reduction in knee osteoarthritis, presumed to be due to the lack of anti-inflammatory effects. Tramadol is a weak opioid and is another pharmacological option. Tramadol alone or combined with acetaminophen has limited benefit in relieving chronic pain in OA compared to placebo.[21][22][23]

Intra-articular corticosteroid injections can also be considered in moderate to severe pain despite the use of oral analgesics. It can provide immediate pain relief that can last for 12-week. Long term efficacy has not been proven, and frequent injections should be avoided due to the possible risk of promoting further cartilage damage.[23][24][25]

Intra-articular hyaluronic acid injections have conflicting and limited evidence demonstrating small benefits in reducing pain and improving knee OA function. These injections remain a treatment option, however, with rare side effects.[25] Compared to platelet-rich plasma (PRP) injections, treatment with PRP was found to be superior to intraarticular hyaluronic acid injections. It can reduce pain and improve function in patients with knee OA without an increased risk of adverse events.[26][27][28]

Partial or total knee replacement is reserved for patients who fail both pharmacological and non-pharmacological treatment modalities. Less invasive joint-preserving surgical interventions such as joint resurfacing, unicompartmental knee arthroplasty, or hip osteotomy should be considered in younger patients with the limited disease who remain symptomatic despite conservative management. Arthroscopic debridement was found to be ineffective and can accelerate OA.[29]

Primary Hand Osteoarthritis

Non-pharmacological treatment options in primary hand osteoarthritis include the local application of heat or cold, splinting, physical and occupational therapy to improve range of motion and muscle strength. Topical or oral NSAIDs are first-line pharmacological therapy in hand OA. Intraarticular corticosteroid injections are not recommended but are occasionally used for flares. Surgery is often reserved for severe erosive disease with loss of function and persistent pain.[30][31][32]

Differential Diagnosis

Prognosis

Clinically symptomatic osteoarthritis progresses slowly over time but can accelerate with trauma or overuse. Radiographic progression is also usually slowly progressive. High-quality data are lacking to support which findings indicate a poor prognostic value. It is generally understood that certain presentations are linked with a less favorable prognosis, including severe pain, muscle weakness, high BMI, worsening radiographic findings, depression, and widespread disease. A high BMI and intensive physical activity at work predict knee replacement surgery in the future.[33]

Complications

Deterrence and Patient Education

Patients with osteoarthritis or who are at risk for developing osteoarthritis should be educated on lifestyle modifications to reduce the risk of disease progression or development. Patient education should focus on weight loss and moderate daily exercise to improve mobility and stability. Patients should be advised to avoid overuse of pain medication and watch for unfavorable side effects from their medication's prolonged use. Available assistive devices, including canes and splints, should be offered to patients if clinically indicated.

Enhancing Healthcare Team Outcomes

Many patients with osteoarthritis suffer from chronic pain and difficulty performing daily activities; hence, an interprofessional approach is necessary to improve this large cohort of patients' quality of life. Primary care physicians (internists or family physicians), orthopedic surgeons, rheumatologists, specialty trained nurses, and physical therapists share the responsibility to the care of these patients. Most importantly, patients should be counseled and educated about the prognosis and natural history of the disease. Patients should be encouraged to implement lifestyle modifications and control modifiable risk factors to hinder the disease's progression. Referring patients to physiotherapy, orthotics, occupational therapy, or dietitian services is recommended if clinically indicated.[34][35] [Level 5]

Referral to the orthopedic surgeon should not be delayed in patients who fail to respond adequately to pharmacological management. Joint replacement surgeries have high success rates and can effectively alleviate pain and improve joint alignment lasting 10 to 15 years.[36][37] [Level 5]

References

Disclosure: Samar Aboulenain declares no relevant financial relationships with ineligible companies.

Disclosure: Ahmed Saber declares no relevant financial relationships with ineligible companies.

# data[].attributes.attachment_link.description
Osteoarthritis (OA) is the most common type of arthritis in clinical practice and is one of the leading causes of disability worldwide. The presence of radiographic evidence of OA occurs in most people by age 65 and is found in about 80% of those over age 75.